BS7490

antibody from Bioworld Technology, Inc

Targeting: TRAF7 DKFZp586I021, MGC7807, RFWD1, RNF119

Immunohistochemistry

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Validation data

Product number: BS7490 - Provider product page
Provider: Bioworld Technology, Inc
Product name: TRAF7 polyclonal antibody
Antibody type: Polyclonal
Antigen: Recombinant full length Human TRAF7.
Description: Tumor necrosis factor receptor-associated factor (TRAF) protein family members are critically involved in pathways triggered by tumor necrosis factor (TNF) receptors and Toll/interleukin-1 receptor (TIR)-containing receptors. TRAF7 contains an N-terminal RING and zinc finger domain and localizes to the cytoplasm and nucleus of cells in the M1 phase. TRAF7 activates IKKs-I?BÏ« and MKK3/6-p38 pathways which stimulate Toll-like receptor 2 (TLR2) signaling. TLR2 activates innate immunity, induces development of the acquired immunity, and also leads to the harmful inflammatory responses that can occur with infectious diseases. TRAF7 has E3 ubiquitin ligase activity, and it binds to the DNA-binding domain of the oncogenic c-Myb, via the WD40 repeats, and stimulates its sumoylation. This forces c-Myb to stay in the cytosol rather than the nucleus and thereby inhibits its activity. TRAF7 also stimulates MEKK3-mediated AP1 and CHOP activation and induces apoptosis.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

TRAF7 protein structure - BS7490 shown in red.