KLF5

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Description

Kruppel like factor 5

Tissue specificity

Tissue enhanced (esophagus, skin)

Subcell location

Nucleoplasm, Golgi apparatus, Vesicles

Predicted location

Intracellular

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Transcription factors

Chromosome

13 (73054976 - 73077541)

Ensembl ID

ENSG00000102554  (ver. 103.38)

Orthologs

Mouse Klf5: ENSMUSG00000005148

UniProt

Q13887

neXtProt

NX_Q13887

Human splice variants
Mouse splice variants

Protein structure