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- Antibody Data
- Antigen structure
- References [125]
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- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
- Flow cytometry [1]
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- Product number
- 12063-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12063-1-AP, RRID:AB_878040
- Product name
- KRAS antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated KRAS antibody (Cat. #12063-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting the molecular chaperone CCT2 inhibits GBM progression by influencing KRAS stability.
Carbene Footprinting Directs Design of Genetically Encoded Proximity-Reactive Protein Binders.
Classical prescription Floris Sophorae Powder treat colorectal cancer by regulating KRAS/MEK-ERK signaling pathway.
Reporter cell lines to screen for inhibitors or regulators of the KRAS-RAF-MEK1/2-ERK1/2 pathway.
TGFβ1-induced hedgehog signaling suppresses the immune response of brain microvascular endothelial cells elicited by meningitic Escherichia coli.
Cytoplasmic localization of SETDB1‑induced Warburg effect via c‑MYC‑LDHA axis enhances migration and invasion in breast carcinoma.
The CTLH Ubiquitin Ligase Substrates ZMYND19 and MKLN1 Negatively Regulate mTORC1 at the Lysosomal Membrane.
A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice.
Disruption of the pro-oncogenic c-RAF-PDE8A complex represents a differentiated approach to treating KRAS-c-RAF dependent PDAC.
miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb the Proliferation and Functions of Chondrocytes.
Spermine-Based Poly(β-amino ester)s for siRNA Delivery against Mutated KRAS in Lung Cancer.
Oncogenic BRAF noncanonically promotes tumor metastasis by mediating VASP phosphorylation and filopodia formation.
Gold Nanoparticles Inhibit Macropinocytosis by Decreasing KRAS Activation.
An unconventional cancer-promoting function of methamphetamine in hepatocellular carcinoma.
Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer.
LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL.
HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis.
RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
A TEAD2-Driven Endothelial-Like Program Shapes Basal-Like Differentiation and Metastasis of Pancreatic Cancer.
Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells.
A First-Class Degrader Candidate Targeting Both KRAS G12D and G12V Mediated by CANDDY Technology Independent of Ubiquitination.
The miR-143/145 cluster induced by TGF-β1 suppresses Wilms' tumor 1 expression in cultured human podocytes.
Reversibility and developmental neuropathology of linear nevus sebaceous syndrome caused by dysregulation of the RAS pathway.
Association of KRAS, NRAS, BRAF and PIK3CA gene mutations with clinicopathological features, prognosis and ring finger protein 215 expression in patients with colorectal cancer.
Nutlin-3a induces KRAS mutant/p53 wild type lung cancer specific methuosis-like cell death that is dependent on GFPT2.
A proteomic signature and potential pharmacological opportunities in the adaptive resistance to MEK and PI3K kinase inhibition in pancreatic cancer cells.
Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.
Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival.
Promoted Skin Wound Healing by Tail-Amputated Eisenia foetida Proteins via the Ras/Raf/MEK/ERK Signaling Pathway.
Ribitol alters multiple metabolic pathways of central carbon metabolism with enhanced glycolysis: A metabolomics and transcriptomics profiling of breast cancer.
Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence.
Natural product manoalide promotes EGFR-TKI sensitivity of lung cancer cells by KRAS-ERK pathway and mitochondrial Ca(2+) overload-induced ferroptosis.
New mechanistic insights into the RAS-SIN1 interaction at the membrane.
Mycoplasma gallisepticum induced exosomal gga-miR-193a to disturb cell proliferation, apoptosis, and cytokine production by targeting the KRAS/ERK signaling pathway.
Identification of MYEOV-Associated Gene Network as a Potential Therapeutic Target in Pancreatic Cancer.
Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.
Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway.
Regulation of GTPase function by autophosphorylation.
Hyaluronic Acid-Modified Nanoparticles Self-Assembled from Linoleic Acid-Conjugated Chitosan for the Codelivery of miR34a and Doxorubicin in Resistant Breast Cancer.
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone provokes progression from chronic pancreatitis to pancreatic intraepithelial neoplasia.
Ionic Liquid-Based Extraction System for In-Depth Analysis of Membrane Protein Complexes.
PD-L1/PD-L1 signalling promotes colorectal cancer cell migration ability through RAS/MEK/ERK.
Redox-sensitive small GTPase H-Ras in murine astrocytes, an in vitro study.
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells.
Oncogenic Kras-Mediated Cytokine CCL15 Regulates Pancreatic Cancer Cell Migration and Invasion through ROS.
LncRNA IGFL2-AS1 Promotes the Proliferation, Migration, and Invasion of Colon Cancer Cells and is Associated with Patient Prognosis.
JMJD8 Promotes Malignant Progression of Lung Cancer by Maintaining EGFR Stability and EGFR/PI3K/AKT Pathway Activation.
Hsa-miR-557 Inhibits Osteosarcoma Growth Through Targeting KRAS.
YRDC Mediates the Resistance of Lenvatinib in Hepatocarcinoma Cells via Modulating the Translation of KRAS.
Discovery of a New CDK4/6 and PI3K/AKT Multiple Kinase Inhibitor Aminoquinol for the Treatment of Hepatocellular Carcinoma.
Identification and Confirmation of the miR-30 Family as a Potential Central Player in Tobacco-Related Head and Neck Squamous Cell Carcinoma.
Quadruple-editing of the MAPK and PI3K pathways effectively blocks the progression of KRAS-mutated colorectal cancer cells.
PFP@PLGA/Cu(12)Sb(4)S(13)-mediated PTT ablates hepatocellular carcinoma by inhibiting the RAS/MAPK/MT-CO1 signaling pathway.
The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation.
In vivo self-assembled small RNAs as a new generation of RNAi therapeutics.
A novel circular RNA, circPUS7 promotes cadmium-induced transformation of human bronchial epithelial cells by regulating Kirsten rat sarcoma viral oncogene homolog expression via sponging miR-770.
Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling.
CEP164 Deficiency Causes Hyperproliferation of Pancreatic Cancer Cells.
Comparison of anticarcinogenic properties of Viburnum opulus and its active compound p-coumaric acid on human colorectal carcinoma.
Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics.
Precise and efficient silencing of mutant Kras(G12D) by CRISPR-CasRx controls pancreatic cancer progression.
Ubiquitin-binding associated protein 2 regulates KRAS activation and macropinocytosis in pancreatic cancer.
Siah2 integrates mitogenic and extracellular matrix signals linking neuronal progenitor ciliogenesis with germinal zone occupancy.
Establishment and Characterization of Immortalized Miniature Pig Pancreatic Cell Lines Expressing Oncogenic K-Ras(G12D).
Discovery of Turn-On Fluorescent Probes for Detecting PDEδ Protein in Living Cells and Tumor Slices.
Immunohistochemical assessment of growth factor signaling molecules: MAPK, Akt, and STAT3 pathways in oral epithelial precursor lesions and squamous cell carcinoma.
VPS33B negatively modulated by nicotine functions as a tumor suppressor in colorectal cancer.
Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions.
Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening.
Ribosome profiling analysis identified a KRAS-interacting microprotein that represses oncogenic signaling in hepatocellular carcinoma cells.
DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas.
Cell-type specific tumorigenesis with Ras oncogenes in human lung epithelial cells.
RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer.
UBN2 promotes tumor progression via the Ras/MAPK pathway and predicts poor prognosis in colorectal cancer.
Apigenin Combined With Gefitinib Blocks Autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells.
ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer.
Characterization of Protein Profiling and mRNA Expression of LLC Exosomes.
The development of a cell-based model for the assessment of carcinogenic potential upon long-term PM2.5 exposure.
MEK nuclear localization promotes YAP stability via sequestering β-TrCP in KRAS mutant cancer cells.
Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors.
KRAS regulation by small non-coding RNAs and SNARE proteins.
Effectiveness of a genetic test panel designed for gynecological cancer: an exploratory study.
Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer.
HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform to Reveal IAP Antagonists as Anti-cancer Immune Enhancers.
Long noncoding RNA PCAT1, a novel serum-based biomarker, enhances cell growth by sponging miR-326 in oesophageal squamous cell carcinoma.
Zoledronic acid enhances the efficacy of the MEK inhibitor trametinib in KRAS mutant cancers.
Final-2 targeted glycolysis mediated apoptosis and autophagy in human lung adenocarcinoma cells but failed to inhibit xenograft in nude mice.
SHIP1 inhibits cell growth, migration, and invasion in non‑small cell lung cancer through the PI3K/AKT pathway.
Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition.
Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells.
Genome-wide transcriptional analysis of BRD4-regulated genes and pathways in human glioma U251 cells.
Impairment of K-Ras signaling networks and increased efficacy of epidermal growth factor receptor inhibitors by a novel synthetic miR-143.
Mutant KRAS promotes liver metastasis of colorectal cancer, in part, by upregulating the MEK-Sp1-DNMT1-miR-137-YB-1-IGF-IR signaling pathway.
Overexpression of miR-19a inhibits colorectal cancer angiogenesis by suppressing KRAS expression.
Nogo-B receptor promotes epithelial-mesenchymal transition in non-small cell lung cancer cells through the Ras/ERK/Snail1 pathway.
Lin28B facilitates the progression and metastasis of pancreatic ductal adenocarcinoma.
The transcription factor HOXB7 regulates ERK kinase activity and thereby stimulates the motility and invasiveness of pancreatic cancer cells.
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
Low-Dose Farnesyltransferase Inhibitor Suppresses HIF-1α and Snail Expression in Triple-Negative Breast Cancer MDA-MB-231 Cells In Vitro.
HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma.
Oncogenic KRAS Targets MUC16/CA125 in Pancreatic Ductal Adenocarcinoma.
Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways.
miR-450b-5p induced by oncogenic KRAS is required for colorectal cancer progression.
Aspafilioside B induces G2/M cell cycle arrest and apoptosis by up-regulating H-Ras and N-Ras via ERK and p38 MAPK signaling pathways in human hepatoma HepG2 cells.
Microarray-based gene expression profiling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells.
Long non-coding RNA Malat1 promotes gallbladder cancer development by acting as a molecular sponge to regulate miR-206.
Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles.
Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells.
EGFR phosphorylates FAM129B to promote Ras activation.
SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status.
MiR-384 inhibits human colorectal cancer metastasis by targeting KRAS and CDC42.
Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease.
Expression of KRAS in the endometrium of early pregnant mice and its effect during embryo implantation.
Upregulation of let-7a inhibits vascular smooth muscle cell proliferation in vitro and in vein graft intimal hyperplasia in rats.
MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2.
Cryptosporidium parvum-induced ileo-caecal adenocarcinoma and Wnt signaling in a mouse model.
Anti-pancreatic cancer deliverables from sea: first-hand evidence on the efficacy, molecular targets and mode of action for multifarious polyphenols from five different brown-algae.
Investigation of elemene-induced reversal of tamoxifen resistance in MCF-7 cells through oestrogen receptor α (ERα) re-expression.
Let-7c functions as a metastasis suppressor by targeting MMP11 and PBX3 in colorectal cancer.
Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth.
Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer.
Sp1 expression regulates lung tumor progression.
Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.
Characterization of KRAS rearrangements in metastatic prostate cancer.
Zhao F, Yao Z, Li Y, Zhao W, Sun Y, Yang X, Zhao Z, Huang B, Wang J, Li X, Chen A
Cancer letters 2024 May 28;590:216844
Cancer letters 2024 May 28;590:216844
Carbene Footprinting Directs Design of Genetically Encoded Proximity-Reactive Protein Binders.
Ye H, Zhu Y, Kong Y, Wen H, Lu W, Wang D, Tang S, Zhan M, Lu G, Shao C, Wang N, Hao H
Analytical chemistry 2024 May 14;96(19):7566-7576
Analytical chemistry 2024 May 14;96(19):7566-7576
Classical prescription Floris Sophorae Powder treat colorectal cancer by regulating KRAS/MEK-ERK signaling pathway.
Han LY, Yu H, Wang S, Bao YR, Li TJ, Zheng Y, Luo X, Jia MN, Zhang Q, Meng XS
Journal of ethnopharmacology 2024 May 10;325:117805
Journal of ethnopharmacology 2024 May 10;325:117805
Reporter cell lines to screen for inhibitors or regulators of the KRAS-RAF-MEK1/2-ERK1/2 pathway.
Weatherdon L, Stuart K, Cassidy M, de la Gándara AM, Okkenhaug H, Muellener M, Mckenzie G, Cook SJ, Gilley R
The Biochemical journal 2024 Mar 20;481(6):405-422
The Biochemical journal 2024 Mar 20;481(6):405-422
TGFβ1-induced hedgehog signaling suppresses the immune response of brain microvascular endothelial cells elicited by meningitic Escherichia coli.
Sun J, Yang R, Fu J, Huo D, Qu X, Tan C, Chen H, Wang X
Cell communication and signaling : CCS 2024 Feb 15;22(1):123
Cell communication and signaling : CCS 2024 Feb 15;22(1):123
Cytoplasmic localization of SETDB1‑induced Warburg effect via c‑MYC‑LDHA axis enhances migration and invasion in breast carcinoma.
Yang W, Wei Y, Wang T, Xu Y, Jin X, Qian H, Yang S, He S
International journal of molecular medicine 2024 Apr;53(4)
International journal of molecular medicine 2024 Apr;53(4)
The CTLH Ubiquitin Ligase Substrates ZMYND19 and MKLN1 Negatively Regulate mTORC1 at the Lysosomal Membrane.
Wang Y, Guo R, Piedras BI, Tang HY, Asara JM, Tempera I, Lieberman PM, Gewurz BE
Research square 2024 Apr 24;
Research square 2024 Apr 24;
A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice.
Ma X, Yin J, Qiao L, Wan H, Liu X, Zhou Y, Wu J, Niu L, Wu M, Wang X, Ye H
Molecular cell 2024 Apr 18;84(8):1585-1600.e7
Molecular cell 2024 Apr 18;84(8):1585-1600.e7
Disruption of the pro-oncogenic c-RAF-PDE8A complex represents a differentiated approach to treating KRAS-c-RAF dependent PDAC.
Cooke SF, Wright TA, Sin YY, Ling J, Kyurkchieva E, Phanthaphol N, Mcskimming T, Herbert K, Rebus S, Biankin AV, Chang DK, Baillie GS, Blair CM
Scientific reports 2024 Apr 18;14(1):8998
Scientific reports 2024 Apr 18;14(1):8998
miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb the Proliferation and Functions of Chondrocytes.
Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z, Yang W, Yang H, Zhou Z
The American journal of pathology 2023 Sep;193(9):1234-1247
The American journal of pathology 2023 Sep;193(9):1234-1247
Spermine-Based Poly(β-amino ester)s for siRNA Delivery against Mutated KRAS in Lung Cancer.
Jin Y, Adams F, Isert L, Baldassi D, Merkel OM
Molecular pharmaceutics 2023 Sep 4;20(9):4505-4516
Molecular pharmaceutics 2023 Sep 4;20(9):4505-4516
Oncogenic BRAF noncanonically promotes tumor metastasis by mediating VASP phosphorylation and filopodia formation.
Pan W, Tian Y, Zheng Q, Yang Z, Qiang Y, Zhang Z, Zhang N, Xiong J, Zhu X, Wei L, Li F
Oncogene 2023 Oct;42(43):3194-3205
Oncogene 2023 Oct;42(43):3194-3205
Gold Nanoparticles Inhibit Macropinocytosis by Decreasing KRAS Activation.
Elechalawar CK, Rao G, Gulla SK, Patel MM, Frickenstein A, Means N, Roy RV, Tsiokas L, Asfa S, Panja P, Rao C, Wilhelm S, Bhattacharya R, Mukherjee P
ACS nano 2023 May 23;17(10):9326-9337
ACS nano 2023 May 23;17(10):9326-9337
An unconventional cancer-promoting function of methamphetamine in hepatocellular carcinoma.
Si Z, Yang G, Wang X, Yu Z, Pang Q, Zhang S, Qian L, Ruan Y, Huang J, Yu L
Life science alliance 2023 Mar;6(3)
Life science alliance 2023 Mar;6(3)
Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer.
Zhao C, Liu Z, Chang CC, Chen YC, Zhang Q, Zhang XD, Andreou C, Pang J, Liu ZX, Wang DY, Kircher MF, Yang J
ACS nano 2023 Mar 14;17(5):4261-4278
ACS nano 2023 Mar 14;17(5):4261-4278
LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL.
Ko A, Hasanain M, Oh YT, D'Angelo F, Sommer D, Frangaj B, Tran S, Bielle F, Pollo B, Paterra R, Mokhtari K, Soni RK, Peyre M, Eoli M, Papi L, Kalamarides M, Sanson M, Iavarone A, Lasorella A
Cancer discovery 2023 Mar 1;13(3):702-723
Cancer discovery 2023 Mar 1;13(3):702-723
HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis.
Jiang Q, Zhang D, Liu J, Liang C, Yang R, Zhang C, Wu J, Lin J, Ye T, Ding L, Li J, Gao S, Li B, Ye Q
Science advances 2023 Jun 9;9(23):eade1155
Science advances 2023 Jun 9;9(23):eade1155
RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
Ren JG, Xing B, Lv K, O'Keefe RA, Wu M, Wang R, Bauer KM, Ghazaryan A, Burslem GM, Zhang J, O'Connell RM, Pillai V, Hexner EO, Philips MR, Tong W
The Journal of clinical investigation 2023 Jun 15;133(12)
The Journal of clinical investigation 2023 Jun 15;133(12)
A TEAD2-Driven Endothelial-Like Program Shapes Basal-Like Differentiation and Metastasis of Pancreatic Cancer.
Yoo HB, Moon JW, Kim HR, Lee HS, Miyabayashi K, Park CH, Ge S, Zhang A, Tae YK, Sub Y, Park HW, Gee HY, Notta F, Tuveson DA, Bang S, Kim MY, Roe JS
Gastroenterology 2023 Jul;165(1):133-148.e17
Gastroenterology 2023 Jul;165(1):133-148.e17
Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells.
Qian F, Nettleford SK, Zhou J, Arner BE, Hall MA, Sharma A, Annageldiyev C, Rossi RM, Tukaramrao DB, Sarkar D, Hegde S, Gandhi UH, Finch ER, Goodfield L, Quickel MD, Claxton DF, Paulson RF, Prabhu KS
Cell reports 2023 Jul 25;42(7):112794
Cell reports 2023 Jul 25;42(7):112794
A First-Class Degrader Candidate Targeting Both KRAS G12D and G12V Mediated by CANDDY Technology Independent of Ubiquitination.
Miyamoto-Sato E, Imanishi S, Huang L, Itakura S, Iwasaki Y, Ishizaka M
Molecules (Basel, Switzerland) 2023 Jul 24;28(14)
Molecules (Basel, Switzerland) 2023 Jul 24;28(14)
The miR-143/145 cluster induced by TGF-β1 suppresses Wilms' tumor 1 expression in cultured human podocytes.
Tabei A, Sakairi T, Hamatani H, Ohishi Y, Watanabe M, Nakasatomi M, Ikeuchi H, Kaneko Y, Kopp JB, Hiromura K
American journal of physiology. Renal physiology 2023 Jul 1;325(1):F121-F133
American journal of physiology. Renal physiology 2023 Jul 1;325(1):F121-F133
Reversibility and developmental neuropathology of linear nevus sebaceous syndrome caused by dysregulation of the RAS pathway.
Kim YE, Kim YS, Lee HE, So KH, Choe Y, Suh BC, Kim JH, Park SK, Mathern GW, Gleeson JG, Rah JC, Baek ST
Cell reports 2023 Jan 31;42(1):112003
Cell reports 2023 Jan 31;42(1):112003
Association of KRAS, NRAS, BRAF and PIK3CA gene mutations with clinicopathological features, prognosis and ring finger protein 215 expression in patients with colorectal cancer.
Wu JB, Li XJ, Liu H, Liu YJ, Liu XP
Biomedical reports 2023 Dec;19(6):104
Biomedical reports 2023 Dec;19(6):104
Nutlin-3a induces KRAS mutant/p53 wild type lung cancer specific methuosis-like cell death that is dependent on GFPT2.
Kim D, Min D, Kim J, Kim MJ, Seo Y, Jung BH, Kwon SH, Ro H, Lee S, Sa JK, Lee JY
Journal of experimental & clinical cancer research : CR 2023 Dec 14;42(1):338
Journal of experimental & clinical cancer research : CR 2023 Dec 14;42(1):338
A proteomic signature and potential pharmacological opportunities in the adaptive resistance to MEK and PI3K kinase inhibition in pancreatic cancer cells.
Aguilar-Valdés A, González-Vela F, Sánchez-Vidal H, Martínez-Aguilar J
Proteomics 2023 Aug;23(16):e2300041
Proteomics 2023 Aug;23(16):e2300041
Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.
Pan Y, Gu Y, Liu T, Zhang Q, Yang F, Duan L, Cheng S, Zhu X, Xi Y, Chang X, Ye Q, Gao S
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120
Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival.
Danan CH, Naughton KE, Hayer KE, Vellappan S, McMillan EA, Zhou Y, Matsuda R, Nettleford SK, Katada K, Parham LR, Ma X, Chowdhury A, Wilkins BJ, Shah P, Weitzman MD, Hamilton KE
bioRxiv : the preprint server for biology 2023 Apr 21;
bioRxiv : the preprint server for biology 2023 Apr 21;
Promoted Skin Wound Healing by Tail-Amputated Eisenia foetida Proteins via the Ras/Raf/MEK/ERK Signaling Pathway.
Li T, Sun Y, Wang J, Zhang C, Sun Y
ACS omega 2023 Apr 18;8(15):13935-13943
ACS omega 2023 Apr 18;8(15):13935-13943
Ribitol alters multiple metabolic pathways of central carbon metabolism with enhanced glycolysis: A metabolomics and transcriptomics profiling of breast cancer.
Tucker JD, Doddapaneni R, Lu PJ, Lu QL
PloS one 2022;17(12):e0278711
PloS one 2022;17(12):e0278711
Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence.
Liu D, Lin S, Li Y, Zhou T, Hu K, Li Q
Drug design, development and therapy 2022;16:375-395
Drug design, development and therapy 2022;16:375-395
Natural product manoalide promotes EGFR-TKI sensitivity of lung cancer cells by KRAS-ERK pathway and mitochondrial Ca(2+) overload-induced ferroptosis.
Ni Y, Liu J, Zeng L, Yang Y, Liu L, Yao M, Chai L, Zhang L, Li Y, Zhang L, Li W
Frontiers in pharmacology 2022;13:1109822
Frontiers in pharmacology 2022;13:1109822
New mechanistic insights into the RAS-SIN1 interaction at the membrane.
Pudewell S, Lissy J, Nakhaeizadeh H, Mosaddeghzadeh N, Nakhaei-Rad S, Dvorsky R, Ahmadian MR
Frontiers in cell and developmental biology 2022;10:987754
Frontiers in cell and developmental biology 2022;10:987754
Mycoplasma gallisepticum induced exosomal gga-miR-193a to disturb cell proliferation, apoptosis, and cytokine production by targeting the KRAS/ERK signaling pathway.
Zou M, Fu Y, Zhao Y, Sun Y, Yin X, Peng X
International immunopharmacology 2022 Oct;111:109090
International immunopharmacology 2022 Oct;111:109090
Identification of MYEOV-Associated Gene Network as a Potential Therapeutic Target in Pancreatic Cancer.
Chen Y, Wang J, Guo Q, Li X, Zou X
Cancers 2022 Nov 4;14(21)
Cancers 2022 Nov 4;14(21)
Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.
Davies CW, Oh AJ, Mroue R, Steffek M, Bruning JM, Xiao Y, Feng S, Jayakar S, Chan E, Arumugam V, Uribe SC, Drummond J, Frommlet A, Lu C, Franke Y, Merchant M, Koeppen H, Quinn JG, Malhotra S, Do S, Gazzard L, Purkey HE, Rudolph J, Mulvihill MM, Koerber JT, Wang W, Evangelista M
Nature biotechnology 2022 May;40(5):769-778
Nature biotechnology 2022 May;40(5):769-778
Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway.
Zhang JJ, Cao CX, Wan LL, Zhang W, Liu ZJ, Wang JL, Guo Q, Tang H
World journal of gastroenterology 2022 May 7;28(17):1781-1797
World journal of gastroenterology 2022 May 7;28(17):1781-1797
Regulation of GTPase function by autophosphorylation.
Johnson CW, Seo HS, Terrell EM, Yang MH, KleinJan F, Gebregiworgis T, Gasmi-Seabrook GMC, Geffken EA, Lakhani J, Song K, Bashyal P, Popow O, Paulo JA, Liu A, Mattos C, Marshall CB, Ikura M, Morrison DK, Dhe-Paganon S, Haigis KM
Molecular cell 2022 Mar 3;82(5):950-968.e14
Molecular cell 2022 Mar 3;82(5):950-968.e14
Hyaluronic Acid-Modified Nanoparticles Self-Assembled from Linoleic Acid-Conjugated Chitosan for the Codelivery of miR34a and Doxorubicin in Resistant Breast Cancer.
Yang X, Shang P, Ji J, Malichewe C, Yao Z, Liao J, Du D, Sun C, Wang L, Tang YJ, Guo X
Molecular pharmaceutics 2022 Jan 3;19(1):2-17
Molecular pharmaceutics 2022 Jan 3;19(1):2-17
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone provokes progression from chronic pancreatitis to pancreatic intraepithelial neoplasia.
Chen X, Sheng L, Ma J, Qi D, Li X, Wang Z, Wu Z, Wong L, Huang JH, Wu E, Ma Q, Zhang D
iScience 2022 Jan 21;25(1):103647
iScience 2022 Jan 21;25(1):103647
Ionic Liquid-Based Extraction System for In-Depth Analysis of Membrane Protein Complexes.
Chu H, Zhao Q, Liu J, Yang K, Wang Y, Liu J, Zhang K, Zhao B, He H, Zheng Y, Zhong S, Liang Z, Zhang L, Zhang Y
Analytical chemistry 2022 Jan 18;94(2):758-767
Analytical chemistry 2022 Jan 18;94(2):758-767
PD-L1/PD-L1 signalling promotes colorectal cancer cell migration ability through RAS/MEK/ERK.
Cao Y, Liang W, Fang L, Liu MK, Zuo J, Peng YL, Shan JJ, Sun RX, Zhao J, Wang J
Clinical and experimental pharmacology & physiology 2022 Dec;49(12):1281-1293
Clinical and experimental pharmacology & physiology 2022 Dec;49(12):1281-1293
Redox-sensitive small GTPase H-Ras in murine astrocytes, an in vitro study.
Zuchegna C, Porcellini A, Messina S
Redox report : communications in free radical research 2022 Dec;27(1):150-157
Redox report : communications in free radical research 2022 Dec;27(1):150-157
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells.
Kurimchak AM, Herrera-Montávez C, Montserrat-Sangrà S, Araiza-Olivera D, Hu J, Neumann-Domer R, Kuruvilla M, Bellacosa A, Testa JR, Jin J, Duncan JS
Science signaling 2022 Aug 30;15(749):eabn2707
Science signaling 2022 Aug 30;15(749):eabn2707
Oncogenic Kras-Mediated Cytokine CCL15 Regulates Pancreatic Cancer Cell Migration and Invasion through ROS.
Messex JK, Adams KLA, Hawkins WG, DeNardo D, Bardeesy N, Billadeau DD, Liou GY
Cancers 2022 Apr 26;14(9)
Cancers 2022 Apr 26;14(9)
LncRNA IGFL2-AS1 Promotes the Proliferation, Migration, and Invasion of Colon Cancer Cells and is Associated with Patient Prognosis.
Cen X, Huang Y, Lu Z, Shao W, Zhuo C, Bao C, Feng S, Wei C, Tang X, Cen L, Guo W, Tian X, Tang Q, Huang X
Cancer management and research 2021;13:5957-5968
Cancer management and research 2021;13:5957-5968
JMJD8 Promotes Malignant Progression of Lung Cancer by Maintaining EGFR Stability and EGFR/PI3K/AKT Pathway Activation.
Zhang B, Zhang Y, Jiang X, Su H, Wang Q, Wudu M, Jiang J, Ren H, Xu Y, Liu Z, Qiu X
Journal of Cancer 2021;12(4):976-987
Journal of Cancer 2021;12(4):976-987
Hsa-miR-557 Inhibits Osteosarcoma Growth Through Targeting KRAS.
Qiao Z, Li J, Kou H, Chen X, Bao D, Shang G, Chen S, Ji Y, Cheng T, Wang Y, Liu H
Frontiers in genetics 2021;12:789823
Frontiers in genetics 2021;12:789823
YRDC Mediates the Resistance of Lenvatinib in Hepatocarcinoma Cells via Modulating the Translation of KRAS.
Guo J, Zhu P, Ye Z, Wang M, Yang H, Huang S, Shu Y, Zhang W, Zhou H, Li Q
Frontiers in pharmacology 2021;12:744578
Frontiers in pharmacology 2021;12:744578
Discovery of a New CDK4/6 and PI3K/AKT Multiple Kinase Inhibitor Aminoquinol for the Treatment of Hepatocellular Carcinoma.
Xia ZK, Wang W, Qiu JG, Shi XN, Li HJ, Chen R, Ke KB, Dong C, Zhu Y, Wu SG, Zhang RP, Meng ZR, Zhao H, Gu P, Leung KS, Wong MH, Liu XD, Zhou FM, Zhang JY, Yao YT, Wang SJ, Zhang CY, Qin YR, Lin MC, Jiang BH
Frontiers in pharmacology 2021;12:691769
Frontiers in pharmacology 2021;12:691769
Identification and Confirmation of the miR-30 Family as a Potential Central Player in Tobacco-Related Head and Neck Squamous Cell Carcinoma.
Zhang T, Zhu X, Sun Q, Qin X, Zhang Z, Feng Y, Yan M, Chen W
Frontiers in oncology 2021;11:616372
Frontiers in oncology 2021;11:616372
Quadruple-editing of the MAPK and PI3K pathways effectively blocks the progression of KRAS-mutated colorectal cancer cells.
Wang Z, Kang B, Gao Q, Huang L, Di J, Fan Y, Yu J, Jiang B, Gao F, Wang D, Sun H, Gu Y, Li J, Su X
Cancer science 2021 Sep;112(9):3895-3910
Cancer science 2021 Sep;112(9):3895-3910
PFP@PLGA/Cu(12)Sb(4)S(13)-mediated PTT ablates hepatocellular carcinoma by inhibiting the RAS/MAPK/MT-CO1 signaling pathway.
Dong T, Jiang J, Zhang H, Liu H, Zou X, Niu J, Mao Y, Zhu M, Chen X, Li Z, Chen Y, Shi C, Yang X
Nano convergence 2021 Oct 4;8(1):29
Nano convergence 2021 Oct 4;8(1):29
The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation.
Sun L, Wang W, Han C, Huang W, Sun Y, Fang K, Zeng Z, Yang Q, Pan Q, Chen T, Luo X, Chen Y
Molecular cell 2021 Nov 4;81(21):4493-4508.e9
Molecular cell 2021 Nov 4;81(21):4493-4508.e9
In vivo self-assembled small RNAs as a new generation of RNAi therapeutics.
Fu Z, Zhang X, Zhou X, Ur-Rehman U, Yu M, Liang H, Guo H, Guo X, Kong Y, Su Y, Ye Y, Hu X, Cheng W, Wu J, Wang Y, Gu Y, Lu SF, Wu D, Zen K, Li J, Yan C, Zhang CY, Chen X
Cell research 2021 Jun;31(6):631-648
Cell research 2021 Jun;31(6):631-648
A novel circular RNA, circPUS7 promotes cadmium-induced transformation of human bronchial epithelial cells by regulating Kirsten rat sarcoma viral oncogene homolog expression via sponging miR-770.
Pan S, Wang Q, Zhang Q, Zhou M, Li L, Zhou X
Metallomics : integrated biometal science 2021 Jul 24;13(7)
Metallomics : integrated biometal science 2021 Jul 24;13(7)
Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling.
Liu C, Lu H, Wang H, Loo A, Zhang X, Yang G, Kowal C, Delach S, Wang Y, Goldoni S, Hastings WD, Wong K, Gao H, Meyer MJ, Moody SE, LaMarche MJ, Engelman JA, Williams JA, Hammerman PS, Abrams TJ, Mohseni M, Caponigro G, Hao HX
Clinical cancer research : an official journal of the American Association for Cancer Research 2021 Jan 1;27(1):342-354
Clinical cancer research : an official journal of the American Association for Cancer Research 2021 Jan 1;27(1):342-354
CEP164 Deficiency Causes Hyperproliferation of Pancreatic Cancer Cells.
Kobayashi T, Tanaka K, Mashima Y, Shoda A, Tokuda M, Itoh H
Frontiers in cell and developmental biology 2020;8:587691
Frontiers in cell and developmental biology 2020;8:587691
Comparison of anticarcinogenic properties of Viburnum opulus and its active compound p-coumaric acid on human colorectal carcinoma.
Karakurt S, AbuŞoĞlu G, Arituluk ZC
Turkish journal of biology = Turk biyoloji dergisi 2020;44(5):252-263
Turkish journal of biology = Turk biyoloji dergisi 2020;44(5):252-263
Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics.
Shangguan F, Liu Y, Ma L, Qu G, Lv Q, An J, Yang S, Lu B, Cao Q
Journal of Cancer 2020;11(12):3454-3466
Journal of Cancer 2020;11(12):3454-3466
Precise and efficient silencing of mutant Kras(G12D) by CRISPR-CasRx controls pancreatic cancer progression.
Jiang W, Li H, Liu X, Zhang J, Zhang W, Li T, Liu L, Yu X
Theranostics 2020;10(25):11507-11519
Theranostics 2020;10(25):11507-11519
Ubiquitin-binding associated protein 2 regulates KRAS activation and macropinocytosis in pancreatic cancer.
Xiong X, Rao G, Roy RV, Zhang Y, Means N, Dey A, Tsaliki M, Saha S, Bhattacharyya S, Dhar Dwivedi SK, Rao CV, McCormick DJ, Dhanasekaran D, Ding K, Gillies E, Zhang M, Yang D, Bhattacharya R, Mukherjee P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Sep;34(9):12024-12039
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Sep;34(9):12024-12039
Siah2 integrates mitogenic and extracellular matrix signals linking neuronal progenitor ciliogenesis with germinal zone occupancy.
Ong T, Trivedi N, Wakefield R, Frase S, Solecki DJ
Nature communications 2020 Oct 20;11(1):5312
Nature communications 2020 Oct 20;11(1):5312
Establishment and Characterization of Immortalized Miniature Pig Pancreatic Cell Lines Expressing Oncogenic K-Ras(G12D).
Yang HJ, Song BS, Sim BW, Jung Y, Chae U, Lee DG, Cha JJ, Baek SJ, Lim KS, Choi WS, Lee HY, Son HC, Park SH, Jeong KJ, Kang P, Baek SH, Koo BS, Kim HN, Jin YB, Park YH, Choo YK, Kim SU
International journal of molecular sciences 2020 Nov 21;21(22)
International journal of molecular sciences 2020 Nov 21;21(22)
Discovery of Turn-On Fluorescent Probes for Detecting PDEδ Protein in Living Cells and Tumor Slices.
Dong G, Chen L, Zhang J, Liu T, Du L, Sheng C, Li M
Analytical chemistry 2020 Jul 21;92(14):9516-9522
Analytical chemistry 2020 Jul 21;92(14):9516-9522
Immunohistochemical assessment of growth factor signaling molecules: MAPK, Akt, and STAT3 pathways in oral epithelial precursor lesions and squamous cell carcinoma.
Tashiro K, Oikawa M, Miki Y, Takahashi T, Kumamoto H
Odontology 2020 Jan;108(1):91-101
Odontology 2020 Jan;108(1):91-101
VPS33B negatively modulated by nicotine functions as a tumor suppressor in colorectal cancer.
Chen Y, Liu Z, Wang H, Tang Z, Liu Y, Liang Z, Deng X, Zhao M, Fu Q, Li L, Cai H, Xie W, Fang W
International journal of cancer 2020 Jan 15;146(2):496-509
International journal of cancer 2020 Jan 15;146(2):496-509
Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions.
Zhang Y, Meng X, Tang H, Cheng M, Yang F, Xu W
Journal of enzyme inhibition and medicinal chemistry 2020 Dec;35(1):344-353
Journal of enzyme inhibition and medicinal chemistry 2020 Dec;35(1):344-353
Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening.
Du Y, Li X, Niu Q, Mo X, Qui M, Ma T, Kuo CJ, Fu H
Journal of molecular cell biology 2020 Aug 1;12(8):630-643
Journal of molecular cell biology 2020 Aug 1;12(8):630-643
Ribosome profiling analysis identified a KRAS-interacting microprotein that represses oncogenic signaling in hepatocellular carcinoma cells.
Xu W, Deng B, Lin P, Liu C, Li B, Huang Q, Zhou H, Yang J, Qu L
Science China. Life sciences 2020 Apr;63(4):529-542
Science China. Life sciences 2020 Apr;63(4):529-542
DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas.
Yang MQ, Bai LL, Lei L, Zheng YW, Wang Z, Li ZH, Liu CC, Huang WJ, Xu HT
Oncology reports 2020 Apr;43(4):1338-1348
Oncology reports 2020 Apr;43(4):1338-1348
Cell-type specific tumorigenesis with Ras oncogenes in human lung epithelial cells.
Kumazaki M, Shimomura I, Kiyono T, Ochiya T, Yamamoto Y
Biochemical and biophysical research communications 2020 Apr 30;525(2):483-490
Biochemical and biophysical research communications 2020 Apr 30;525(2):483-490
RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer.
Zhang X, Ma N, Yao W, Li S, Ren Z
Cancer cell international 2019;19:356
Cancer cell international 2019;19:356
UBN2 promotes tumor progression via the Ras/MAPK pathway and predicts poor prognosis in colorectal cancer.
Zhao YL, Zhong SR, Zhang SH, Bi JX, Xiao ZY, Wang SY, Jiao HL, Zhang D, Qiu JF, Zhang LJ, Huang CM, Chen XL, Ding YQ, Ye YP, Liang L, Liao WT
Cancer cell international 2019;19:126
Cancer cell international 2019;19:126
Apigenin Combined With Gefitinib Blocks Autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells.
Chen Z, Tian D, Liao X, Zhang Y, Xiao J, Chen W, Liu Q, Chen Y, Li D, Zhu L, Cai S
Frontiers in pharmacology 2019;10:260
Frontiers in pharmacology 2019;10:260
ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer.
Zhao H, Wu S, Li H, Duan Q, Zhang Z, Shen Q, Wang C, Yin T
Molecular therapy oncolytics 2019 Sep 27;14:299-312
Molecular therapy oncolytics 2019 Sep 27;14:299-312
Characterization of Protein Profiling and mRNA Expression of LLC Exosomes.
Zhang W, He P, Wang S, Adili A, Chen Z, Zhang CY, Jiang X, Li J, Zhang Y
The protein journal 2019 Oct;38(5):586-597
The protein journal 2019 Oct;38(5):586-597
The development of a cell-based model for the assessment of carcinogenic potential upon long-term PM2.5 exposure.
Chen S, Li D, Zhang H, Yu D, Chen R, Zhang B, Tan Y, Niu Y, Duan H, Mai B, Chen S, Yu J, Luan T, Chen L, Xing X, Li Q, Xiao Y, Dong G, Niu Y, Aschner M, Zhang R, Zheng Y, Chen W
Environment international 2019 Oct;131:104943
Environment international 2019 Oct;131:104943
MEK nuclear localization promotes YAP stability via sequestering β-TrCP in KRAS mutant cancer cells.
Xu H, Zhou S, Xia H, Yu H, Tang Q, Bi F
Cell death and differentiation 2019 Nov;26(11):2400-2415
Cell death and differentiation 2019 Nov;26(11):2400-2415
Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors.
Sale MJ, Minihane E, Monks NR, Gilley R, Richards FM, Schifferli KP, Andersen CL, Davies EJ, Vicente MA, Ozono E, Markovets A, Dry JR, Drew L, Flemington V, Proia T, Jodrell DI, Smith PD, Cook SJ
Nature communications 2019 Nov 14;10(1):5167
Nature communications 2019 Nov 14;10(1):5167
KRAS regulation by small non-coding RNAs and SNARE proteins.
Che Y, Siprashvili Z, Kovalski JR, Jiang T, Wozniak G, Elcavage L, Khavari PA
Nature communications 2019 Nov 11;10(1):5118
Nature communications 2019 Nov 11;10(1):5118
Effectiveness of a genetic test panel designed for gynecological cancer: an exploratory study.
Ida K, Miyamoto T, Higuchi S, Takeuchi H, Yamada S, Ono M, Nishihara H, Shiozawa T
Medical oncology (Northwood, London, England) 2019 May 29;36(7):62
Medical oncology (Northwood, London, England) 2019 May 29;36(7):62
Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer.
Adams CR, Htwe HH, Marsh T, Wang AL, Montoya ML, Subbaraj L, Tward AD, Bardeesy N, Perera RM
eLife 2019 May 28;8
eLife 2019 May 28;8
HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform to Reveal IAP Antagonists as Anti-cancer Immune Enhancers.
Mo X, Tang C, Niu Q, Ma T, Du Y, Fu H
Cell chemical biology 2019 Mar 21;26(3):331-339.e3
Cell chemical biology 2019 Mar 21;26(3):331-339.e3
Long noncoding RNA PCAT1, a novel serum-based biomarker, enhances cell growth by sponging miR-326 in oesophageal squamous cell carcinoma.
Huang L, Wang Y, Chen J, Wang Y, Zhao Y, Wang Y, Ma Y, Chen X, Liu W, Li Z, Zhao L, Shan B, Dong X, Li D, Shao S, Song Y, Zhan Q, Liu X
Cell death & disease 2019 Jul 4;10(7):513
Cell death & disease 2019 Jul 4;10(7):513
Zoledronic acid enhances the efficacy of the MEK inhibitor trametinib in KRAS mutant cancers.
Dai X, Xia H, Zhou S, Tang Q, Bi F
Cancer letters 2019 Feb 1;442:202-212
Cancer letters 2019 Feb 1;442:202-212
Final-2 targeted glycolysis mediated apoptosis and autophagy in human lung adenocarcinoma cells but failed to inhibit xenograft in nude mice.
Chen Z, Yang D, Jiang X, Tian L, Sun J, Tian D, Bai W
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2019 Aug;130:1-11
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2019 Aug;130:1-11
SHIP1 inhibits cell growth, migration, and invasion in non‑small cell lung cancer through the PI3K/AKT pathway.
Fu Q, Huang Y, Ge C, Li Z, Tian H, Li Q, Li H, Li R, Tao X, Xue Y, Wang Y, Yang G, Fang W, Song X
Oncology reports 2019 Apr;41(4):2337-2350
Oncology reports 2019 Apr;41(4):2337-2350
Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition.
Gao L, Hu Y, Tian Y, Fan Z, Wang K, Li H, Zhou Q, Zeng G, Hu X, Yu L, Zhou S, Tong X, Huang H, Chen H, Liu Q, Liu W, Zhang G, Zeng M, Zhou G, He Q, Ji H, Chen L
Nature communications 2019 Apr 10;10(1):1665
Nature communications 2019 Apr 10;10(1):1665
Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells.
Gao P, Wang X, Jin Y, Hu W, Duan Y, Shi A, Du Y, Song D, Yang M, Li S, Han B, Zhao G, Zhang H, Fan Z, Miao QR
Breast cancer research : BCR 2018 Sep 12;20(1):112
Breast cancer research : BCR 2018 Sep 12;20(1):112
Genome-wide transcriptional analysis of BRD4-regulated genes and pathways in human glioma U251 cells.
Du Z, Song X, Yan F, Wang J, Zhao Y, Liu S
International journal of oncology 2018 May;52(5):1415-1426
International journal of oncology 2018 May;52(5):1415-1426
Impairment of K-Ras signaling networks and increased efficacy of epidermal growth factor receptor inhibitors by a novel synthetic miR-143.
Akao Y, Kumazaki M, Shinohara H, Sugito N, Kuranaga Y, Tsujino T, Yoshikawa Y, Kitade Y
Cancer science 2018 May;109(5):1455-1467
Cancer science 2018 May;109(5):1455-1467
Mutant KRAS promotes liver metastasis of colorectal cancer, in part, by upregulating the MEK-Sp1-DNMT1-miR-137-YB-1-IGF-IR signaling pathway.
Chu PC, Lin PC, Wu HY, Lin KT, Wu C, Bekaii-Saab T, Lin YJ, Lee CT, Lee JC, Chen CS
Oncogene 2018 Jun;37(25):3440-3455
Oncogene 2018 Jun;37(25):3440-3455
Overexpression of miR-19a inhibits colorectal cancer angiogenesis by suppressing KRAS expression.
Chen M, Lin M, Wang X
Oncology reports 2018 Feb;39(2):619-626
Oncology reports 2018 Feb;39(2):619-626
Nogo-B receptor promotes epithelial-mesenchymal transition in non-small cell lung cancer cells through the Ras/ERK/Snail1 pathway.
Wu D, Zhao B, Qi X, Peng F, Fu H, Chi X, Miao QR, Shao S
Cancer letters 2018 Apr 1;418:135-146
Cancer letters 2018 Apr 1;418:135-146
Lin28B facilitates the progression and metastasis of pancreatic ductal adenocarcinoma.
Wang Y, Li J, Guo S, Ouyang Y, Yin L, Liu S, Zhao Z, Yang J, Huang W, Qin H, Zhao X, Ni B, Wang H
Oncotarget 2017 Sep 1;8(36):60414-60428
Oncotarget 2017 Sep 1;8(36):60414-60428
The transcription factor HOXB7 regulates ERK kinase activity and thereby stimulates the motility and invasiveness of pancreatic cancer cells.
Tsuboi M, Taniuchi K, Shimizu T, Saito M, Saibara T
The Journal of biological chemistry 2017 Oct 27;292(43):17681-17702
The Journal of biological chemistry 2017 Oct 27;292(43):17681-17702
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
Liu W, Zhang B, Hu Q, Qin Y, Xu W, Shi S, Liang C, Meng Q, Xiang J, Liang D, Ji S, Liu J, Hu P, Liu L, Liu C, Long J, Ni Q, Yu X, Xu J
International journal of oncology 2017 May;50(5):1792-1800
International journal of oncology 2017 May;50(5):1792-1800
ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
Liang C, Qin Y, Zhang B, Ji S, Shi S, Xu W, Liu J, Xiang J, Liang D, Hu Q, Ni Q, Yu X, Xu J
Cancer letters 2017 Mar 1;388:303-311
Cancer letters 2017 Mar 1;388:303-311
Low-Dose Farnesyltransferase Inhibitor Suppresses HIF-1α and Snail Expression in Triple-Negative Breast Cancer MDA-MB-231 Cells In Vitro.
Tanaka T, Ikegami Y, Nakazawa H, Kuriyama N, Oki M, Hanai J, Sukhatme VP, Kaneki M
Journal of cellular physiology 2017 Jan;232(1):192-201
Journal of cellular physiology 2017 Jan;232(1):192-201
HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma.
Kobayashi T, Nakazono K, Tokuda M, Mashima Y, Dynlacht BD, Itoh H
EMBO reports 2017 Feb;18(2):334-343
EMBO reports 2017 Feb;18(2):334-343
Oncogenic KRAS Targets MUC16/CA125 in Pancreatic Ductal Adenocarcinoma.
Liang C, Qin Y, Zhang B, Ji S, Shi S, Xu W, Liu J, Xiang J, Liang D, Hu Q, Ni Q, Xu J, Yu X
Molecular cancer research : MCR 2017 Feb;15(2):201-212
Molecular cancer research : MCR 2017 Feb;15(2):201-212
Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways.
Huang YJ, Yang CK, Wei PL, Huynh TT, Whang-Peng J, Meng TC, Hsiao M, Tzeng YM, Wu AT, Yen Y
Journal of hematology & oncology 2017 Feb 28;10(1):60
Journal of hematology & oncology 2017 Feb 28;10(1):60
miR-450b-5p induced by oncogenic KRAS is required for colorectal cancer progression.
Ye YP, Wu P, Gu CC, Deng DL, Jiao HL, Li TT, Wang SY, Wang YX, Xiao ZY, Wei WT, Chen YR, Qiu JF, Yang RW, Lin J, Liang L, Liao WT, Ding YQ
Oncotarget 2016 Sep 20;7(38):61312-61324
Oncotarget 2016 Sep 20;7(38):61312-61324
Aspafilioside B induces G2/M cell cycle arrest and apoptosis by up-regulating H-Ras and N-Ras via ERK and p38 MAPK signaling pathways in human hepatoma HepG2 cells.
Liu W, Ning R, Chen RN, Huang XF, Dai QS, Hu JH, Wang YW, Wu LL, Xiong J, Hu G, Guo QL, Yang J, Wang H
Molecular carcinogenesis 2016 May;55(5):440-57
Molecular carcinogenesis 2016 May;55(5):440-57
Microarray-based gene expression profiling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells.
Xu Q, Fu R, Yin G, Liu X, Liu Y, Xiang M
Gene 2016 Mar 10;578(2):263-73
Gene 2016 Mar 10;578(2):263-73
Long non-coding RNA Malat1 promotes gallbladder cancer development by acting as a molecular sponge to regulate miR-206.
Wang SH, Zhang WJ, Wu XC, Zhang MD, Weng MZ, Zhou D, Wang JD, Quan ZW
Oncotarget 2016 Jun 21;7(25):37857-37867
Oncotarget 2016 Jun 21;7(25):37857-37867
Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles.
Kim E, Ilic N, Shrestha Y, Zou L, Kamburov A, Zhu C, Yang X, Lubonja R, Tran N, Nguyen C, Lawrence MS, Piccioni F, Bagul M, Doench JG, Chouinard CR, Wu X, Hogstrom L, Natoli T, Tamayo P, Horn H, Corsello SM, Lage K, Root DE, Subramanian A, Golub TR, Getz G, Boehm JS, Hahn WC
Cancer discovery 2016 Jul;6(7):714-26
Cancer discovery 2016 Jul;6(7):714-26
Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells.
Chu PC, Yang MC, Kulp SK, Salunke SB, Himmel LE, Fang CS, Jadhav AM, Shan YS, Lee CT, Lai MD, Shirley LA, Bekaii-Saab T, Chen CS
Oncogene 2016 Jul 28;35(30):3897-908
Oncogene 2016 Jul 28;35(30):3897-908
EGFR phosphorylates FAM129B to promote Ras activation.
Ji H, Lee JH, Wang Y, Pang Y, Zhang T, Xia Y, Zhong L, Lyu J, Lu Z
Proceedings of the National Academy of Sciences of the United States of America 2016 Jan 19;113(3):644-9
Proceedings of the National Academy of Sciences of the United States of America 2016 Jan 19;113(3):644-9
SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status.
Song HY, Biancucci M, Kang HJ, O'Callaghan C, Park SH, Principe DR, Jiang H, Yan Y, Satchell KF, Raparia K, Gius D, Vassilopoulos A
Oncotarget 2016 Dec 6;7(49):80336-80349
Oncotarget 2016 Dec 6;7(49):80336-80349
MiR-384 inhibits human colorectal cancer metastasis by targeting KRAS and CDC42.
Wang YX, Chen YR, Liu SS, Ye YP, Jiao HL, Wang SY, Xiao ZY, Wei WT, Qiu JF, Liang L, Liao WT, Ding YQ
Oncotarget 2016 Dec 20;7(51):84826-84838
Oncotarget 2016 Dec 20;7(51):84826-84838
Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease.
Ramraj SK, Aravindan S, Somasundaram DB, Herman TS, Natarajan M, Aravindan N
Oncotarget 2016 Apr 5;7(14):18605-19
Oncotarget 2016 Apr 5;7(14):18605-19
Expression of KRAS in the endometrium of early pregnant mice and its effect during embryo implantation.
Long X, Zhang M, Chen X, He J, Ding Y, Zhang C, Liu X, Wang Y
Reproductive biomedicine online 2015 Jul;31(1):51-61
Reproductive biomedicine online 2015 Jul;31(1):51-61
Upregulation of let-7a inhibits vascular smooth muscle cell proliferation in vitro and in vein graft intimal hyperplasia in rats.
Cao H, Hu X, Zhang Q, Wang J, Li J, Liu B, Shao Y, Li X, Zhang J, Xin S
The Journal of surgical research 2014 Nov;192(1):223-33
The Journal of surgical research 2014 Nov;192(1):223-33
MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2.
Liao WT, Ye YP, Zhang NJ, Li TT, Wang SY, Cui YM, Qi L, Wu P, Jiao HL, Xie YJ, Zhang C, Wang JX, Ding YQ
The Journal of pathology 2014 Mar;232(4):415-27
The Journal of pathology 2014 Mar;232(4):415-27
Cryptosporidium parvum-induced ileo-caecal adenocarcinoma and Wnt signaling in a mouse model.
Benamrouz S, Conseil V, Chabé M, Praet M, Audebert C, Blervaque R, Guyot K, Gazzola S, Mouray A, Chassat T, Delaire B, Goetinck N, Gantois N, Osman M, Slomianny C, Dehennaut V, Lefebvre T, Viscogliosi E, Cuvelier C, Dei-Cas E, Creusy C, Certad G
Disease models & mechanisms 2014 Jun;7(6):693-700
Disease models & mechanisms 2014 Jun;7(6):693-700
Anti-pancreatic cancer deliverables from sea: first-hand evidence on the efficacy, molecular targets and mode of action for multifarious polyphenols from five different brown-algae.
Aravindan S, Delma CR, Thirugnanasambandan SS, Herman TS, Aravindan N
PloS one 2013;8(4):e61977
PloS one 2013;8(4):e61977
Investigation of elemene-induced reversal of tamoxifen resistance in MCF-7 cells through oestrogen receptor α (ERα) re-expression.
Zhang B, Zhang X, Tang B, Zheng P, Zhang Y
Breast cancer research and treatment 2012 Nov;136(2):399-406
Breast cancer research and treatment 2012 Nov;136(2):399-406
Let-7c functions as a metastasis suppressor by targeting MMP11 and PBX3 in colorectal cancer.
Han HB, Gu J, Zuo HJ, Chen ZG, Zhao W, Li M, Ji DB, Lu YY, Zhang ZQ
The Journal of pathology 2012 Feb;226(3):544-55
The Journal of pathology 2012 Feb;226(3):544-55
Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth.
Hsu TI, Wang MC, Chen SY, Huang ST, Yeh YM, Su WC, Chang WC, Hung JJ
Molecular pharmacology 2012 Dec;82(6):1115-28
Molecular pharmacology 2012 Dec;82(6):1115-28
Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer.
Laheru D, Shah P, Rajeshkumar NV, McAllister F, Taylor G, Goldsweig H, Le DT, Donehower R, Jimeno A, Linden S, Zhao M, Song D, Rudek MA, Hidalgo M
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 12063-1-AP(KRAS antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-KRAS (IP:12063-1-AP, 3ug; Detection:12063-1-AP 1:1000) with HeLa cells lysate 2500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 12063-1-AP(KRAS antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The KRAS antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human KRAS. This antibody recognizes human,mouse,rat antigen. The KRAS antibody has been validated for the following applications: ELISA, WB, IHC, IP, FC analysis.
