BS7981

antibody from Bioworld Technology, Inc
Targeting: PIGA GPI3
Provider product page for BS7981
Western blot
Immunohistochemistry

Antibody data

Product number
BS7981 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PIGA polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human PIGA.
Description
Phosphatidylinositol-glycans (PIGs) are multi-pass transmembrane proteins that localize to the endoplasmic reticulum. PIGs are crucial for the synthesis of N-acetylglucosaminyl-phosphatidylinositol (GlcNAc-PI), a very early intermediate in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The PIG proteins are components of the GPI transamidase complex and play a role in the recognition of either the GPI attachment signal or the lipid portion of GPI. Phospha-tidylinositol glycan class A (PIG-A), an endoplasmic reticulum (ER) transmembrane protein, contains a large cytoplasmic domain, which displays homology to the bacterial GlcNAc transferase RfaK, and a small lumenal domain, which plays a role in targeting the PIG-A protein to the rough ER. PIG-A associates with PIG-C, PIG-H, PIG-P and PIG-Q, as well as DPM2, and interacts directly with PIG-Y. Defects in PIG-A cause paroxysmal nocturnal hemoglobinuria (PNH), an acquired genetic hematologic disorder.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PIGA protein structure - BS7981 shown in red.