13750-1-AP

antibody from Proteintech Group

Targeting: MX1 IFI-78K, lncMX1-215, MxA

Provider product page for 13750-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [65]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 13750-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13750-1-AP, RRID:AB_2266768
Product name: MX1 antibody
Antibody type: Polyclonal
Description: KD/KO validated MX1 antibody (Cat. #13750-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MX1 protein structure - 13750-1-AP shown in red.

Submitted references RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.

Abraham HG, Ulintz PJ, Goo L, Yates JA, Little AC, Bao L, Wu Z, Merajver SD
Frontiers in oncology 2021;11:712041

Human parainfluenza virus type 1 regulates cholesterol biosynthesis and establishes quiescent infection in human airway cells.

Kurebayashi Y, Bajimaya S, Watanabe M, Lim N, Lutz M, Dunagan M, Takimoto T
PLoS pathogens 2021 Sep;17(9):e1009908

Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.

Xu G, Deng F, Zuo Q, Liu L, Dou K, Cheng Z, Cao W, Luo C, Yu C, Liu S, Zhu Y
Cellular & molecular immunology 2021 Jun;18(6):1587-1589

Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20.

Stadler D, Kächele M, Jones AN, Hess J, Urban C, Schneider J, Xia Y, Oswald A, Nebioglu F, Bester R, Lasitschka F, Ringelhan M, Ko C, Chou WM, Geerlof A, van de Klundert MA, Wettengel JM, Schirmacher P, Heikenwälder M, Schreiner S, Bartenschlager R, Pichlmair A, Sattler M, Unger K, Protzer U
EMBO reports 2021 Jun 4;22(6):e49568

Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.

Cao W, Guo Y, Cheng Z, Xu G, Zuo Q, Nie L, Huang Y, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2668-2681

The Protein Kinase Receptor Modulates the Innate Immune Response against Tacaribe Virus.

Moreno H, Kunz S
Viruses 2021 Jul 7;13(7)

Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.

Zuo Q, Cheng Z, Zhang G, Xia Y, Xu G, Cao W, Yang X, Fu Y, He R, Fang P, Guo Y, Nie L, Huang Y, Liu L, Zhan J, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 15;207(2):577-589

The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells.

Kelesidis T, Madhav S, Petcherski A, Cristelle H, O'Connor E, Hultgren NW, Ritou E, Williams DS, Shirihai OS, Reddy ST
Virulence 2021 Dec;12(1):2214-2227

Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting.

Liu W, Xie L, He YH, Wu ZY, Liu LX, Bai XF, Deng DX, Xu XE, Liao LD, Lin W, Heng JH, Xu X, Peng L, Huang QF, Li CY, Zhang ZD, Wang W, Zhang GR, Gao X, Wang SH, Li CQ, Xu LY, Liu W, Li EM
Nature communications 2021 Aug 16;12(1):4961

Exosomal miR-145-5p derived from orthohantavirus-infected endothelial cells inhibits HTNV infection.

Wang X, Chen QZ, Zan YX, Wang MR, Yan J, Guo WW, Li KJ, Liu YY, Luo F, Feng Y, Hou W, Xiong HR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Oct;34(10):13809-13825

Cross-talk between SUMOylation and ISGylation in response to interferon.

El-Asmi F, McManus FP, Brantis-de-Carvalho CE, Valle-Casuso JC, Thibault P, Chelbi-Alix MK
Cytokine 2020 May;129:155025

SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation.

Li S, Li H, Zhang YL, Xin QL, Guan ZQ, Chen X, Zhang XA, Li XK, Xiao GF, Lozach PY, Cui J, Liu W, Zhang LK, Peng K
Cell reports 2020 Mar 31;30(13):4370-4385.e7

A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.

Min YQ, Ning YJ, Wang H, Deng F
The Journal of biological chemistry 2020 Jul 10;295(28):9691-9711

Direct Antiviral Activity of IFN-Stimulated Genes Is Responsible for Resistance to Paramyxoviruses in ISG15-Deficient Cells.

Holthaus D, Vasou A, Bamford CGG, Andrejeva J, Paulus C, Randall RE, McLauchlan J, Hughes DJ
Journal of immunology (Baltimore, Md. : 1950) 2020 Jul 1;205(1):261-271

The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry.

Wang G, Jiang L, Wang J, Zhang J, Kong F, Li Q, Yan Y, Huang S, Zhao Y, Liang L, Li J, Sun N, Hu Y, Shi W, Deng G, Chen P, Liu L, Zeng X, Tian G, Bu Z, Chen H, Li C
Journal of virology 2020 Jan 6;94(2)

Docosahexaenoic Acid Consumption Impedes Early Interferon- and Chemokine-Related Gene Expression While Suppressing Silica-Triggered Flaring of Murine Lupus.

Benninghoff AD, Bates MA, Chauhan PS, Wierenga KA, Gilley KN, Holian A, Harkema JR, Pestka JJ
Frontiers in immunology 2019;10:2851

Avian Flavivirus Infection of Monocytes/Macrophages by Extensive Subversion of Host Antiviral Innate Immune Responses.

Ma Y, Liang Y, Wang N, Cui L, Chen Z, Wu H, Zhu C, Wang Z, Liu S, Li H
Journal of virology 2019 Nov 15;93(22)

Long Noncoding RNA Lnc-MxA Inhibits Beta Interferon Transcription by Forming RNA-DNA Triplexes at Its Promoter.

Li X, Guo G, Lu M, Chai W, Li Y, Tong X, Li J, Jia X, Liu W, Qi D, Ye X
Journal of virology 2019 Nov 1;93(21)

Induction of interleukin 6 impairs the anti-HBV efficiency of IFN-α in human hepatocytes through upregulation of SOCS3.

Yang K, Guan S, Zhang H, Chen Z
Journal of medical virology 2019 May;91(5):803-812

Molecular cloning and transcriptional regulation of Indian peafowl (Pavo cristatus) IFN-α gene.

Wang Y, Zhao H, Liu J, Shao Y, Xing M
Cell stress & chaperones 2019 Mar;24(2):323-332

The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.

McFarlane S, Orr A, Roberts APE, Conn KL, Iliev V, Loney C, da Silva Filipe A, Smollett K, Gu Q, Robertson N, Adams PD, Rai TS, Boutell C
PLoS pathogens 2019 Mar;15(3):e1007667

Characterization, functional and signaling elucidation of pigeon (Columba livia) interferon-α: Knockdown p53 negatively modulates antiviral response.

Li S, Wang Y, Zhao H, Shao Y, Liu J, Xing M
Developmental and comparative immunology 2019 Jan;90:29-40

Interferon-alpha promotes immunosuppression through IFNAR1/STAT1 signalling in head and neck squamous cell carcinoma.

Ma H, Yang W, Zhang L, Liu S, Zhao M, Zhou G, Wang L, Jin S, Zhang Z, Hu J
British journal of cancer 2019 Feb;120(3):317-330

Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex.

Xu G, Xia Z, Deng F, Liu L, Wang Q, Yu Y, Wang F, Zhu C, Liu W, Cheng Z, Zhu Y, Zhou L, Zhang Y, Lu M, Liu S
PLoS pathogens 2019 Aug;15(8):e1008002

Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques.

Abdulhaqq SA, Martinez M, Kang G, Rodriguez IV, Nichols SM, Beaumont D, Joseph J, Azzoni L, Yin X, Wise M, Weiner D, Liu Q, Foulkes A, Münch J, Kirchhoff F, Coutifaris C, Tomaras GD, Sariol C, Marx PA, Li Q, Kraiselburd EN, Montaner LJ
Nature communications 2019 Aug 21;10(1):3753

NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.

Xia Z, Xu G, Nie L, Liu L, Peng N, He Q, Zuo Q, Zhou Y, Cao Z, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):1001-1011

Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.

He J, Liu H, Zhong J, Guo Z, Wu J, Zhang H, Huang Z, Jiang L, Li H, Zhang Z, Liu L, Wu Y, Qi L, Sun X, Cheng C
Neurobiology of disease 2018 Sep;117:114-124

Alcohol attenuates anti-HCV function of IFN-λ1 through up-regulation of PLASy expression in human hepatic cells.

Ran M, Huang J, Liang H, Jiang J, Liang B, Ning C, Zang N, Liao W, Liu H, Qin F, Yang Q, Ho W, Ye L, Chen H
Journal of medical virology 2018 Jun;90(6):1112-1120

Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation.

Wang H, Xin X, Wang M, Han L, Li J, Hao Y, Zheng C, Shen C
Archives of virology 2018 Jun;163(6):1429-1438

TBK1: A key regulator and potential treatment target for interferon positive Sjögren's syndrome, systemic lupus erythematosus and systemic sclerosis.

Bodewes ILA, Huijser E, van Helden-Meeuwsen CG, Tas L, Huizinga R, Dalm VASH, van Hagen PM, Groot N, Kamphuis S, van Daele PLA, Versnel MA
Journal of autoimmunity 2018 Jul;91:97-102

Characterization of Whooper Swan (Cygnus cygnus) Interferon α: Prokaryotic Expression, Biological Activities, and Physicochemical Characteristics.

Zhao H, Wang Y, Shao Y, Liu J, Li J, Zong H, Xing M
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2018 Jan;38(1):20-28

Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.

Luo W, Zhang J, Liang L, Wang G, Li Q, Zhu P, Zhou Y, Li J, Zhao Y, Sun N, Huang S, Zhou C, Chang Y, Cui P, Chen P, Jiang Y, Deng G, Bu Z, Li C, Jiang L, Chen H
PLoS pathogens 2018 Jan;14(1):e1006851

Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.

Alandijany T, Roberts APE, Conn KL, Loney C, McFarlane S, Orr A, Boutell C
PLoS pathogens 2018 Jan;14(1):e1006769

Type I IFN signature in childhood-onset systemic lupus erythematosus: a conspiracy of DNA- and RNA-sensing receptors?

Wahadat MJ, Bodewes ILA, Maria NI, van Helden-Meeuwsen CG, van Dijk-Hummelman A, Steenwijk EC, Kamphuis S, Versnel MA
Arthritis research & therapy 2018 Jan 10;20(1):4

Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma.

Ma H, Jin S, Yang W, Zhou G, Zhao M, Fang S, Zhang Z, Hu J
British journal of cancer 2018 Feb 20;118(4):509-521

The large GTPase Mx1 binds Kif5B for cargo transport along microtubules.

Ringer K, Riehl J, Müller M, Dewes J, Hoff F, Jacob R
Traffic (Copenhagen, Denmark) 2018 Dec;19(12):947-964

Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.

Xia Z, Xu G, Yang X, Peng N, Zuo Q, Zhu S, Hao H, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2017 May 1;198(9):3690-3704

Inducible Rubicon facilitates viral replication by antagonizing interferon production.

Wan Y, Cao W, Han T, Ren S, Feng J, Chen T, Wang J, Broering R, Lu M, Zhu Y
Cellular & molecular immunology 2017 Jul;14(7):607-620

Matrix Metalloproteinase 9 Facilitates Hepatitis B Virus Replication through Binding with Type I Interferon (IFN) Receptor 1 To Repress IFN/JAK/STAT Signaling.

Chen J, Xu W, Chen Y, Xie X, Zhang Y, Ma C, Yang Q, Han Y, Zhu C, Xiong Y, Wu K, Liu F, Liu Y, Wu J
Journal of virology 2017 Apr 15;91(8)

Soluble IL-6 Receptor and IL-27 Subunit p28 Protein Complex Mediate the Antiviral Response through the Type III IFN Pathway.

Yang X, Hao H, Xia Z, Xu G, Cao Z, Chen X, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2016 Sep 15;197(6):2369-81

Comparative Proteome Analysis of Porcine Jejunum Tissues in Response to a Virulent Strain of Porcine Epidemic Diarrhea Virus and Its Attenuated Strain.

Li Z, Chen F, Ye S, Guo X, Muhanmmad Memon A, Wu M, He Q
Viruses 2016 Nov 29;8(12)

STAT1 and NF-κB Inhibitors Diminish Basal Interferon-Stimulated Gene Expression and Improve the Productive Infection of Oncolytic HSV in MPNST Cells.

Jackson JD, Markert JM, Li L, Carroll SL, Cassady KA
Molecular cancer research : MCR 2016 May;14(5):482-92

Association of Increased Treg Cell Levels With Elevated Indoleamine 2,3-Dioxygenase Activity and an Imbalanced Kynurenine Pathway in Interferon-Positive Primary Sjögren's Syndrome.

Maria NI, van Helden-Meeuwsen CG, Brkic Z, Paulissen SM, Steenwijk EC, Dalm VA, van Daele PL, Martin van Hagen P, Kroese FG, van Roon JA, Harkin A, Dik WA, Drexhage HA, Lubberts E, Versnel MA
Arthritis & rheumatology (Hoboken, N.J.) 2016 Jul;68(7):1688-99

MxA Mediates SUMO-Induced Resistance to Vesicular Stomatitis Virus.

Maarifi G, Hannoun Z, Geoffroy MC, El Asmi F, Zarrouk K, Nisole S, Blondel D, Chelbi-Alix MK
Journal of virology 2016 Jul 15;90(14):6598-6610

Complex Interplay between HIV-1 Capsid and MX2-Independent Alpha Interferon-Induced Antiviral Factors.

Bulli L, Apolonia L, Kutzner J, Pollpeter D, Goujon C, Herold N, Schwarz SM, Giernat Y, Keppler OT, Malim MH, Schaller T
Journal of virology 2016 Aug 15;90(16):7469-7480

Human hepatitis B virus surface and e antigens inhibit major vault protein signaling in interferon induction pathways.

Liu S, Peng N, Xie J, Hao Q, Zhang M, Zhang Y, Xia Z, Xu G, Zhao F, Wang Q, Han T, Zhu Y
Journal of hepatology 2015 May;62(5):1015-23

Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis.

Brown SG, Knowell AE, Hunt A, Patel D, Bhosle S, Chaudhary J
The Prostate 2015 Feb 15;75(3):266-79

Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice.

Knight JS, Subramanian V, O'Dell AA, Yalavarthi S, Zhao W, Smith CK, Hodgin JB, Thompson PR, Kaplan MJ
Annals of the rheumatic diseases 2015 Dec;74(12):2199-206

Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication.

Bai L, Zhang W, Tan L, Yang H, Ge M, Zhu C, Zhang R, Cao Y, Chen J, Luo Z, Ho W, Liu F, Wu K, Wu J
Journal of molecular cell biology 2015 Dec;7(6):543-56

The large GTPase Mx1 is involved in apical transport in MDCK cells.

Hoff F, Greb C, Hollmann C, Hönig E, Jacob R
Traffic (Copenhagen, Denmark) 2014 Sep;15(9):983-96

NRAV, a long noncoding RNA, modulates antiviral responses through suppression of interferon-stimulated gene transcription.

Ouyang J, Zhu X, Chen Y, Wei H, Chen Q, Chi X, Qi B, Zhang L, Zhao Y, Gao GF, Wang G, Chen JL
Cell host & microbe 2014 Nov 12;16(5):616-26

Interferon induction of IFITM proteins promotes infection by human coronavirus OC43.

Zhao X, Guo F, Liu F, Cuconati A, Chang J, Block TM, Guo JT
Proceedings of the National Academy of Sciences of the United States of America 2014 May 6;111(18):6756-61

Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic Lupus erythematosus.

Yokogawa M, Takaishi M, Nakajima K, Kamijima R, Fujimoto C, Kataoka S, Terada Y, Sano S
Arthritis & rheumatology (Hoboken, N.J.) 2014 Mar;66(3):694-706

MxA as a clinically applicable biomarker for identifying systemic interferon type I in primary Sjogren's syndrome.

Maria NI, Brkic Z, Waris M, van Helden-Meeuwsen CG, Heezen K, van de Merwe JP, van Daele PL, Dalm VA, Drexhage HA, Versnel MA
Annals of the rheumatic diseases 2014 Jun;73(6):1052-9

IL-27, a cytokine, and IFN-λ1, a type III IFN, are coordinated to regulate virus replication through type I IFN.

Cao Y, Zhang R, Zhang W, Zhu C, Yu Y, Song Y, Wang Q, Bai L, Liu Y, Wu K, Wu J
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 15;192(2):691-703

Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration.

Reinhard C, Bottinelli D, Kim B, Luban J
Retrovirology 2014 Feb 1;11:12

Quantitative proteomic analysis reveals that transmissible gastroenteritis virus activates the JAK-STAT1 signaling pathway.

An K, Fang L, Luo R, Wang D, Xie L, Yang J, Chen H, Xiao S
Journal of proteome research 2014 Dec 5;13(12):5376-90

Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to viral replication by suppressing IFITM3 protein expression.

Wang S, Chi X, Wei H, Chen Y, Chen Z, Huang S, Chen JL
Journal of virology 2014 Aug;88(15):8375-85

Serial cervicovaginal exposures with replication-deficient SIVsm induce higher dendritic cell (pDC) and CD4+ T-cell infiltrates not associated with prevention but a more severe SIVmac251 infection of rhesus macaques.

Abdulhaqq SA, Martinez MI, Kang G, Foulkes AS, Rodriguez IV, Nichols SM, Hunter M, Sariol CA, Ruiz LA, Ross BN, Yin X, Speicher DW, Haase AT, Marx PA, Li Q, Kraiselburd EN, Montaner LJ
Journal of acquired immune deficiency syndromes (1999) 2014 Apr 1;65(4):405-13

MxA inhibits hepatitis B virus replication by interaction with hepatitis B core antigen.

Li N, Zhang L, Chen L, Feng W, Xu Y, Chen F, Liu X, Chen Z, Liu W
Hepatology (Baltimore, Md.) 2012 Sep;56(3):803-11

IFITM3 restricts the morbidity and mortality associated with influenza.

Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, GenISIS Investigators., MOSAIC Investigators., Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P
Nature 2012 Mar 25;484(7395):519-23

IFITM3 inhibits influenza A virus infection by preventing cytosolic entry.

Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen LM, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, Brass AL
PLoS pathogens 2011 Oct;7(10):e1002337

Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon.

Pertel T, Reinhard C, Luban J
Retrovirology 2011 Jun 22;8:49

Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections.

Jiang D, Weidner JM, Qing M, Pan XB, Guo H, Xu C, Zhang X, Birk A, Chang J, Shi PY, Block TM, Guo JT
Journal of virology 2010 Aug;84(16):8332-41

Rac1 is required for oncolytic NDV replication in human cancer cells and establishes a link between tumorigenesis and sensitivity to oncolytic virus.

Puhlmann J, Puehler F, Mumberg D, Boukamp P, Beier R
Oncogene 2010 Apr 15;29(15):2205-16

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse spleen tissue were subjected to SDS PAGE followed by western blot with 13750-1-AP(MX1 antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The MX1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MX1. This antibody recognizes human, mouse antigen. The MX1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 13750-1-AP.pdf

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