12024-1-AP
antibody from Proteintech Group
Targeting: NUSAP1
ANKT, BM037, FLJ13421, LNP, PRO0310p1, Q0310, SAPL
Antibody data
- Antibody Data
- Antigen structure
- References [26]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 12024-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12024-1-AP, RRID:AB_2157789
- Product name
- NUSAP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NUSAP1 antibody (Cat. #12024-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Nucleolar and spindle‑associated protein 1 promotes non‑small cell lung cancer progression and serves as an effector of myocyte enhancer factor 2D.
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Nucleolar and Spindle Associated Protein 1 (NUSAP1) Promotes Bladder Cancer Progression Through the TGF-β Signaling Pathway.
NUSAP1 Promotes Gastric Cancer Tumorigenesis and Progression by Stabilizing the YAP1 Protein.
RepoMan stimulates the chromosome-dependent pathway of microtubule assembly.
Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.
Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine.
Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non-small cell lung cancer.
Hepatitis B virus X protein enhances hepatocarcinogenesis by depressing the targeting of NUSAP1 mRNA by miR-18b.
Nucleolar spindle-associated protein 1 promotes tumorigenesis and predicts poor prognosis in human esophageal squamous cell carcinoma.
Downregulation of nucleolar and spindle-associated protein 1 expression suppresses liver cancer cell function.
Nucleolar and spindle-associated protein 1 is a tumor grade correlated prognosis marker for glioma patients.
High NUSAP1 expression predicts poor prognosis in colon cancer.
microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis.
NUSAP1 promotes invasion and metastasis of prostate cancer.
APLP2, RRM2, and PRC1: New Putative Markers for the Differential Diagnosis of Thyroid Follicular Lesions.
Targeting PI3K/mTOR signaling exerts potent antitumor activity in pheochromocytoma in vivo.
Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma.
High Levels of Nucleolar Spindle-Associated Protein and Reduced Levels of BRCA1 Expression Predict Poor Prognosis in Triple-Negative Breast Cancer.
The selective inhibition of protein phosphatase-1 results in mitotic catastrophe and impaired tumor growth.
NUSAP1 expression is upregulated by loss of RB1 in prostate cancer cells.
Enhanced protein degradation by branched ubiquitin chains.
Microtubule-dependent regulation of mitotic protein degradation.
Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas.
Increased expression of NuSAP in recurrent prostate cancer is mediated by E2F1.
Regulated degradation of spindle assembly factors by the anaphase-promoting complex.
Ling B, Wei P, Xiao J, Cen B, Wei H, Feng X, Ye G, Li S, Zhang Z, Liang W, Huang S, Huang W
Oncology reports 2021 Mar;45(3):1044-1058
Oncology reports 2021 Mar;45(3):1044-1058
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Zhang Z, Wu H, Huang S, Chen L, Chen X, Zhang W, Liao L, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
Nucleolar and Spindle Associated Protein 1 (NUSAP1) Promotes Bladder Cancer Progression Through the TGF-β Signaling Pathway.
Gao S, Yin H, Tong H, Zhan K, Yang G, Hossain MA, Li T, Gou X, He W
OncoTargets and therapy 2020;13:813-825
OncoTargets and therapy 2020;13:813-825
NUSAP1 Promotes Gastric Cancer Tumorigenesis and Progression by Stabilizing the YAP1 Protein.
Guo H, Zou J, Zhou L, Zhong M, He Y, Huang S, Chen J, Li J, Xiong J, Fang Z, Xiang X
Frontiers in oncology 2020;10:591698
Frontiers in oncology 2020;10:591698
RepoMan stimulates the chromosome-dependent pathway of microtubule assembly.
De Munter S, Van der Hoeven G, Bollen M
Cell cycle (Georgetown, Tex.) 2020 Nov;19(22):3029-3041
Cell cycle (Georgetown, Tex.) 2020 Nov;19(22):3029-3041
Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.
Wang L, Muneer A, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Gheorghe C, Torralba K, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
bioRxiv : the preprint server for biology 2020 Nov 16;
bioRxiv : the preprint server for biology 2020 Nov 16;
Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine.
Wang Y, Song W, Wang J, Wang T, Xiong X, Qi Z, Fu W, Yang X, Chen YG
The Journal of experimental medicine 2020 Feb 3;217(2)
The Journal of experimental medicine 2020 Feb 3;217(2)
Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non-small cell lung cancer.
Li X, Fu Y, Xia X, Zhang X, Xiao K, Zhuang X, Zhang Y
Cancer medicine 2019 Sep;8(12):5750-5759
Cancer medicine 2019 Sep;8(12):5750-5759
Hepatitis B virus X protein enhances hepatocarcinogenesis by depressing the targeting of NUSAP1 mRNA by miR-18b.
Yang Z, Li J, Feng G, Wang Y, Yang G, Liu Y, Zhang S, Feng J, Zhang X
Cancer biology & medicine 2019 May;16(2):276-287
Cancer biology & medicine 2019 May;16(2):276-287
Nucleolar spindle-associated protein 1 promotes tumorigenesis and predicts poor prognosis in human esophageal squamous cell carcinoma.
Guan C, Liu Z, Lu C, Xiao M, Shi H, Ni R, Bian Z
Journal of cellular biochemistry 2019 Feb 21;
Journal of cellular biochemistry 2019 Feb 21;
Downregulation of nucleolar and spindle-associated protein 1 expression suppresses liver cancer cell function.
Wang Y, Ju L, Xiao F, Liu H, Luo X, Chen L, Lu Z, Bian Z
Experimental and therapeutic medicine 2019 Apr;17(4):2969-2978
Experimental and therapeutic medicine 2019 Apr;17(4):2969-2978
Nucleolar and spindle-associated protein 1 is a tumor grade correlated prognosis marker for glioma patients.
Zhu T, Xie P, Gao YF, Huang MS, Li X, Zhang W, Zhou HH, Liu ZQ
CNS neuroscience & therapeutics 2018 Mar;24(3):178-186
CNS neuroscience & therapeutics 2018 Mar;24(3):178-186
High NUSAP1 expression predicts poor prognosis in colon cancer.
Liu Z, Guan C, Lu C, Liu Y, Ni R, Xiao M, Bian Z
Pathology, research and practice 2018 Jul;214(7):968-973
Pathology, research and practice 2018 Jul;214(7):968-973
microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis.
Roy S, Hooiveld GJ, Seehawer M, Caruso S, Heinzmann F, Schneider AT, Frank AK, Cardenas DV, Sonntag R, Luedde M, Trautwein C, Stein I, Pikarsky E, Loosen S, Tacke F, Ringelhan M, Avsaroglu SK, Goga A, Buendia MA, Vucur M, Heikenwalder M, Zucman-Rossi J, Zender L, Roderburg C, Luedde T
Gastroenterology 2018 Dec;155(6):1951-1966.e26
Gastroenterology 2018 Dec;155(6):1951-1966.e26
NUSAP1 promotes invasion and metastasis of prostate cancer.
Gordon CA, Gong X, Ganesh D, Brooks JD
Oncotarget 2017 May 2;8(18):29935-29950
Oncotarget 2017 May 2;8(18):29935-29950
APLP2, RRM2, and PRC1: New Putative Markers for the Differential Diagnosis of Thyroid Follicular Lesions.
Castelblanco E, Zafon C, Maravall J, Gallel P, Martinez M, Capel I, Bella MR, Halperin I, Temprana J, Iglesias C, Puig-Domingo M, Robledo M, Matias-Guiu X, Mauricio D
Thyroid : official journal of the American Thyroid Association 2017 Jan;27(1):59-66
Thyroid : official journal of the American Thyroid Association 2017 Jan;27(1):59-66
Targeting PI3K/mTOR signaling exerts potent antitumor activity in pheochromocytoma in vivo.
Lee M, Minaskan N, Wiedemann T, Irmler M, Beckers J, Yousefi BH, Kaissis G, Braren R, Laitinen I, Pellegata NS
Endocrine-related cancer 2017 Jan;24(1):1-15
Endocrine-related cancer 2017 Jan;24(1):1-15
Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma.
Okamoto A, Higo M, Shiiba M, Nakashima D, Koyama T, Miyamoto I, Kasama H, Kasamatsu A, Ogawara K, Yokoe H, Tanzawa H, Uzawa K
PloS one 2015;10(11):e0142252
PloS one 2015;10(11):e0142252
High Levels of Nucleolar Spindle-Associated Protein and Reduced Levels of BRCA1 Expression Predict Poor Prognosis in Triple-Negative Breast Cancer.
Chen L, Yang L, Qiao F, Hu X, Li S, Yao L, Yang XL, Shao ZM
PloS one 2015;10(10):e0140572
PloS one 2015;10(10):e0140572
The selective inhibition of protein phosphatase-1 results in mitotic catastrophe and impaired tumor growth.
Winkler C, De Munter S, Van Dessel N, Lesage B, Heroes E, Boens S, Beullens M, Van Eynde A, Bollen M
Journal of cell science 2015 Dec 15;128(24):4526-37
Journal of cell science 2015 Dec 15;128(24):4526-37
NUSAP1 expression is upregulated by loss of RB1 in prostate cancer cells.
Gordon CA, Gulzar ZG, Brooks JD
The Prostate 2015 Apr 1;75(5):517-26
The Prostate 2015 Apr 1;75(5):517-26
Enhanced protein degradation by branched ubiquitin chains.
Meyer HJ, Rape M
Cell 2014 May 8;157(4):910-21
Cell 2014 May 8;157(4):910-21
Microtubule-dependent regulation of mitotic protein degradation.
Song L, Craney A, Rape M
Molecular cell 2014 Jan 23;53(2):179-92
Molecular cell 2014 Jan 23;53(2):179-92
Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas.
Lee M, Marinoni I, Irmler M, Psaras T, Honegger JB, Beschorner R, Anastasov N, Beckers J, Theodoropoulou M, Roncaroli F, Pellegata NS
Acta neuropathologica 2013 Jul;126(1):137-50
Acta neuropathologica 2013 Jul;126(1):137-50
Increased expression of NuSAP in recurrent prostate cancer is mediated by E2F1.
Gulzar ZG, McKenney JK, Brooks JD
Oncogene 2013 Jan 3;32(1):70-7
Oncogene 2013 Jan 3;32(1):70-7
Regulated degradation of spindle assembly factors by the anaphase-promoting complex.
Song L, Rape M
Molecular cell 2010 May 14;38(3):369-82
Molecular cell 2010 May 14;38(3):369-82
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- rat colon tissue were subjected to SDS PAGE followed by western blot with 12024-1-AP( NUSAP1 Antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using NUSAP1 antibody 12024-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 12024-1-AP(NUSAP1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue