Tissue expression
Cell line expression
Protein structure
STAP1
Signal transducing adaptor family member 1BRDG1, STAP-1
The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Top validated antibodies |
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LSBio | ![]() |
Polyclonal |
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Abnova Corporation | ![]() |
3 references | Polyclonal |
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antibodies-online | ![]() |
Polyclonal |
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Invitrogen Antibodies | ![]() |
Polyclonal |
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Aviva Systems Biology | ![]() |
Polyclonal |
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