FNab10055

antibody from FineTest Biotech

Targeting: HMGCR

ELISA

Immunohistochemistry

Antibody data

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Validation data

Product number: FNab10055 - Provider product page
Provider: FineTest Biotech
Product name: HMGCR antibody
Antibody type: Polyclonal
Antigen: Recombinant protein fragment
Description: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Epitope: IgG
Isotype: IgG
Vial size: 100¦Ìg
Concentration: Immunogen affinity purified
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months (Avoid repeated freeze / thaw cycles.)
Handling: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months (Avoid repeated freeze / thaw cycles.)

HMGCR protein structure - FNab10055 shown in red.