Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS3806 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- X11ÎÛ (R401) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 371-420 of Human X11ÎÛ.
- Description
- Amyloid ÉÇ precursor protein (ÉÇ APP) is a major constituent of the amyloid deposits in patients with Alzheimer£ªs disease. The amyloid ÉÇ precursor is known to interact with several proteins, including the G heterotrimetric protein, APP-BP1, and X11. The neuronal, transmembrane protein X11 is known to bind to the amyloid ÉÇ precurser protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular ÉÇ APP and slowing ÉÇ APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of ÉÇ APP. Multiple splice varitents of X11 have been identified, including X11 Ï«, ÉÇ and ÎÛ (also known as Mint 1, 2 and 3, respectively).
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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