BS60676

antibody from Bioworld Technology, Inc
Targeting: CDH23 CDHR23, DFNB12, USH1D
Provider product page for BS60676

Antibody data

Product number
BS60676 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CDH23 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human CDH23
Description
Cadherin-23 represents the first in this family of calcium binding proteins of which mutations in the extracellular calcium binding domain contribute to an inherited disorder, Usher syndrome type 1D (USH1D). Patients with USH1D exhibit congenital sensorineural hearing loss, vestibular dysfunction, and visual impairment due to early onset of retinitis pigmentosa (RP). In the inner ear, cadherin-23 interacts with myosin VIIIa and harmonin to form a functional network duing hair cell differentiation, and in the retina to assemble a supra-molecular complex contributing to the organization of the cytoskeletal matrices of the pre- and post-synaptic region. A number of cadherin-23 splice variants exist in association with various phenotypic expression, indicating that differential mutations result in variable presentation of the disease.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CDH23 protein structure - BS60676 shown in red.