AGTO-G041D

antibody from Creative Biolabs

Targeting: IL15RA CD215, IL-15RA

No application information provided.

Antibody Data

Product number

AGTO-G041D

Provider

Creative Biolabs

Product name

IL-15-DT immunotoxin

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the IL-15 to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to interleukin-15 receptor (IL-15R)-overexpressing cells and the toxin enters cells by receptor-mediated endocytosis. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death. It was designed for treatment of arthritis.

Reactivity

Human

Host

Rat