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Protein structure
RBFOX1
RNA binding fox-1 homolog 1A2BP1, FOX-1, HRNBP1
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Top validated antibodies |
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| Proteintech Group |  22647-1-AP |
1 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Novus Biologicals | NBP2-13169 |
2 references | Monoclonal |
WB
ICC
IP
IHC
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| Atlas Antibodies | HPA040809 |
Polyclonal |
WB
ICC
IHC
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| Invitrogen Antibodies | PA5-103622 |
1 references | Polyclonal |
WB
IHC
OA
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| antibodies-online | ABIN1580418 |
3 references | Monoclonal |
WB
ICC
IHC
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