Antibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 10061-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10061-1-AP, RRID:AB_2236537
- Product name
- OS9 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated OS9 antibody (Cat. #10061-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Proteomic characterization of endogenous substrates of mammalian ubiquitin ligase Hrd1.
Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded α1-antitrypsin variant.
SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates.
Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans.
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.
Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.
OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum.
Ye Y, Baek SH, Ye Y, Zhang T
Cell & bioscience 2018;8:46
Cell & bioscience 2018;8:46
Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded α1-antitrypsin variant.
Fujimori T, Kamiya Y, Nagata K, Kato K, Hosokawa N
The FEBS journal 2013 Mar;280(6):1563-75
The FEBS journal 2013 Mar;280(6):1563-75
SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates.
Iida Y, Fujimori T, Okawa K, Nagata K, Wada I, Hosokawa N
The Journal of biological chemistry 2011 May 13;286(19):16929-39
The Journal of biological chemistry 2011 May 13;286(19):16929-39
Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans.
Hosokawa N, Kamiya Y, Kamiya D, Kato K, Nagata K
The Journal of biological chemistry 2009 Jun 19;284(25):17061-17068
The Journal of biological chemistry 2009 Jun 19;284(25):17061-17068
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.
Christianson JC, Shaler TA, Tyler RE, Kopito RR
Nature cell biology 2008 Mar;10(3):272-82
Nature cell biology 2008 Mar;10(3):272-82
Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.
Hosokawa N, Wada I, Nagasawa K, Moriyama T, Okawa K, Nagata K
The Journal of biological chemistry 2008 Jul 25;283(30):20914-24
The Journal of biological chemistry 2008 Jul 25;283(30):20914-24
OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum.
Wang Y, Fu X, Gaiser S, Köttgen M, Kramer-Zucker A, Walz G, Wegierski T
The Journal of biological chemistry 2007 Dec 14;282(50):36561-70
The Journal of biological chemistry 2007 Dec 14;282(50):36561-70
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10061-1-AP(OS9 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The OS9 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human OS9. This antibody recognizes human antigen. The OS9 antibody has been validated for the following applications: ELISA, WB, IHC analysis.