Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Immunohistochemistry [4]
- Flow cytometry [4]
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Validation data
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- Product number
- NB100-65956 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-65956, RRID:AB_960833
- Product name
- Mouse Monoclonal NKG2D/CD314 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A purified. NB100-65956 is specific for CD314, also known as natural killer receptor G2 (NKG2D) and as killer cell lectin-like receptor subfamily K, member 1 (KLRK1). CD314 is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. CD314 forms homodimers that signal through an associated DAP10 adaptor protein. Ligands of CD314 include MICA, MICB and UL16 binding protein (ULBP), which are inducibly expressed. Ligand binding to CD314 results in NK cell activation and potent costimulation of effector T cells. Clone 1D11 is reported to inhibit T cell recognition of MICA (1,6).
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.25 mg
- Concentration
- 1.0 mg/ml
- Storage
- Store at -20C. Avoid freeze-thaw cycles.
Submitted references Hypoxia-induced shedding of MICA and HIF1A-mediated immune escape of pancreatic cancer cells from NK cells: role of circ_0000977/miR-153 axis.
Quantitative and functional analysis of CD69+ T regulatory lymphocytes in patients with periodontal disease.
Detection and significance of cytotoxic cell subsets in biopsies of HCV-infected human livers.
Ou ZL, Luo Z, Wei W, Liang S, Gao TL, Lu YB
RNA biology 2019 Nov;16(11):1592-1603
RNA biology 2019 Nov;16(11):1592-1603
Quantitative and functional analysis of CD69+ T regulatory lymphocytes in patients with periodontal disease.
Vitales-Noyola M, Martínez-Martínez R, Loyola-Rodríguez JP, Baranda L, Niño-Moreno P, González-Amaro R
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2017 Aug;46(7):549-557
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2017 Aug;46(7):549-557
Detection and significance of cytotoxic cell subsets in biopsies of HCV-infected human livers.
Mozer-Lisewska I, Mania A, Kowala-Piaskowska A, Kluk A, Samara H, Pauli A, Żeromski J
Archivum immunologiae et therapiae experimentalis 2014 Apr;62(2):153-60
Archivum immunologiae et therapiae experimentalis 2014 Apr;62(2):153-60
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Frozen: NKG2D/CD314 Antibody (1D11) [NB100-65956] - Immunoperoxidase staining of a human spleen cryosection with Mouse anti Human CD314 antibody,
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Frozen: NKG2D/CD314 Antibody (1D11) [NB100-65956] - Immunoperoxidase staining of a human spleen cryosection with Mouse anti Human CD314 antibody,
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Frozen: NKG2D/CD314 Antibody (1D11) [NB100-65956] - Immunoperoxidase staining of a human tonsil cryosection with Mouse anti Human CD314 antibody.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Frozen: NKG2D/CD314 Antibody (1D11) [NB100-65956] - Immunoperoxidase staining of a human tonsil cryosection with Mouse anti Human CD314 antibody.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: NKG2D/CD314 Antibody (1D11) [NB100-65956] - Staining of human peripheral blood lymphocytes with MOUSE ANTI HUMAN CD314:Low Endotoxin.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: NKG2D/CD314 Antibody (1D11) [NB100-65956] - Human peripheral blood lymphocytes.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: NKG2D/CD314 Antibody (1D11) [NB100-65956] - Human peripheral blood lymphocytes.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: NKG2D/CD314 Antibody (1D11) [NB100-65956] - Analysis using the Biotin conjugate of NB100-65956. Staining of Human peripheral blood lymphocytes with biotinylated 1D11, followed by Sav-PE.