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- References [16]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- NB100-56646 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-56646, RRID:AB_838219
- Product name
- Rabbit Polyclonal TTC11 Antibody
- Antibody type
- Polyclonal
- Description
- Unpurified.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.2 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Liraglutide Protects Against Brain Amyloid-β(1-42) Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation.
Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells.
Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice.
Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model.
Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria.
The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease.
Impaired mitochondrial dynamics and bioenergetics in diabetic skeletal muscle.
Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes.
Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats.
Nitric oxide regulates vascular adaptive mitochondrial dynamics.
LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1.
Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness.
Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice.
Impaired balance of mitochondrial fission and fusion in Alzheimer's disease.
Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins.
Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology.
Duarte AI, Candeias E, Alves IN, Mena D, Silva DF, Machado NJ, Campos EJ, Santos MS, Oliveira CR, Moreira PI
International journal of molecular sciences 2020 Mar 4;21(5)
International journal of molecular sciences 2020 Mar 4;21(5)
Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells.
Plácido AI, Pereira CMF, Correira SC, Carvalho C, Oliveira CR, Moreira PI
Molecular neurobiology 2017 Jan;54(1):154-168
Molecular neurobiology 2017 Jan;54(1):154-168
Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice.
Brown JL, Rosa-Caldwell ME, Lee DE, Blackwell TA, Brown LA, Perry RA, Haynie WS, Hardee JP, Carson JA, Wiggs MP, Washington TA, Greene NP
Journal of cachexia, sarcopenia and muscle 2017 Dec;8(6):926-938
Journal of cachexia, sarcopenia and muscle 2017 Dec;8(6):926-938
Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model.
Keller AC, Knaub LA, McClatchey PM, Connon CA, Bouchard R, Miller MW, Geary KE, Walker LA, Klemm DJ, Reusch JE
Oxidative medicine and cellular longevity 2016;2016:8524267
Oxidative medicine and cellular longevity 2016;2016:8524267
Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria.
El-Sikhry HE, Alsaleh N, Dakarapu R, Falck JR, Seubert JM
PloS one 2016;11(8):e0160380
PloS one 2016;11(8):e0160380
The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease.
Santos D, Esteves AR, Silva DF, Januário C, Cardoso SM
Molecular neurobiology 2015 Aug;52(1):573-86
Molecular neurobiology 2015 Aug;52(1):573-86
Impaired mitochondrial dynamics and bioenergetics in diabetic skeletal muscle.
Liu R, Jin P, Yu L, Wang Y, Han L, Shi T, Li X
PloS one 2014;9(3):e92810
PloS one 2014;9(3):e92810
Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes.
Santos RX, Correia SC, Alves MG, Oliveira PF, Cardoso S, Carvalho C, Seiça R, Santos MS, Moreira PI
Molecular and cellular biochemistry 2014 Sep;394(1-2):13-22
Molecular and cellular biochemistry 2014 Sep;394(1-2):13-22
Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats.
Santos RX, Correia SC, Alves MG, Oliveira PF, Cardoso S, Carvalho C, Duarte AI, Santos MS, Moreira PI
Biochimica et biophysica acta 2014 Jul;1842(7):1154-66
Biochimica et biophysica acta 2014 Jul;1842(7):1154-66
Nitric oxide regulates vascular adaptive mitochondrial dynamics.
Miller MW, Knaub LA, Olivera-Fragoso LF, Keller AC, Balasubramaniam V, Watson PA, Reusch JE
American journal of physiology. Heart and circulatory physiology 2013 Jun 15;304(12):H1624-33
American journal of physiology. Heart and circulatory physiology 2013 Jun 15;304(12):H1624-33
LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1.
Wang X, Yan MH, Fujioka H, Liu J, Wilson-Delfosse A, Chen SG, Perry G, Casadesus G, Zhu X
Human molecular genetics 2012 May 1;21(9):1931-44
Human molecular genetics 2012 May 1;21(9):1931-44
Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness.
Wortmann SB, Vaz FM, Gardeitchik T, Vissers LE, Renkema GH, Schuurs-Hoeijmakers JH, Kulik W, Lammens M, Christin C, Kluijtmans LA, Rodenburg RJ, Nijtmans LG, Grünewald A, Klein C, Gerhold JM, Kozicz T, van Hasselt PM, Harakalova M, Kloosterman W, Barić I, Pronicka E, Ucar SK, Naess K, Singhal KK, Krumina Z, Gilissen C, van Bokhoven H, Veltman JA, Smeitink JA, Lefeber DJ, Spelbrink JN, Wevers RA, Morava E, de Brouwer AP
Nature genetics 2012 Jun 10;44(7):797-802
Nature genetics 2012 Jun 10;44(7):797-802
Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice.
Xu YF, Gendron TF, Zhang YJ, Lin WL, D'Alton S, Sheng H, Casey MC, Tong J, Knight J, Yu X, Rademakers R, Boylan K, Hutton M, McGowan E, Dickson DW, Lewis J, Petrucelli L
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Aug 11;30(32):10851-9
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Aug 11;30(32):10851-9
Impaired balance of mitochondrial fission and fusion in Alzheimer's disease.
Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, Zhu X
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Jul 15;29(28):9090-103
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Jul 15;29(28):9090-103
Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins.
Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X
Proceedings of the National Academy of Sciences of the United States of America 2008 Dec 9;105(49):19318-23
Proceedings of the National Academy of Sciences of the United States of America 2008 Dec 9;105(49):19318-23
Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology.
Duvezin-Caubet S, Jagasia R, Wagener J, Hofmann S, Trifunovic A, Hansson A, Chomyn A, Bauer MF, Attardi G, Larsson NG, Neupert W, Reichert AS
The Journal of biological chemistry 2006 Dec 8;281(49):37972-9
The Journal of biological chemistry 2006 Dec 8;281(49):37972-9
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: TTC11 Antibody [NB100-56646] - Analysis of Fis1 in A) human HeLa and B) mouse NIH 3T3 lysate using Fis1 antibody at 1:1000 dilution. B. Specificity validation of the Fis1 antibody. Fis1 was analyzed in M17 cells stably transfected with vector only, Fis1 RNAi, Fis1 (Fis1wt OE) or left untransfected (negative control). The western blot data showed that M17 cells expressed Fis1 (Vector, Untransfected control) which could be knocked down by Fis1 RNAi. Cells transfected with Fis1 overexpressed Fis1. M17 is a human neuroblastoma cell line.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: TTC11 Antibody [NB100-56646] - Analysis of methcarn-fixed, paraffin-embedded hippocampus from control (normal) and Alzheimer brain. Quantification in five AD brains and five age-matched controls indicated that Fis1 was detected in only the soma in ~80% of pyramidal neurons in AD hippocampus, significantly different from what was seen for control hippocampal neurons. Source: Wang et al, 2009.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: TTC11 Antibody [NB100-56646] - Staining of human liver tissue at 1:100.
