10-7562-25

antibody from ABEOMICS Inc.

Targeting: CD274 B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1

Antibody data

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Validation data

Product number: 10-7562-25 - Provider product page
Provider: ABEOMICS Inc.
Product name: Anti-Human PD-L1 Antibody
Antibody type: Monoclonal
Description: PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belongs to the B7 superfamily that inhibits immune responses through its receptor, PD-1 and PD-L1 play a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation and in numerous autoimmune diseases.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Antigen sequence: A partial length recombinant PDL1 p rotein (amino acids 18-227) was use d as the immunogen for this antibod y.
Isotype: IgG
Antibody clone number: ABM4E54
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing

CD274 protein structure - 10-7562-25 shown in red.