Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-BL2486 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Anti-MOBKL1A monoclonal antibody, clone 3G9
- Antibody type
- Monoclonal
- Description
- Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3G9
- Storage
- Store at -2°C or lower. Aliquot to avoid repeated freezing and thawing.
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