Tissue expression
Cell line expression
Protein structure
TCIM
Transcriptional and immune response regulatorC8orf4, hTC-1, TC-1, TC1
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]
Top validated antibodies |
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Atlas Antibodies | ![]() |
1 references | Polyclonal |
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Novus Biologicals | ![]() |
1 references | Polyclonal |
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Proteintech Group | ![]() |
Polyclonal |
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LSBio | ![]() |
Polyclonal |
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Invitrogen Antibodies | ![]() |
Polyclonal |
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