AMM03671G

antibody from Leading Biology

Targeting: IL6ST CD130, GP130, sGP130

Western blot (Recommended by provider)

Antibody Data

Product number

AMM03671G

Provider

Leading Biology

Product name

IL6ST Antibody (monoclonal) (M02)

Antibody type

Monoclonal

Description

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

4A4

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.