Explore
Validate
Learn
Western blot
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- ABIN1105847 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) antibody
- Antibody type
- Monoclonal
- Description
- Ion Exchange Chromatography
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- B-P4
- Vial size
- 0.2 mg
- Storage
- Store the antibody undiluted at 2-8°C.
Submitted references N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.
Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor.
Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy.
The cytokine receptor gp130 and its soluble form are under hormonal control in human endometrium and decidua.
Polarity and lipid raft association of the components of the ciliary neurotrophic factor receptor complex in Madin-Darby canine kidney cells.
Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis.
A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor.
Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus.
Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited.
Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation.
The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130.
The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction.
Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130.
Two different epitopes of the signal transducer gp130 sequentially cooperate on IL-6-induced receptor activation.
SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130.
Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes.
Activation of the Janus kinase/signal transducer and activator of transcription pathway by osmotic shock.
Signaling of type II oncostatin M receptor.
Characterization of soluble gp130 released by melanoma cell lines: A polyvalent antagonist of cytokines from the interleukin 6 family.
Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties.
Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M.
Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein.
Waetzig GH, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl N, Vallés Uriarte L, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D
The Journal of biological chemistry 2010 Jan 15;285(3):1781-9
The Journal of biological chemistry 2010 Jan 15;285(3):1781-9
Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor.
Adam N, Rabe B, Suthaus J, Grötzinger J, Rose-John S, Scheller J
Journal of virology 2009 May;83(10):5117-26
Journal of virology 2009 May;83(10):5117-26
Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy.
Selander KS, Li L, Watson L, Merrell M, Dahmen H, Heinrich PC, Müller-Newen G, Harris KW
Cancer research 2004 Oct 1;64(19):6924-33
Cancer research 2004 Oct 1;64(19):6924-33
The cytokine receptor gp130 and its soluble form are under hormonal control in human endometrium and decidua.
Classen-Linke I, Müller-Newen G, Heinrich PC, Beier HM, von Rango U
Molecular human reproduction 2004 Jul;10(7):495-504
Molecular human reproduction 2004 Jul;10(7):495-504
Polarity and lipid raft association of the components of the ciliary neurotrophic factor receptor complex in Madin-Darby canine kidney cells.
Buk DM, Waibel M, Braig C, Martens AS, Heinrich PC, Graeve L
Journal of cell science 2004 Apr 15;117(Pt 10):2063-75
Journal of cell science 2004 Apr 15;117(Pt 10):2063-75
Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis.
Giese B, Au-Yeung CK, Herrmann A, Diefenbach S, Haan C, Küster A, Wortmann SB, Roderburg C, Heinrich PC, Behrmann I, Müller-Newen G
The Journal of biological chemistry 2003 Oct 3;278(40):39205-13
The Journal of biological chemistry 2003 Oct 3;278(40):39205-13
A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor.
Timmermann A, Küster A, Kurth I, Heinrich PC, Müller-Newen G
European journal of biochemistry 2002 Jun;269(11):2716-26
European journal of biochemistry 2002 Jun;269(11):2716-26
Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus.
Aoki Y, Narazaki M, Kishimoto T, Tosato G
Blood 2001 Nov 15;98(10):3042-9
Blood 2001 Nov 15;98(10):3042-9
Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited.
Friederichs K, Schmitz J, Weissenbach M, Heinrich PC, Schaper F
European journal of biochemistry 2001 Dec;268(24):6401-7
European journal of biochemistry 2001 Dec;268(24):6401-7
Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation.
Anhuf D, Weissenbach M, Schmitz J, Sobota R, Hermanns HM, Radtke S, Linnemann S, Behrmann I, Heinrich PC, Schaper F
Journal of immunology (Baltimore, Md. : 1950) 2000 Sep 1;165(5):2535-43
Journal of immunology (Baltimore, Md. : 1950) 2000 Sep 1;165(5):2535-43
The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130.
Terstegen L, Gatsios P, Bode JG, Schaper F, Heinrich PC, Graeve L
The Journal of biological chemistry 2000 Jun 23;275(25):18810-7
The Journal of biological chemistry 2000 Jun 23;275(25):18810-7
The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction.
Schmitz J, Dahmen H, Grimm C, Gendo C, Müller-Newen G, Heinrich PC, Schaper F
Journal of immunology (Baltimore, Md. : 1950) 2000 Jan 15;164(2):848-54
Journal of immunology (Baltimore, Md. : 1950) 2000 Jan 15;164(2):848-54
Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130.
Kurth I, Horsten U, Pflanz S, Timmermann A, Küster A, Dahmen H, Tacken I, Heinrich PC, Müller-Newen G
Journal of immunology (Baltimore, Md. : 1950) 2000 Jan 1;164(1):273-82
Journal of immunology (Baltimore, Md. : 1950) 2000 Jan 1;164(1):273-82
Two different epitopes of the signal transducer gp130 sequentially cooperate on IL-6-induced receptor activation.
Pflanz S, Kurth I, Grötzinger J, Heinrich PC, Müller-Newen G
Journal of immunology (Baltimore, Md. : 1950) 2000 Dec 15;165(12):7042-9
Journal of immunology (Baltimore, Md. : 1950) 2000 Dec 15;165(12):7042-9
SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130.
Schmitz J, Weissenbach M, Haan S, Heinrich PC, Schaper F
The Journal of biological chemistry 2000 Apr 28;275(17):12848-56
The Journal of biological chemistry 2000 Apr 28;275(17):12848-56
Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes.
Kurth I, Horsten U, Pflanz S, Dahmen H, Küster A, Grötzinger J, Heinrich PC, Müller-Newen G
Journal of immunology (Baltimore, Md. : 1950) 1999 Feb 1;162(3):1480-7
Journal of immunology (Baltimore, Md. : 1950) 1999 Feb 1;162(3):1480-7
Activation of the Janus kinase/signal transducer and activator of transcription pathway by osmotic shock.
Gatsios P, Terstegen L, Schliess F, Häussinger D, Kerr IM, Heinrich PC, Graeve L
The Journal of biological chemistry 1998 Sep 4;273(36):22962-8
The Journal of biological chemistry 1998 Sep 4;273(36):22962-8
Signaling of type II oncostatin M receptor.
Auguste P, Guillet C, Fourcin M, Olivier C, Veziers J, Pouplard-Barthelaix A, Gascan H
The Journal of biological chemistry 1997 Jun 20;272(25):15760-4
The Journal of biological chemistry 1997 Jun 20;272(25):15760-4
Characterization of soluble gp130 released by melanoma cell lines: A polyvalent antagonist of cytokines from the interleukin 6 family.
Montero-Julian FA, Brailly H, Sautès C, Joyeux I, Dorval T, Mosseri V, Yasukawa K, Wijdenes J, Adler A, Gorin I, Fridman WH, Tartour E
Clinical cancer research : an official journal of the American Association for Cancer Research 1997 Aug;3(8):1443-51
Clinical cancer research : an official journal of the American Association for Cancer Research 1997 Aug;3(8):1443-51
Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties.
Lebeau B, Montero Julian FA, Wijdenes J, Müller-Newen G, Dahmen H, Chérel M, Heinrich PC, Brailly H, Hallet MM, Godard A, Minvielle S, Jacques Y
FEBS letters 1997 Apr 28;407(2):141-7
FEBS letters 1997 Apr 28;407(2):141-7
Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M.
Gu ZJ, Wijdenes J, Zhang XG, Hallet MM, Clement C, Klein B
Journal of immunological methods 1996 Mar 28;190(1):21-7
Journal of immunological methods 1996 Mar 28;190(1):21-7
Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein.
Chevalier S, Fourcin M, Robledo O, Wijdenes J, Pouplard-Barthelaix A, Gascan H
The Journal of biological chemistry 1996 Jun 21;271(25):14764-72
The Journal of biological chemistry 1996 Jun 21;271(25):14764-72
No comments: Submit comment
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- FACS
