Tissue expression
Cell line expression
Protein structure
TCIM
Transcriptional and immune response regulatorC8orf4, hTC-1, TC-1, TC1
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]
Top validated antibodies |
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Atlas Antibodies | HPA027188 | 1 references | Polyclonal |
ICC
IHC |
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Novus Biologicals | NBP1-81657 | 1 references | Polyclonal |
ICC
IHC |
|
Proteintech Group | 26279-1-AP | Polyclonal |
WB
EL
IHC
|
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LSBio | LS-C830553 | Polyclonal |
EL
IHC |
||
Biorbyt | orb156165 | Polyclonal |
EL
ICC
IHC
|
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider