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- Antigen structure
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- Product number
- AF1756 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse Dectin-1/CLEC7A Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse Dectin-1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human Dectin-1 and recombinant mouse Dectin-2 alpha is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
Q6QLQ4- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.
The dectin 1 agonist curdlan regulates osteoclastogenesis by inhibiting nuclear factor of activated T cells cytoplasmic 1 (NFATc1) through Syk kinase.
Histoplasma capsulatum alpha-(1,3)-glucan blocks innate immune recognition by the beta-glucan receptor.
The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade.
Götzl JK, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, Colombo AV, Deussing M, Wagner M, Winkelmann J, Diehl-Schmid J, Levin J, Fellerer K, Reifschneider A, Bultmann S, Bartenstein P, Rominger A, Tahirovic S, Smith ST, Madore C, Butovsky O, Capell A, Haass C
EMBO molecular medicine 2019 Jun;11(6)
EMBO molecular medicine 2019 Jun;11(6)
The dectin 1 agonist curdlan regulates osteoclastogenesis by inhibiting nuclear factor of activated T cells cytoplasmic 1 (NFATc1) through Syk kinase.
Yamasaki T, Ariyoshi W, Okinaga T, Adachi Y, Hosokawa R, Mochizuki S, Sakurai K, Nishihara T
The Journal of biological chemistry 2014 Jul 4;289(27):19191-203
The Journal of biological chemistry 2014 Jul 4;289(27):19191-203
Histoplasma capsulatum alpha-(1,3)-glucan blocks innate immune recognition by the beta-glucan receptor.
Rappleye CA, Eissenberg LG, Goldman WE
Proceedings of the National Academy of Sciences of the United States of America 2007 Jan 23;104(4):1366-70
Proceedings of the National Academy of Sciences of the United States of America 2007 Jan 23;104(4):1366-70
The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade.
Fuller GL, Williams JA, Tomlinson MG, Eble JA, Hanna SL, Pöhlmann S, Suzuki-Inoue K, Ozaki Y, Watson SP, Pearce AC
The Journal of biological chemistry 2007 Apr 27;282(17):12397-409
The Journal of biological chemistry 2007 Apr 27;282(17):12397-409
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