17670-1-AP

antibody from Proteintech Group

Targeting: JAK2 JTK10

Provider product page for 17670-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [53]
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Validations
Western blot [1]

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Product number: 17670-1-AP - Provider product page
Provider: Proteintech Group
Product name: JAK2 antibody
Antibody type: Polyclonal
Description: KD/KO validated JAK2 antibody (Cat. #17670-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

JAK2 protein structure - 17670-1-AP shown in red.

Submitted references Inhibition of JAK-STAT Signaling Pathway Alleviates Age-Related Phenotypes in Tendon Stem/Progenitor Cells.

Chen M, Xiao L, Dai G, Lu P, Zhang Y, Li Y, Ni M, Rui Y
Frontiers in cell and developmental biology 2021;9:650250

Trefoil Factor 3 Inhibits Thyroid Cancer Cell Progression Related to IL-6/JAK/STAT3 Signaling Pathway.

Xin Y, Shang X, Sun X, Liu Y, Xu G, Xue G
Evidence-based complementary and alternative medicine : eCAM 2021;2021:2130229

Effects and Molecular Mechanism of Single-Nucleotide Polymorphisms of MEG3 on Porcine Skeletal Muscle Development.

Yang R, Liu Y, Cheng Y, Wang C, Song J, Lu G, Feng T, Wang S, Sun X, Meng J, Hao L
Frontiers in genetics 2021;12:607910

CTR9-mediated JAK2/STAT3 pathway promotes the proliferation, migration, and invasion of human glioma cells.

Xu Y, Chen J, He G, Zhang Y
Journal of clinical laboratory analysis 2021 Sep;35(9):e23943

Chorionic villus-derived mesenchymal stem cell-mediated autophagy promotes the proliferation and invasiveness of trophoblasts under hypoxia by activating the JAK2/STAT3 signalling pathway.

Chu Y, Zhu C, Yue C, Peng W, Chen W, He G, Liu C, Lv Y, Gao G, Yao K, Han R, Hu X, Zhang Y, Ye Y
Cell & bioscience 2021 Oct 13;11(1):182

Src acts as the target of matrine to inhibit the proliferation of cancer cells by regulating phosphorylation signaling pathways.

Zhang X, Xu H, Bi X, Hou G, Liu A, Zhao Y, Wang G, Cao X
Cell death & disease 2021 Oct 12;12(10):931

Differential effects of EPA and DHA on DSS-induced colitis in mice and possible mechanisms involved.

Zhang Z, Xue Z, Yang H, Zhao F, Liu C, Chen J, Lu S, Zou Z, Zhou Y, Zhang X
Food & function 2021 Mar 1;12(4):1803-1817

Effect of SOCS3 on apoptosis of human trophoblasts via adjustment of the JAK2/STAT3 signaling pathway in preterm birth.

Yin Y, Qu L, Zhu D, Wu Y, Zhou X
Translational pediatrics 2021 Jun;10(6):1637-1646

A metabolic data-driven systems pharmacology strategy for decoding and validating the mechanism of Compound Kushen Injection against HCC.

Wang KX, Chen YP, Lu AP, Du GH, Qin XM, Guan DG, Gao L
Journal of ethnopharmacology 2021 Jun 28;274:114043

Daphnetin ameliorates acute lung injury in mice with severe acute pancreatitis by inhibiting the JAK2-STAT3 pathway.

Yang S, Song Y, Wang Q, Liu Y, Wu Z, Duan X, Zhang Y, Bi X, Geng Y, Chen S, Zhu C
Scientific reports 2021 Jun 1;11(1):11491

The Protective Effects of Parathyroid Hormone (1-34) on Cartilage and Subchondral Bone Through Down-Regulating JAK2/STAT3 and WNT5A/ROR2 in a Collagenase-Induced Osteoarthritis Mouse Model.

Shao LT, Gou Y, Fang JK, Hu YP, Lian QQ, Yang Z, Zhang YY, Wang YD, Tian FM, Zhang L
Orthopaedic surgery 2021 Jul;13(5):1662-1672

Baicalein Delays H₂O₂-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism.

Gao L, Zheng WG, Wu XK, Du GH, Qin XM
ACS chemical neuroscience 2021 Jul 7;12(13):2320-2335

Blockade of JAK2 signaling produces immunomodulatory effect to preserve pancreatic homeostasis in severe acute pancreatitis.

Qiu Z, Xu F, Wang Z, Yang P, Bu Z, Cheng F, Jiang H, Li L, Zhang F
Biochemistry and biophysics reports 2021 Dec;28:101133

A comprehensive genome-wide analysis of long non-coding RNA and mRNA expression profiles of JAK2V617F-positive classical myeloproliferative neoplasms.

Zhou J, Wu H, Guo C, Li B, Zhou LL, Liang AB, Fu JF
Bioengineered 2021 Dec;12(2):10564-10586

Helicobacter pylori induces gastric cancer via down-regulating miR-375 to inhibit dendritic cell maturation.

Zhang Z, Chen S, Fan M, Ruan G, Xi T, Zheng L, Guo L, Ye F, Xing Y
Helicobacter 2021 Aug;26(4):e12813

Mild Hypothermia Attenuates Hepatic Ischemia-Reperfusion Injury through Regulating the JAK2/STAT3-CPT1a-Dependent Fatty Acid β-Oxidation.

Wang W, Hu X, Xia Z, Liu Z, Zhong Z, Lu Z, Liu A, Ye S, Cao Q, Wang Y, Zhu F, Ye Q
Oxidative medicine and cellular longevity 2020;2020:5849794

Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway.

Xiang S, Chen K, Xu L, Wang T, Guo C
Drug design, development and therapy 2020;14:129-143

Selaginellin B induces apoptosis and autophagy in pancreatic cancer cells via the JAK2/STAT3 signaling pathway.

Chu P, Wang S, Zhu X, Yang Y, Li H, Tesfaldet T, Shopit A, Yang Y, Ma X, Peng J, Tang Z, Sun Z
American journal of translational research 2020;12(11):7127-7143

Csf2 Attenuated Sepsis-Induced Acute Kidney Injury by Promoting Alternative Macrophage Transition.

Li Y, Zhai P, Zheng Y, Zhang J, Kellum JA, Peng Z
Frontiers in immunology 2020;11:1415

Combination therapy with ropivacaine-loaded liposomes and nutrient deprivation for simultaneous cancer therapy and cancer pain relief.

Zhang J, Zhu S, Tan Q, Cheng D, Dai Q, Yang Z, Zhang L, Li F, Zuo Y, Dai W, Chen L, Gu E, Xu G, Wei Z, Cao Y, Liu X
Theranostics 2020;10(11):4885-4899

Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.

Kang N, Cao S, Jiang B, Zhang Q, Donkor PO, Zhu Y, Qiu F, Gao X
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885

USP9X promotes the proliferation, invasion and metastasis of liver cancer cells through regulating the JAK2/STAT3 signaling.

Song X, Yang W, Wu C, Han Y, Lu Y
Oncology letters 2020 Sep;20(3):2897-2905

Parathyroid hormone (1-34) ameliorates cartilage degeneration and subchondral bone deterioration in collagenase-induced osteoarthritis model in mice.

Shao LT, Gou Y, Fang JK, Hu YP, Lian QQ, Zhang YY, Wang YD, Tian FM, Zhang L
Bone & joint research 2020 Oct;9(10):675-688

Fucoidan from Fucus vesiculosus attenuates doxorubicin-induced acute cardiotoxicity by regulating JAK2/STAT3-mediated apoptosis and autophagy.

Zhang J, Sun Z, Lin N, Lu W, Huang X, Weng J, Sun S, Zhang C, Yang Q, Zhou G, Guo H, Chi J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110534

SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway.

Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Connor JH, Douam F, Emili A, Saeed M
bioRxiv : the preprint server for biology 2020 Oct 28;

SUMO4 small interfering RNA attenuates invasion and migration via the JAK2/STAT3 pathway in non-small cell lung cancer cells.

Liang JX, Gao W, Zeng XW, Cheng GP, Cai L, Tao KY, Yang X
Oncology letters 2020 Nov;20(5):225

AQP1 modulates tendon stem/progenitor cells senescence during tendon aging.

Chen M, Li Y, Xiao L, Dai G, Lu P, Wang Y, Rui Y
Cell death & disease 2020 Mar 18;11(3):193

Graphene oxide nanoparticles induce hepatic dysfunction through the regulation of innate immune signaling in zebrafish (Danio rerio).

Xiong G, Deng Y, Liao X, Zhang J, Cheng B, Cao Z, Lu H
Nanotoxicology 2020 Jun;14(5):667-682

Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.

Dong X, Wu D, Zhang Y, Jia L, Pan X, Sun J, Pan LL
Antioxidants (Basel, Switzerland) 2020 Jun 5;9(6)

Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5.

Zhang Y, Zhou L, Zhang Z, Xu Q, Han X, Zhao Y, Song X, Zhao T, Ye L
Environmental science and pollution research international 2020 Feb;27(4):3837-3848

Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway.

Ren S, Xing Y, Wang C, Jiang F, Liu G, Li Z, Jiang T, Zhu Y, Piao D
The international journal of biochemistry & cell biology 2020 Aug;125:105777

STIP1 Regulates Proliferation and Migration of Lung Adenocarcinoma Through JAK2/STAT3 Signaling Pathway.

Guo X, Yan Z, Zhang G, Wang X, Pan Y, Huang M
Cancer management and research 2019;11:10061-10072

Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin.

Zhang S, Zhou L, Zhang M, Wang Y, Wang M, Du J, Gu W, Kui F, Li J, Geng S, Du G
Frontiers in pharmacology 2019;10:1658

Interleukin-6: Its role and mechanisms in rescuing depression-like behaviors in rat models of depression.

Wang P, Feng YB, Wang L, Li Y, Fan C, Song Q, Yu SY
Brain, behavior, and immunity 2019 Nov;82:106-121

Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.

Zhang Y, Wang S, Zhao T, Yang L, Guo S, Shi Y, Zhang X, Zhou L, Ye L
Ecotoxicology and environmental safety 2019 Nov 30;184:109611

FGFR2 Promotes Expression of PD-L1 in Colorectal Cancer via the JAK/STAT3 Signaling Pathway.

Li P, Huang T, Zou Q, Liu D, Wang Y, Tan X, Wei Y, Qiu H
Journal of immunology (Baltimore, Md. : 1950) 2019 May 15;202(10):3065-3075

Inhibition of Connexin43 hemichannels with Gap19 protects cerebral ischemia/reperfusion injury via the JAK2/STAT3 pathway in mice.

Chen B, Yang L, Chen J, Chen Y, Zhang L, Wang L, Li X, Li Y, Yu H
Brain research bulletin 2019 Mar;146:124-135

Effect of Konjac Mannan Oligosaccharides on Glucose Homeostasis via the Improvement of Insulin and Leptin Resistance In Vitro and In Vivo.

Zhu D, Yan Q, Li Y, Liu J, Liu H, Jiang Z
Nutrients 2019 Jul 24;11(8)

Toxicological exploration of peptide-based cationic liposomes in siRNA delivery.

Zhu Y, Meng Y, Zhao Y, Zhu J, Xu H, Zhang E, Shi L, Du L, Liu G, Zhang C, Xu X, Kang X, Zhen Y, Zhang S
Colloids and surfaces. B, Biointerfaces 2019 Jul 1;179:66-76

Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death.

Xie L, Zeng Y, Dai Z, He W, Ke H, Lin Q, Chen Y, Bu J, Lin D, Zheng M
International journal of biological sciences 2018;14(5):577-585

Triptolide delays disease progression in an adult rat model of polycystic kidney disease through the JAK2-STAT3 pathway.

Jing Y, Wu M, Zhang D, Chen D, Yang M, Mei S, He L, Gu J, Qi N, Fu L, Li L, Mei C
American journal of physiology. Renal physiology 2018 Sep 1;315(3):F479-F486

Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis.

Pan H, Fu C, Huang L, Jiang Y, Deng X, Guo J, Su Z
Marine drugs 2018 Jun 5;16(6)

Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.

Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z
Journal of cellular physiology 2018 Jan;234(1):777-788

Protocatechuic aldehyde protects against isoproterenol-induced cardiac hypertrophy via inhibition of the JAK2/STAT3 signaling pathway.

Fang X, Liu Y, Lu J, Hong H, Yuan J, Zhang Y, Wang P, Liu P, Ye J
Naunyn-Schmiedeberg's archives of pharmacology 2018 Dec;391(12):1373-1385

CEP55 Promotes Cell Motility via JAK2⁻STAT3⁻MMPs Cascade in Hepatocellular Carcinoma.

Li M, Gao J, Li D, Yin Y
Cells 2018 Aug 8;7(8)

Effects of apigenin pretreatment against renal ischemia/reperfusion injury via activation of the JAK2/STAT3 pathway.

Liu Y, Wang L, Du Y, Chen Z, Guo J, Weng X, Wang X, Wang M, Chen D, Liu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:1799-1808

Effect of modified Xiaochaihu decoction‑containing serum on HepG2.2.15 cells via the JAK2/STAT3 signaling pathway.

Chen S, Wang Z, Wan S, Huang H, Liang H
Molecular medicine reports 2017 Nov;16(5):7416-7422

Propofol enhances the cisplatin-induced apoptosis on cervical cancer cells via EGFR/JAK2/STAT3 pathway.

Li H, Lu Y, Pang Y, Li M, Cheng X, Chen J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Feb;86:324-333

Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.

Song Y, Kong L, Sun B, Gao L, Chu P, Ahsan A, Qaed E, Lin Y, Peng J, Ma X, Zhang J, Wang S, Tang Z
Cell biology international 2017 Dec;41(12):1367-1378

IL-6 promotes epithelial-to-mesenchymal transition of human peritoneal mesothelial cells possibly through the JAK2/STAT3 signaling pathway.

Xiao J, Gong Y, Chen Y, Yu D, Wang X, Zhang X, Dou Y, Liu D, Cheng G, Lu S, Yuan W, Li Y, Zhao Z
American journal of physiology. Renal physiology 2017 Aug 1;313(2):F310-F318

Oral kanglaite injection (KLTI) attenuates the lung cancer-promoting effect of high-fat diet (HFD)-induced obesity.

Cao N, Ma X, Guo Z, Zheng Y, Geng S, Meng M, Du Z, Lin H, Duan Y, Du G
Oncotarget 2016 Sep 20;7(38):61093-61106

The salicylanilide derivatives inhibit signal transducer and activator of transcription 3 pathways in A549 lung cancer cells.

Hu M, Ye W, Li J, Zhou P, Chu Z, Huang W
Anti-cancer drugs 2016 Jan;27(1):41-7

Paper-based microreactor array for rapid screening of cell signaling cascades.

Huang CH, Lei KF, Tsang NM
Lab on a chip 2016 Aug 7;16(15):2911-20

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The JAK2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human JAK2. This antibody recognizes human,mouse,rat antigen. The JAK2 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 17670-1-AP.pdf

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