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- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- ABIN499215 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-FYN-Binding Protein (FYB) (C-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- A 20 amino acid peptide from near the carboxy terminus of Human ADAP (AP30019CP-N)
- Description
- Affinity chromatography purified via peptide column
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- C-Term
- Isotype
- IgG
- Vial size
- 0.1 mg
- Storage
- Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Adhesion and degranulation-promoting adapter protein (ADAP) positively regulates T cell sensitivity to antigen and T cell survival.
Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1.
The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes.
Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap.
Mueller KL, Thomas MS, Burbach BJ, Peterson EJ, Shimizu Y
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3559-69
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3559-69
Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1.
Medeiros RB, Burbach BJ, Mueller KL, Srivastava R, Moon JJ, Highfill S, Peterson EJ, Shimizu Y
Science (New York, N.Y.) 2007 May 4;316(5825):754-8
Science (New York, N.Y.) 2007 May 4;316(5825):754-8
The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes.
Rawlings DJ, Sommer K, Moreno-García ME
Nature reviews. Immunology 2006 Nov;6(11):799-812
Nature reviews. Immunology 2006 Nov;6(11):799-812
Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap.
Griffiths EK, Krawczyk C, Kong YY, Raab M, Hyduk SJ, Bouchard D, Chan VS, Kozieradzki I, Oliveira-Dos-Santos AJ, Wakeham A, Ohashi PS, Cybulsky MI, Rudd CE, Penninger JM
Science (New York, N.Y.) 2001 Sep 21;293(5538):2260-3
Science (New York, N.Y.) 2001 Sep 21;293(5538):2260-3
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Western blot analysis of ADAP in K562 cell lysate with AP30019PU-N ADAP antibody at (A) 0.5 and (B) 1 ?g/ml.
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Immunocytochemistry of ADAP in K562 cells with AP30019PU-N ADAP antibody at 10 ?g/ml.
