Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 11-8018 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-LST8/GBL Antibody
- Antibody type
- Polyclonal
- Description
- MLST8 or GbL (G protein beta protein subunit-like) is a subunit of mTORC1 and mTORC2 which regulates cell growth and survival. Both mTORC1 and 2 are activated in response to growth factors or amino acids but mTORC2 is most likely insensitive towards nutrients. Within mTORC1, LST8 interacts directly with mTOR and helps to enhance its kinase activity. mTORC1 phosphorylates EIF4EBP1 and thereby releasing it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. LST8/GBL more or less ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.
- Reactivity
- Human
- Host
- Rabbit
- Antigen sequence
A partial length recombinant LST8/G
BL protein (amino acids 100-320) wa
s used as the immunogen for this an
tibody.- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
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Supportive validation
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- ABEOMICS Inc. (provider)
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- Experimental details
- Western blot analysis of LST8/GBL. Anti-LST8/GBL (11-8018) was used at 1 µg/ml on Kidney lysate.