330207

antibody from BioLegend

Targeting: IL15RA CD215, IL-15RA

Antibody data

Submit

Validation data

Product number: 330207 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#330207, RRID:AB_2124602
Product name: PE anti-human CD215 (IL-15R)
Antibody type: Monoclonal
Antigen: IL-15Ra
Description: IL-15 receptor α (IL-15Rα) is a cytokine receptor with the structural homology to IL-2Rα (CD25). Both α receptors contain a group of β sandwich protein called sushi domains. Similar to IL-2Rα, IL-15Rα is able to form heterotrimer with their β chain (CD122) and common γ chain (γc, CD132). But unlike IL-2Rα subunit, IL-15Rα itself binds to IL-15 with equivalent high affinity comparing with the heterotimeric complex. IL-15Rα is expressed as soluble or transmembrane forms by variety cells, such as activated monocytes, dendrtic cells, CD8+ memory T cells, NK or NKT cells. IL-15Rα by itself forms stable complexes with IL-15 on cell surface and presents IL-15 in trans to neighboring cells. IL-15, like IL-2, is a pleiotropic four-helix bundle cytokine and plays a key role in promoting T and B cell survival and proliferation, preferentially in memory CD8+ T cell proliferation, and NK/NKT cell development.
Reactivity: Human
Host: Mouse
Conjugate: Yellow dye
Isotype: IgG
Vial size: 25 tests
Storage: The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

IL15RA protein structure - 330207 shown in red.