Antibody data
- Antibody Data
- Antigen structure
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- Comments [0]
- Validations [0]
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- Product number
- FNab09446 - Provider product page
- Provider
- FineTest Biotech
- Product name
- VPS4B antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant protein fragment
- Description
- Involved in late steps of the endosomal multivesicular bodies(MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding(HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan(PubMed:22660413).
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Antigen sequence
vacuolar protein sorting 4 homolog
B- Epitope
- IgG
- Isotype
- IgG
- Vial size
- 100¦Ìg
- Concentration
- Immunogen affinity purified
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
- Handling
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
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