677002

antibody from BioLegend
Targeting: LDLR LDLCQ2
Provider product page for 677002

Antibody data

Product number
677002 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#677002, RRID:AB_2565724
Product name
Purified anti-LDLR
Antibody type
Monoclonal
Antigen
Recombinant human LDLR produced in the 293E cell line.
Description
Elevated LDL is a prevalent risk factor for coronary artery disease and other atherosclerotic diseases, which constitutes the largest cause of mortality in the United States. LDLR that is localized on hepatocytes plays an important role in removing cholesterol-transporting LDL from the plasma by receptor-mediated endocytosis. LDLR is constitutively expressed and binds ApoB of LDL and ApoE of VLDL, and is also responsible for clearing 70% of plasma LDL in liver. Human LDLR shares 78% amino acid homology with its mouse counterpart. Mutations in the LDLR gene have been shown to cause familial hypercholesterolemia, which are inherited in an autosomal dominant pattern.
Reactivity
Human, Mouse
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
M3805D06
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
LDLR protein structure - 677002 shown in red.