CABT-B1838

antibody from Creative Diagnostics

Targeting: TAB3 MAP3K7IP3

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B1838

Provider

Creative Diagnostics

Product name

Anti-TAB3 polyclonal antibody

Antibody type

Polyclonal

Description

TAB3 protein, or alternatively known as TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1 binding protein 3 (TAB-3), TGF-beta-activated kinase 1-binding protein 3 and encoded by the human gene named TAB3 or MAP3K7IP3 is a coordinating linker kinase in the TNF and IL-1 signaling pathways and also plays a role in the activation of the NF-kappa-B and AP1 gene activation pathways. These pathways play critical roles in many cellular pathways including immune responses, stress responses, apoptosis, proliferation and differentiation, and dysfunction of these pathways has been associated with numerous cancer and immune disorders. TAB3 is also involved in general MAPK activations and receptor signaling pathways, and TAB3 is important in Toll-like receptor signaling as well. TAB3 interacts with signaling partners TRAF6 and TRAF2 as well as TAB1, TAB2, and MAP3K7. The kinase is widely expressed in most tissues, and particularly upregulated in various cancer tissues.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 _L

Concentration

Please refer to lot specific datasheet.

Storage

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.