Antibody data
- Antibody Data
- Antigen structure
- References [19]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11134-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11134-1-AP, RRID:AB_2289288
- Product name
- Aconitase 2 antibody
- Antibody type
- Polyclonal
- Description
- Aconitase 2 antibody (Cat. #11134-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Systemic phospho-defective and phospho-mimetic Drp1 mice exhibit normal growth and development with altered anxiety-like behavior.
Intermittent Theta Burst Stimulation Attenuates Cognitive Deficits and Alzheimer's Disease-Type Pathologies via ISCA1-Mediated Mitochondrial Modulation in APP/PS1 Mice.
UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation.
Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers.
Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth.
Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging.
Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2.
Cur@SF NPs alleviate Friedreich's ataxia in a mouse model through synergistic iron chelation and antioxidation.
Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.
Proteomic Profile of Sperm in Infertile Males Reveals Changes in Metabolic Pathways.
Bioenergetic functions in subpopulations of heart mitochondria are preserved in a non-obese type 2 diabetes rat model (Goto-Kakizaki).
The Symbiotic Relationship between the Neural Retina and Retinal Pigment Epithelium Is Supported by Utilizing Differential Metabolic Pathways.
Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75.
miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism.
Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.
Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.
A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.
Tumor Necrosis Factor-Associated Protein 1 (TRAP1) is Released from the Mitochondria Following 6-hydroxydopamine Treatment.
A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism.
Ikeda A, Iijima M, Sesaki H
iScience 2024 Jun 21;27(6):109874
iScience 2024 Jun 21;27(6):109874
Intermittent Theta Burst Stimulation Attenuates Cognitive Deficits and Alzheimer's Disease-Type Pathologies via ISCA1-Mediated Mitochondrial Modulation in APP/PS1 Mice.
Zhu Y, Huang H, Chen Z, Tao Y, Liao LY, Gao SH, Wang YJ, Gao CY
Neuroscience bulletin 2024 Feb;40(2):182-200
Neuroscience bulletin 2024 Feb;40(2):182-200
UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation.
Ahlstedt BA, Ganji R, Mukkavalli S, Paulo JA, Gygi SP, Raman M
EMBO reports 2024 Feb;25(2):672-703
EMBO reports 2024 Feb;25(2):672-703
Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers.
Liu C, Chen L, Cong Y, Cheng L, Shuai Y, Lv F, Chen K, Song Y, Xing Y
Cell death & disease 2024 Feb 16;15(2):149
Cell death & disease 2024 Feb 16;15(2):149
Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth.
Zhao H, Zhang M, Zhang J, Sun Z, Zhang W, Dong W, Cheng C, Yao Y, Li K
Cell & bioscience 2023 May 13;13(1):87
Cell & bioscience 2023 May 13;13(1):87
Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging.
Yuan M, Wang Y, Wen J, Jing F, Zou Q, Pu Y, Pan T, Cai Z
Aging and disease 2022 Oct 1;13(5):1532-1545
Aging and disease 2022 Oct 1;13(5):1532-1545
Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2.
Sun LY, Lyu YY, Zhang HY, Shen Z, Lin GQ, Geng N, Wang YL, Huang L, Feng ZH, Guo X, Lin N, Ding S, Yuan AC, Zhang L, Qian K, Pu J
Circulation 2022 Nov 22;146(21):1591-1609
Circulation 2022 Nov 22;146(21):1591-1609
Cur@SF NPs alleviate Friedreich's ataxia in a mouse model through synergistic iron chelation and antioxidation.
Xu L, Sun Z, Xing Z, Liu Y, Zhao H, Tang Z, Luo Y, Hao S, Li K
Journal of nanobiotechnology 2022 Mar 9;20(1):118
Journal of nanobiotechnology 2022 Mar 9;20(1):118
Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.
Wang YP, Sharda A, Xu SN, van Gastel N, Man CH, Choi U, Leong WZ, Li X, Scadden DT
Cell metabolism 2021 May 4;33(5):1027-1041.e8
Cell metabolism 2021 May 4;33(5):1027-1041.e8
Proteomic Profile of Sperm in Infertile Males Reveals Changes in Metabolic Pathways.
Liang J, Zheng Y, Zeng W, Chen L, Yang S, Du P, Wang Y, Yu X, Zhang X
The protein journal 2021 Dec;40(6):929-939
The protein journal 2021 Dec;40(6):929-939
Bioenergetic functions in subpopulations of heart mitochondria are preserved in a non-obese type 2 diabetes rat model (Goto-Kakizaki).
Lai N, Kummitha CM, Loy F, Isola R, Hoppel CL
Scientific reports 2020 Mar 25;10(1):5444
Scientific reports 2020 Mar 25;10(1):5444
The Symbiotic Relationship between the Neural Retina and Retinal Pigment Epithelium Is Supported by Utilizing Differential Metabolic Pathways.
Sinha T, Naash MI, Al-Ubaidi MR
iScience 2020 Apr 24;23(4):101004
iScience 2020 Apr 24;23(4):101004
Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75.
Li C, Chen W, Zheng L, Zhang B, Yang X, Zhang Q, Wang N, Wang Y, Yang J, Sha J, Zhou Z, Li X, Li Y, Shen XL
Toxicon : official journal of the International Society on Toxinology 2019 Oct;168:141-146
Toxicon : official journal of the International Society on Toxinology 2019 Oct;168:141-146
miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism.
Muys BR, Sousa JF, Plaça JR, de Araújo LF, Sarshad AA, Anastasakis DG, Wang X, Li XL, de Molfetta GA, Ramão A, Lal A, Vidal DO, Hafner M, Silva WA
Cancer research 2019 Jul 1;79(13):3294-3305
Cancer research 2019 Jul 1;79(13):3294-3305
Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.
Li H, Zhao H, Hao S, Shang L, Wu J, Song C, Meyron-Holtz EG, Qiao T, Li K
Scientific reports 2018 Mar 23;8(1):5118
Scientific reports 2018 Mar 23;8(1):5118
Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.
Chen CM, Wu YR, Chang KH
International journal of molecular sciences 2017 Nov 21;18(11)
International journal of molecular sciences 2017 Nov 21;18(11)
A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.
Pryde KR, Taanman JW, Schapira AH
Cell reports 2016 Dec 6;17(10):2522-2531
Cell reports 2016 Dec 6;17(10):2522-2531
Tumor Necrosis Factor-Associated Protein 1 (TRAP1) is Released from the Mitochondria Following 6-hydroxydopamine Treatment.
Shin DI, Oh YJ
Experimental neurobiology 2014 Mar;23(1):65-76
Experimental neurobiology 2014 Mar;23(1):65-76
A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism.
Cai Z, Zhao JS, Li JJ, Peng DN, Wang XY, Chen TL, Qiu YP, Chen PP, Li WJ, Xu LY, Li EM, Tam JP, Qi RZ, Jia W, Xie D
Molecular & cellular proteomics : MCP 2010 Dec;9(12):2617-28
Molecular & cellular proteomics : MCP 2010 Dec;9(12):2617-28
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 11134-1-AP(ACO2 antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Aconitase 2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Aconitase 2. This antibody recognizes human,mouse,rat antigen. The Aconitase 2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.