abx001385

antibody from Abbexa

Targeting: CD274 B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

abx001385

Provider

Abbexa

Product name

Programmed Cell Death Protein 1 Ligand 1 / PD-L1 (CD274) Antibody

Antibody type

Polyclonal

Description

Programmed Cell Death 1 Ligand 1 Antibody is a Rabbit Polyclonal antibody against PD-L1 (CD274). Programmed cell death ligand 1 (CD274, or B7-H1, PD-L1) is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

3 mg/ml

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.