CABT-RM121

antibody from Creative Diagnostics

Targeting: MSLN CAK1, MPF

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-RM121

Provider

Creative Diagnostics

Product name

Mouse Anti-MSLN monoclonal antibody, clone NO-2

Antibody type

Monoclonal

Description

Mesothelin is encoded by the MSLN gene in human. Mesothelin is a glycophosphatidylinositol (GPI)-linked cell surface protein that normally expressed in lung and at lower levels in heart, placenta, and kidney. It is highly expressed in several types of malignant tumors and is associated with increased tumor aggressiveness and poor clinical outcome. Antibodies against mesothelin have been detected in patients with mesothelioma and ovarian cancer. Mesothelin plays a role in cellular adhesion. Mesothelin is synthesized with a signal peptide (aa 1-36) and a propeptide (aa 607-630) that are cleaved to produce mature mesothelin, which can be cleaved further by furin-like convertase to generate megakaryocyte-potentiating factor (aa 37-206) and the cleaved form of mesothelin (aa 296-606). Four isoforms of mesothelin have been described that are produced by alternative splicing.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG