BS7743

antibody from Bioworld Technology, Inc
Targeting: ABAT GABA-T, GABAT
Provider product page for BS7743
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7743 - Provider product page
Provider
Bioworld Technology, Inc
Product name
ABAT polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human ABAT.
Description
In the central nervous system GABA (ÎÛ-;aminobutyric acid) functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. ABAT (4-aminobutyrate aminotransferase), also known as GABAT (GABA aminotransferase), L-AIBAT or (S)-3-amino-2-methylpropionate transaminase, is a 500 amino acid mitochondrial matrix protein belonging to the class-III pyridoxal-phosphate-dependent aminotransferase family, which catabolizes GABA into succinic semialdehyde. Existing as a homodimer, ABAT binds pyridoxal phosphate as a cofactor and is expressed in liver, brain, pancreas, kidney, placenta and heart. The gene encoding ABAT maps to human chromosome 16p13.2, and defects in ABAT are the cause of GABA-AT deficiency, which is characterized by hypotonia, hyperreflexia, psychomotor retardation, lethargy, EEG abnormalities and refractory seizures.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ABAT protein structure - BS7743 shown in red.