Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 677002 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#677002, RRID:AB_2565724
- Product name
- Purified anti-LDLR
- Antibody type
- Monoclonal
- Antigen
- Recombinant human LDLR produced in the 293E cell line.
- Description
- Elevated LDL is a prevalent risk factor for coronary artery disease and other atherosclerotic diseases, which constitutes the largest cause of mortality in the United States. LDLR that is localized on hepatocytes plays an important role in removing cholesterol-transporting LDL from the plasma by receptor-mediated endocytosis. LDLR is constitutively expressed and binds ApoB of LDL and ApoE of VLDL, and is also responsible for clearing 70% of plasma LDL in liver. Human LDLR shares 78% amino acid homology with its mouse counterpart. Mutations in the LDLR gene have been shown to cause familial hypercholesterolemia, which are inherited in an autosomal dominant pattern.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Antibody clone number
- M3805D06
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Western blot analysis of recombinant human LDLR (lane 1) and 3T3-L1 (lane 2) using anti-LDLR antibody (clone M3805D06).
- Conjugate
- Unconjugated