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- Antibody Data
- Antigen structure
- References [3]
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- Western blot [1]
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- Product number
- MAB1718 - Provider product page
- Provider
- R&D Systems
- Product name
- Human CLEC-2/CLEC1B Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human CLEC-2/CLEC1B in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human CLEC-1 is observed.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
AAF36777- Isotype
- IgG
- Antibody clone number
- 219150
- Vial size
- 500 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Microenvironment inflammatory infiltrate drives growth speed and outcome of hepatocellular carcinoma: a prospective clinical study.
Inhibitory effects of polypeptides derived from a snake venom C-type lectin, aggretin, on tumor cell-induced platelet aggregation.
A novel mechanism of cytokine release in phagocytes induced by aggretin, a snake venom C-type lectin protein, through CLEC-2 ligation.
Critelli R, Milosa F, Faillaci F, Condello R, Turola E, Marzi L, Lei B, Dituri F, Andreani S, Sighinolfi P, Manni P, Maiorana A, Caporali C, di Benedetto F, Del Buono M, De Maria N, Schepis F, Martinez-Chantar ML, Giannelli G, Villa E
Cell death & disease 2017 Aug 24;8(8):e3017
Cell death & disease 2017 Aug 24;8(8):e3017
Inhibitory effects of polypeptides derived from a snake venom C-type lectin, aggretin, on tumor cell-induced platelet aggregation.
Chang CH, Chung CH, Hsu CC, Peng HC, Huang TF
Journal of thrombosis and haemostasis : JTH 2014 Apr;12(4):540-9
Journal of thrombosis and haemostasis : JTH 2014 Apr;12(4):540-9
A novel mechanism of cytokine release in phagocytes induced by aggretin, a snake venom C-type lectin protein, through CLEC-2 ligation.
Chang CH, Chung CH, Hsu CC, Huang TY, Huang TF
Journal of thrombosis and haemostasis : JTH 2010 Nov;8(11):2563-70
Journal of thrombosis and haemostasis : JTH 2010 Nov;8(11):2563-70
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Supportive validation
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- R&D Systems (provider)
- Main image
- Experimental details
- Detection of Human CLEC-2/CLEC1B by Western Blot. Western blot shows lysates of human platelets. PVDF Membrane was probed with 2 µg/mL of Mouse Anti-Human CLEC-2/CLEC1B Monoclonal Antibody (Catalog # MAB1718) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for CLEC-2/CLEC1B at approximately 35 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 5.
