BS7650

antibody from Bioworld Technology, Inc
Targeting: ENG CD105, END, HHT1, ORW, ORW1
Provider product page for BS7650
Western blot
Immunohistochemistry

Antibody data

Product number
BS7650 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Endoglin polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human Endoglin.
Description
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized by vascular abnormalities such as dilated vessels, hemorrhages, liver and lung congestion, and brain or heart ischemia. Mutations in two genes, Endoglin (also designated CD105) and ALK-1 (Activin receptorlike kinase 1, also designated TGFÉÇ superfamily RI), are responsible for HHT. Endoglin is mutated in HHT1, and ALK-1 is mutated in HHT2, both of which are thought to be caused by haploinsufficiency. Endoglin and ALK-1 are type III and type I members of the TGFÉÇ receptor superfamily, respectively, that are expressed on vascular endothelial cells. Endoglin can only bind ligands of the TGFÉÇ superfamily via association with the respective ligand binding receptors for TGFÉÇ1, TGFÉÇ3, Activin-A, BMP-2 and BMP-7. The human ALK-1 gene encodes two protein species which exist as a result of either glycosylation or alternative splicing events. ALK-1 preferentially binds TGFÉÇ1 and is expressed in bone marrow stromal cells, lung, brain, kidney and spleen.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ENG protein structure - BS7650 shown in red.