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antibody from Invitrogen Antibodies
Targeting: KLRK1
CD314, D12S2489E, KLR, NKG2-D, NKG2D
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Flow cytometry [1]
- Other assay [1]
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- Product number
- 11-5878-41 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD314 (NKG2D) Monoclonal Antibody (1D11), FITC, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- This antibody is specific to PRDX4.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Green dye
- Isotype
- IgG
- Antibody clone number
- 1D11
- Vial size
- 25 Tests
- Concentration
- 5 µL/Test
- Storage
- 4° C, store in dark, DO NOT FREEZE!
Submitted references NKG2D as a Cell Surface Marker on γδ-T Cells for Predicting Pregnancy Outcomes in Patients With Unexplained Repeated Implantation Failure.
The number and cytotoxicity and the expression of cytotoxicity-related molecules in peripheral natural killer (NK) cells do not predict the repeated implantation failure (RIF) for the in vitro fertilization patients.
miR-20a regulates sensitivity of colorectal cancer cells to NK cells by targeting MICA.
Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape.
Natural killer cells inhibit pulmonary metastasis of hepatocellular carcinoma in nude mice.
Resveratrol sensitized leukemia stem cell-like KG-1a cells to cytokine-induced killer cells-mediated cytolysis through NKG2D ligands and TRAIL receptors.
Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis.
NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment.
Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.
Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells.
Huang C, Xiang Z, Zhang Y, Li Y, Xu J, Zhang H, Zeng Y, Tu W
Frontiers in immunology 2021;12:631077
Frontiers in immunology 2021;12:631077
The number and cytotoxicity and the expression of cytotoxicity-related molecules in peripheral natural killer (NK) cells do not predict the repeated implantation failure (RIF) for the in vitro fertilization patients.
Zhang H, Huang C, Chen X, Li L, Liu S, Li Y, Zhang Y, Zeng Y, Hu L
Genes & diseases 2020 Jun;7(2):283-289
Genes & diseases 2020 Jun;7(2):283-289
miR-20a regulates sensitivity of colorectal cancer cells to NK cells by targeting MICA.
Tang S, Fu H, Xu Q, Zhou Y
Bioscience reports 2019 Jul 31;39(7)
Bioscience reports 2019 Jul 31;39(7)
Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape.
Zhao H, Jia H, Han Q, Zhang J
Oncology reports 2018 Sep;40(3):1657-1665
Oncology reports 2018 Sep;40(3):1657-1665
Natural killer cells inhibit pulmonary metastasis of hepatocellular carcinoma in nude mice.
Hong ZF, Zhao WX, Yin ZY, Xie CR, Xu YP, Chi XQ, Zhang S, Wang XM
Oncology letters 2016 Mar;11(3):2019-2026
Oncology letters 2016 Mar;11(3):2019-2026
Resveratrol sensitized leukemia stem cell-like KG-1a cells to cytokine-induced killer cells-mediated cytolysis through NKG2D ligands and TRAIL receptors.
Hu L, Cao D, Li Y, He Y, Guo K
Cancer biology & therapy 2012 May;13(7):516-26
Cancer biology & therapy 2012 May;13(7):516-26
Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis.
Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T
Proceedings of the National Academy of Sciences of the United States of America 2003 Aug 5;100(16):9452-7
Proceedings of the National Academy of Sciences of the United States of America 2003 Aug 5;100(16):9452-7
NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment.
Roberts AI, Lee L, Schwarz E, Groh V, Spies T, Ebert EC, Jabri B
Journal of immunology (Baltimore, Md. : 1950) 2001 Nov 15;167(10):5527-30
Journal of immunology (Baltimore, Md. : 1950) 2001 Nov 15;167(10):5527-30
Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.
Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T
Science (New York, N.Y.) 1999 Jul 30;285(5428):727-9
Science (New York, N.Y.) 1999 Jul 30;285(5428):727-9
Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells.
Groh V, Steinle A, Bauer S, Spies T
Science (New York, N.Y.) 1998 Mar 13;279(5357):1737-40
Science (New York, N.Y.) 1998 Mar 13;279(5357):1737-40
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with Anti-Human CD8a eFluor® 450 (Product # 48-0086-42) and Mouse IgG1 K Isotype Control FITC (Product # 11-4714-42) (left) or Anti-Human CD314 (NKG2D) FITC (right). Cells in the lymphocyte gate were used for analysis.
- Conjugate
- Green dye
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 3 miR-20a regulates CRC cells sensitivity to NK cells depending on NKG2D signaling ( A ) Depletion of NK cells markedly abolished the cell cytotoxicity. CD56 + NK cells were depleted from PBMCs by magnetic sorting. NK cell-depleted PBMCs were then co-cultured with miR-20a overexpressing and knockdown of CRC cells at an E:T ratio of 50:1 for 16 h. ( B ) NK cells were co-cultured with miR-20a overexpressing and knockdown CRC cells at an E:T ratio of 50:1 in the presence or absence of NKG2D blocking antibody for 16 h. The specific kill of target cells were examined by FACS. All data were shown as mean +- S.E.M. from three independent experiments. * represents P
- Conjugate
- Green dye
