Antibody data
- Antibody Data
- Antigen structure
- References [59]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
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- Product number
- 19937-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19937-1-AP, RRID:AB_10646444
- Product name
- CYP2E1-Specific antibody
- Antibody type
- Polyclonal
- Description
- CYP2E1-Specific antibody (Cat. #19937-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Effect of fucoidan on ethanol-induced liver injury and steatosis in mice and the underlying mechanism.
TA allele of rs2070673 in the CYP2E1 gene is associated with lobular inflammation and nonalcoholic steatohepatitis in patients with biopsy-proven nonalcoholic fatty liver disease.
Compromised glutathione synthesis results in high susceptibility to acetaminophen hepatotoxicity in acatalasemic mice.
Hepatoprotective effects of ginsenoside Rk3 in acetaminophen-induced liver injury in mice by activation of autophagy.
MicroRNA-29b ameliorates hepatic inflammation via suppression of STAT3 in alcohol-associated liver disease.
Tryptophan Pathway-Targeted Metabolomics Study on the Mechanism and Intervention of Cisplatin-Induced Acute Kidney Injury in Rats.
Allicin alleviated acrylamide-induced NLRP3 inflammasome activation via oxidative stress and endoplasmic reticulum stress in Kupffer cells and SD rats liver.
Triptolide regulates oxidative stress and inflammation leading to hepatotoxicity via inducing CYP2E1.
Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury.
Gut microbiota accelerates cisplatin-induced acute liver injury associated with robust inflammation and oxidative stress in mice.
Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis.
circ-CBFB upregulates p66Shc to perturb mitochondrial dynamics in APAP-induced liver injury.
Intrabody against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver injury in mice via concomitant promotion of angiogenesis and redox homeostasis.
Intestinal Epithelial Chemokine (C-C Motif) Ligand 7 Overexpression Enhances Acetaminophen-Induced Hepatotoxicity in Mice.
Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure.
Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways.
Knockdown of Long Noncoding RNAs Hepatocyte Nuclear Factor 1α Antisense RNA 1 and Hepatocyte Nuclear Factor 4α Antisense RNA 1 Alters Susceptibility of Acetaminophen-Induced Cytotoxicity in HepaRG Cells.
Chronic intake of high-dose of blueberry leaf extract does not augment the harmful effects of ethanol in rats.
Inhibitory Effect of Corilagin on miR-21-Regulated Hepatic Fibrosis Signaling Pathway.
CCl4-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway.
Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae.
Neuroprotective Effect of Dioscin on the Aging Brain.
Inhibition of the mitochondrial complex-1 protects against carbon tetrachloride-induced acute liver injury.
Benzene-induced mouse hematotoxicity is regulated by a protein phosphatase 2A complex that stimulates transcription of cytochrome P4502E1.
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Protective effects of ginsenoside Rk3 against chronic alcohol-induced liver injury in mice through inhibition of inflammation, oxidative stress, and apoptosis.
Hepatoprotective Potential of Partially Hydrolyzed Guar Gum against Acute Alcohol-Induced Liver Injury in Vitro and Vivo.
Study on the potential way of hepatic cytotoxicity of N,N-dimethylformamide.
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Neurotoxicity, behavioral changes and gene-expression profile of mice exposed to SnS2 nanoflowers.
Schisantherin A alleviated alcohol-induced liver injury by the regulation of alcohol metabolism and NF-kB pathway.
Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury.
Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity.
Salvianolic acid A alleviates chronic ethanol-induced liver injury via promotion of β-catenin nuclear accumulation by restoring SIRT1 in rats.
Decreased expression of hepatic cytochrome P450 1A2 (CYP1A2) in a chronic intermittent hypoxia mouse model.
Hepatoprotective Effect of Polyphenol-Enriched Fraction from Folium Microcos on Oxidative Stress and Apoptosis in Acetaminophen-Induced Liver Injury in Mice.
Glycyrrhetinic acid prevents acetaminophen-induced acute liver injury via the inhibition of CYP2E1 expression and HMGB1-TLR4 signal activation in mice.
Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression.
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Chronic Acrylamide Exposure in Male Mice Results in Elevated DNA Damage in the Germline and Heritable Induction of CYP2E1 in the Testes.
Chronic plus binge ethanol exposure causes more severe pancreatic injury and inflammation.
Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress.
Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat.
Alteration in the expression of cytochrome P450s (CYP1A1, CYP2E1, and CYP3A11) in the liver of mouse induced by microcystin-LR.
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Potent effects of dioscin against obesity in mice.
Potent effects of dioscin against liver fibrosis.
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK/NF-κB pathway.
Protective effects of dioscin against alcohol-induced liver injury.
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Human placental lactogen induces CYP2E1 expression via PI 3-kinase pathway in female human hepatocytes.
Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation.
Protective effects of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.
Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats.
Protection of cyanidin-3-glucoside against oxidative stress induced by acrylamide in human MDA-MB-231 cells.
Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.
Protective effect of L-theanine on carbon tetrachloride-induced acute liver injury in mice.
Xue M, Liang H, Zhou Z, Liu Y, He X, Zhang Z, Sun T, Yang J, Qin Y, Qin K
Food & nutrition research 2021;65
Food & nutrition research 2021;65
TA allele of rs2070673 in the CYP2E1 gene is associated with lobular inflammation and nonalcoholic steatohepatitis in patients with biopsy-proven nonalcoholic fatty liver disease.
Ma HL, Chen SD, Zheng KI, Yu Y, Wang XX, Tang LJ, Li G, Rios RS, Huang OY, Zheng XY, Xu RA, Targher G, Byrne CD, Wang XD, Chen YP, Zheng MH
Journal of gastroenterology and hepatology 2021 Oct;36(10):2925-2934
Journal of gastroenterology and hepatology 2021 Oct;36(10):2925-2934
Compromised glutathione synthesis results in high susceptibility to acetaminophen hepatotoxicity in acatalasemic mice.
Ogino N, Nagaoka K, Tomizuka K, Matsuura-Harada Y, Eitoku M, Suganuma N, Ogino K
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Oct;156:112509
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Oct;156:112509
Hepatoprotective effects of ginsenoside Rk3 in acetaminophen-induced liver injury in mice by activation of autophagy.
Qu L, Fu R, Ma X, Fan D
Food & function 2021 Oct 4;12(19):9128-9140
Food & function 2021 Oct 4;12(19):9128-9140
MicroRNA-29b ameliorates hepatic inflammation via suppression of STAT3 in alcohol-associated liver disease.
Zhou K, Yin F, Li Y, Ma C, Liu P, Xin Z, Ren R, Wei S, Khan M, Wang H, Zhang H
Alcohol (Fayetteville, N.Y.) 2021 Oct 22;99:9-22
Alcohol (Fayetteville, N.Y.) 2021 Oct 22;99:9-22
Tryptophan Pathway-Targeted Metabolomics Study on the Mechanism and Intervention of Cisplatin-Induced Acute Kidney Injury in Rats.
Tan B, Chen J, Qin S, Liao C, Zhang Y, Wang D, Li S, Zhang Z, Zhang P, Xu F
Chemical research in toxicology 2021 Jul 19;34(7):1759-1768
Chemical research in toxicology 2021 Jul 19;34(7):1759-1768
Allicin alleviated acrylamide-induced NLRP3 inflammasome activation via oxidative stress and endoplasmic reticulum stress in Kupffer cells and SD rats liver.
Nan B, Yang C, Li L, Ye H, Yan H, Wang M, Yuan Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111937
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111937
Triptolide regulates oxidative stress and inflammation leading to hepatotoxicity via inducing CYP2E1.
Jiang HY, Bao YN, Lin FM, Jin Y
Human & experimental toxicology 2021 Dec;40(12_suppl):S775-S787
Human & experimental toxicology 2021 Dec;40(12_suppl):S775-S787
Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury.
Niu B, Lei X, Xu Q, Ju Y, Xu D, Mao L, Li J, Zheng Y, Sun N, Zhang X, Mao Y, Li X
Cell biology and toxicology 2021 Aug 17;
Cell biology and toxicology 2021 Aug 17;
Gut microbiota accelerates cisplatin-induced acute liver injury associated with robust inflammation and oxidative stress in mice.
Gong S, Feng Y, Zeng Y, Zhang H, Pan M, He F, Wu R, Chen J, Lu J, Zhang S, Yuan S, Chen X
Journal of translational medicine 2021 Apr 13;19(1):147
Journal of translational medicine 2021 Apr 13;19(1):147
Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis.
Zheng D, Jiang Y, Qu C, Yuan H, Hu K, He L, Chen P, Li J, Tu M, Lin L, Chen H, Lin Z, Lin W, Fan J, Cheng G, Hong J
The American journal of pathology 2020 Nov;190(11):2267-2281
The American journal of pathology 2020 Nov;190(11):2267-2281
circ-CBFB upregulates p66Shc to perturb mitochondrial dynamics in APAP-induced liver injury.
Wang Z, Zhao Y, Sun R, Sun Y, Liu D, Lin M, Chen Z, Zhou J, Lv L, Tian X, Yao J
Cell death & disease 2020 Nov 6;11(11):953
Cell death & disease 2020 Nov 6;11(11):953
Intrabody against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver injury in mice via concomitant promotion of angiogenesis and redox homeostasis.
Zhao L, Zhao J, Gao R, Tian Y, Zhang Y, Tang W, Jiang Y, Li C, Wang M, Yang F, Li G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109783
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109783
Intestinal Epithelial Chemokine (C-C Motif) Ligand 7 Overexpression Enhances Acetaminophen-Induced Hepatotoxicity in Mice.
Niu M, Luo Z, Gong S, Win S, Kaplowitz N, Jiang Y, Chen P
The American journal of pathology 2020 Jan;190(1):57-67
The American journal of pathology 2020 Jan;190(1):57-67
Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure.
Yamada N, Karasawa T, Kimura H, Watanabe S, Komada T, Kamata R, Sampilvanjil A, Ito J, Nakagawa K, Kuwata H, Hara S, Mizuta K, Sakuma Y, Sata N, Takahashi M
Cell death & disease 2020 Feb 24;11(2):144
Cell death & disease 2020 Feb 24;11(2):144
Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways.
Li Z, Lian Y, Wei R, Jin L, Cao H, Zhao T, Ma X, Zhong M, Gao Y, Zhang K
Life sciences 2020 Dec 1;262:118546
Life sciences 2020 Dec 1;262:118546
Knockdown of Long Noncoding RNAs Hepatocyte Nuclear Factor 1α Antisense RNA 1 and Hepatocyte Nuclear Factor 4α Antisense RNA 1 Alters Susceptibility of Acetaminophen-Induced Cytotoxicity in HepaRG Cells.
Chen L, Wang P, Manautou JE, Zhong XB
Molecular pharmacology 2020 Apr;97(4):278-286
Molecular pharmacology 2020 Apr;97(4):278-286
Chronic intake of high-dose of blueberry leaf extract does not augment the harmful effects of ethanol in rats.
Yamasaki K, Sugamoto K, Arakawa T, Nishiyama K, Yamasaki M
PeerJ 2019;7:e6989
PeerJ 2019;7:e6989
Inhibitory Effect of Corilagin on miR-21-Regulated Hepatic Fibrosis Signaling Pathway.
Zhou X, Xiong J, Lu S, Luo L, Chen ZL, Yang F, Jin F, Wang Y, Ma Q, Luo YY, Wang YJ, Zhou JB, Liu P, Zhao L
The American journal of Chinese medicine 2019;47(7):1541-1569
The American journal of Chinese medicine 2019;47(7):1541-1569
CCl4-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway.
Peng C, Zhou ZM, Li J, Luo Y, Zhou YS, Ke XH, Huang KE
Evidence-based complementary and alternative medicine : eCAM 2019;2019:5941263
Evidence-based complementary and alternative medicine : eCAM 2019;2019:5941263
Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae.
Yuan J, Chen C, Cui J, Lu J, Yan C, Wei X, Zhao X, Li N, Li S, Xue G, Cheng W, Li B, Li H, Lin W, Tian C, Zhao J, Han J, An D, Zhang Q, Wei H, Zheng M, Ma X, Li W, Chen X, Zhang Z, Zeng H, Ying S, Wu J, Yang R, Liu D
Cell metabolism 2019 Oct 1;30(4):675-688.e7
Cell metabolism 2019 Oct 1;30(4):675-688.e7
Neuroprotective Effect of Dioscin on the Aging Brain.
Qi Y, Li R, Xu L, Yin L, Xu Y, Han X, Peng J
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Inhibition of the mitochondrial complex-1 protects against carbon tetrachloride-induced acute liver injury.
Hua H, Zhang Z, Qian Y, Yuan H, Ge W, Huang S, Zhang A, Zhang Y, Jia Z, Ding G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108948
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108948
Benzene-induced mouse hematotoxicity is regulated by a protein phosphatase 2A complex that stimulates transcription of cytochrome P4502E1.
Chen L, Guo P, Zhang H, Li W, Gao C, Huang Z, Fan J, Zhang Y, Li X, Liu X, Wang F, Wang S, Li Q, He Z, Li H, Chen S, Wu X, Ye L, Li Q, Tang H, Wang Q, Dong G, Xiao Y, Chen W, Li D
The Journal of biological chemistry 2019 Feb 15;294(7):2486-2499
The Journal of biological chemistry 2019 Feb 15;294(7):2486-2499
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2019 Aug 1;10(8):5240-5241
Food & function 2019 Aug 1;10(8):5240-5241
Protective effects of ginsenoside Rk3 against chronic alcohol-induced liver injury in mice through inhibition of inflammation, oxidative stress, and apoptosis.
Qu L, Zhu Y, Liu Y, Yang H, Zhu C, Ma P, Deng J, Fan D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2019 Apr;126:277-284
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2019 Apr;126:277-284
Hepatoprotective Potential of Partially Hydrolyzed Guar Gum against Acute Alcohol-Induced Liver Injury in Vitro and Vivo.
Wu C, Liu J, Tang Y, Li Y, Yan Q, Jiang Z
Nutrients 2019 Apr 27;11(5)
Nutrients 2019 Apr 27;11(5)
Study on the potential way of hepatic cytotoxicity of N,N-dimethylformamide.
Li S, Wang C
Journal of biochemical and molecular toxicology 2018 Sep;32(9):e22190
Journal of biochemical and molecular toxicology 2018 Sep;32(9):e22190
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, Sun P, Huo X, Ma X, Meng Q, Liu K
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Neurotoxicity, behavioral changes and gene-expression profile of mice exposed to SnS2 nanoflowers.
Bai D, Li Q, Wang J, Zhao J, Deng X, Yuan L, Wu P
Toxicology research 2018 Nov 1;7(6):1267-1279
Toxicology research 2018 Nov 1;7(6):1267-1279
Schisantherin A alleviated alcohol-induced liver injury by the regulation of alcohol metabolism and NF-kB pathway.
Li B, Li D, Wang Y, Meng X, Sun X, Tian J, Shi L, Ma F
Experimental animals 2018 Nov 1;67(4):451-461
Experimental animals 2018 Nov 1;67(4):451-461
Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury.
Sun Y, Li TY, Song L, Zhang C, Li J, Lin ZZ, Lin SC, Lin SY
Hepatology (Baltimore, Md.) 2018 Jun;67(6):2397-2413
Hepatology (Baltimore, Md.) 2018 Jun;67(6):2397-2413
Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity.
Wang C, Xu W, Zhang Y, Huang D, Huang K
Cell death & disease 2018 Jul 26;9(8):819
Cell death & disease 2018 Jul 26;9(8):819
Salvianolic acid A alleviates chronic ethanol-induced liver injury via promotion of β-catenin nuclear accumulation by restoring SIRT1 in rats.
Shi X, Zhao Y, Ding C, Wang Z, Ji A, Li Z, Feng D, Li Y, Gao D, Zhou J, Tian X, Yao J
Toxicology and applied pharmacology 2018 Jul 1;350:21-31
Toxicology and applied pharmacology 2018 Jul 1;350:21-31
Decreased expression of hepatic cytochrome P450 1A2 (CYP1A2) in a chronic intermittent hypoxia mouse model.
Zhang XB, Zeng YM, Chen XY, Zhang YX, Ding JZ, Xue C
Journal of thoracic disease 2018 Feb;10(2):825-834
Journal of thoracic disease 2018 Feb;10(2):825-834
Hepatoprotective Effect of Polyphenol-Enriched Fraction from Folium Microcos on Oxidative Stress and Apoptosis in Acetaminophen-Induced Liver Injury in Mice.
Wu H, Zhang G, Huang L, Pang H, Zhang N, Chen Y, Wang G
Oxidative medicine and cellular longevity 2017;2017:3631565
Oxidative medicine and cellular longevity 2017;2017:3631565
Glycyrrhetinic acid prevents acetaminophen-induced acute liver injury via the inhibition of CYP2E1 expression and HMGB1-TLR4 signal activation in mice.
Yang G, Zhang L, Ma L, Jiang R, Kuang G, Li K, Tie H, Wang B, Chen X, Xie T, Gong X, Wan J
International immunopharmacology 2017 Sep;50:186-193
International immunopharmacology 2017 Sep;50:186-193
Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression.
Wang F, Liu JC, Zhou RJ, Zhao X, Liu M, Ye H, Xie ML
Chemico-biological interactions 2017 Sep 25;275:171-177
Chemico-biological interactions 2017 Sep 25;275:171-177
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Wang H, Xu YS, Wang ML, Cheng C, Bian R, Yuan H, Wang Y, Guo T, Zhu LL, Zhou H
International journal of molecular medicine 2017 Apr;39(4):819-830
International journal of molecular medicine 2017 Apr;39(4):819-830
Chronic Acrylamide Exposure in Male Mice Results in Elevated DNA Damage in the Germline and Heritable Induction of CYP2E1 in the Testes.
Katen AL, Chambers CG, Nixon B, Roman SD
Biology of reproduction 2016 Oct 1;95(4):86
Biology of reproduction 2016 Oct 1;95(4):86
Chronic plus binge ethanol exposure causes more severe pancreatic injury and inflammation.
Ren Z, Yang F, Wang X, Wang Y, Xu M, Frank JA, Ke ZJ, Zhang Z, Shi X, Luo J
Toxicology and applied pharmacology 2016 Oct 1;308:11-19
Toxicology and applied pharmacology 2016 Oct 1;308:11-19
Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress.
Shi H, Shi A, Dong L, Lu X, Wang Y, Zhao J, Dai F, Guo X
Clinical nutrition (Edinburgh, Scotland) 2016 Dec;35(6):1366-1373
Clinical nutrition (Edinburgh, Scotland) 2016 Dec;35(6):1366-1373
Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat.
Jiang W, Guo MH, Hai X
World journal of gastroenterology 2016 Dec 14;22(46):10180-10188
World journal of gastroenterology 2016 Dec 14;22(46):10180-10188
Alteration in the expression of cytochrome P450s (CYP1A1, CYP2E1, and CYP3A11) in the liver of mouse induced by microcystin-LR.
Zhang B, Liu Y, Li X
Toxins 2015 Mar 30;7(4):1102-15
Toxins 2015 Mar 30;7(4):1102-15
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Dong D, Yin L, Qi Y, Xu L, Peng J
Nutrients 2015 Jun 15;7(6):4829-50
Nutrients 2015 Jun 15;7(6):4829-50
Potent effects of dioscin against obesity in mice.
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973
Scientific reports 2015 Jan 22;5:7973
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Tao X, Wan X, Xu Y, Xu L, Qi Y, Yin L, Han X, Lin Y, Peng J
Transplantation 2014 Sep 27;98(6):604-11
Transplantation 2014 Sep 27;98(6):604-11
Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK/NF-κB pathway.
Ma JQ, Ding J, Zhang L, Liu CM
Environmental toxicology and pharmacology 2014 May;37(3):975-83
Environmental toxicology and pharmacology 2014 May;37(3):975-83
Protective effects of dioscin against alcohol-induced liver injury.
Xu T, Zheng L, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J
Archives of toxicology 2014 Mar;88(3):739-53
Archives of toxicology 2014 Mar;88(3):739-53
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2014 Dec;5(12):3065-3075
Food & function 2014 Dec;5(12):3065-3075
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Liu M, Xu Y, Han X, Liang C, Yin L, Xu L, Qi Y, Zhao Y, Peng J, Sun C
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Human placental lactogen induces CYP2E1 expression via PI 3-kinase pathway in female human hepatocytes.
Lee JK, Chung HJ, Fischer L, Fischer J, Gonzalez FJ, Jeong H
Drug metabolism and disposition: the biological fate of chemicals 2014 Apr;42(4):492-9
Drug metabolism and disposition: the biological fate of chemicals 2014 Apr;42(4):492-9
Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation.
Yu H, Zheng L, Yin L, Xu L, Qi Y, Han X, Xu Y, Liu K, Peng J
International immunopharmacology 2014 Apr;19(2):233-44
International immunopharmacology 2014 Apr;19(2):233-44
Protective effects of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.
Dong D, Zhang S, Yin L, Tang X, Xu Y, Han X, Qi Y, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:120-30
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:120-30
Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats.
Zhang S, Zheng L, Dong D, Xu L, Yin L, Qi Y, Han X, Lin Y, Liu K, Peng J
Food chemistry 2013 Dec 1;141(3):2108-16
Food chemistry 2013 Dec 1;141(3):2108-16
Protection of cyanidin-3-glucoside against oxidative stress induced by acrylamide in human MDA-MB-231 cells.
Song J, Zhao M, Liu X, Zhu Y, Hu X, Chen F
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Aug;58:306-10
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Aug;58:306-10
Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.
Zhao X, Cong X, Zheng L, Xu L, Yin L, Peng J
Toxicology letters 2012 Oct 2;214(1):69-80
Toxicology letters 2012 Oct 2;214(1):69-80
Protective effect of L-theanine on carbon tetrachloride-induced acute liver injury in mice.
Jiang W, Gao M, Sun S, Bi A, Xin Y, Han X, Wang L, Yin Z, Luo L
Biochemical and biophysical research communications 2012 Jun 1;422(2):344-50
Biochemical and biophysical research communications 2012 Jun 1;422(2):344-50
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 19937-1-AP(CYP2E1-Specific antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using CYP2E1 antibody 19937-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line