FNab07501

antibody from FineTest Biotech
Targeting: RRP8 KIAA0409, NML
Provider product page for FNab07501
Western blot
ELISA
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
FNab07501 - Provider product page
Provider
FineTest Biotech
Product name
RRP8 antibody
Antibody type
Polyclonal
Antigen
Recombinant protein fragment
Description
Essential component of the eNoSC(energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9'(H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
ribosomal RNA processing 8, methylt
ransferase, homolog(yeast)
Epitope
IgG
Isotype
IgG
Vial size
100¦Ìg
Concentration
Immunogen affinity purified
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
RRP8 protein structure - FNab07501 shown in red.