OVOL2

This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016]

Description

Ovo like zinc finger 2

Tissue specificity

Tissue enhanced (salivary gland, stomach)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

20 (17956979 - 18059188)

Ensembl ID

ENSG00000125850  (ver. 103.38)

Orthologs

Mouse Ovol2: ENSMUSG00000037279

UniProt

Q9BRP0

neXtProt

NX_Q9BRP0

Human splice variants
Mouse splice variants

Protein structure