CABT-BL8452
antibody from Creative Diagnostics
Targeting: CD274
B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- CABT-BL8452 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Anti-PD-L1 monoclonal antibody, clone 8G3
- Antibody type
- Monoclonal
- Description
- Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and nonhematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1(PD1). During infection or inflammation, PD1- PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PDL1 has become an important biomarker and immunotherapy target for many types of malignancies.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 8G3
- Vial size
- 50ul, 100ul
- Storage
- This antibody is shipped at 4°C. This product is stable for 12 months from date of receipt when stored at -20°C to -70°C. Avoid freeze/thaw cycles.
No comments: Submit comment
No validations: Submit validation data