Antibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 17219-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17219-1-AP, RRID:AB_2112476
- Product name
- GPD2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated GPD2 antibody (Cat. #17219-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease.
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.
Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism.
Obesity and steatosis promotes mitochondrial remodeling that enhances respiratory capacity in the liver of ob/ob mice.
Mitochondrial remodeling in the liver following chronic alcohol feeding to rats.
A compound heterozygous mutation in GPD1 causes hepatomegaly, steatohepatitis, and hypertriglyceridemia.
A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase.
Liu S, Fu S, Wang G, Cao Y, Li L, Li X, Yang J, Li N, Shan Y, Cao Y, Ma Y, Dong M, Liu Q, Jiang H
Cell metabolism 2021 Oct 5;33(10):1974-1987.e9
Cell metabolism 2021 Oct 5;33(10):1974-1987.e9
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
Le Vasseur M, Friedman J, Jost M, Xu J, Yamada J, Kampmann M, Horlbeck MA, Salemi MR, Phinney BS, Weissman JS, Nunnari J
eLife 2021 May 26;10
eLife 2021 May 26;10
Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.
Langston PK, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei J, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Snyder NW, Horng T
Nature immunology 2019 Sep;20(9):1186-1195
Nature immunology 2019 Sep;20(9):1186-1195
Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism.
Alshawi A, Agius L
The Journal of biological chemistry 2019 Feb 22;294(8):2839-2853
The Journal of biological chemistry 2019 Feb 22;294(8):2839-2853
Obesity and steatosis promotes mitochondrial remodeling that enhances respiratory capacity in the liver of ob/ob mice.
Garcia J, Decker CW, Sanchez SJ, Ouk JM, Siu KM, Han D
FEBS letters 2018 Mar;592(6):916-927
FEBS letters 2018 Mar;592(6):916-927
Mitochondrial remodeling in the liver following chronic alcohol feeding to rats.
Han D, Johnson HS, Rao MP, Martin G, Sancheti H, Silkwood KH, Decker CW, Nguyen KT, Casian JG, Cadenas E, Kaplowitz N
Free radical biology & medicine 2017 Jan;102:100-110
Free radical biology & medicine 2017 Jan;102:100-110
A compound heterozygous mutation in GPD1 causes hepatomegaly, steatohepatitis, and hypertriglyceridemia.
Joshi M, Eagan J, Desai NK, Newton SA, Towne MC, Marinakis NS, Esteves KM, De Ferranti S, Bennett MJ, McIntyre A, Beggs AH, Berry GT, Agrawal PB
European journal of human genetics : EJHG 2014 Oct;22(10):1229-32
European journal of human genetics : EJHG 2014 Oct;22(10):1229-32
A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase.
Orr AL, Quinlan CL, Perevoshchikova IV, Brand MD
The Journal of biological chemistry 2012 Dec 14;287(51):42921-35
The Journal of biological chemistry 2012 Dec 14;287(51):42921-35
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 17219-1-AP(GPD2 antibody) at dilution of 1:800
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 17219-1-AP(GPD2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The GPD2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GPD2. This antibody recognizes human,mouse,rat antigen. The GPD2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.