Antibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 12580-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12580-1-AP, RRID:AB_2096219
- Product name
- EDIL3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated EDIL3 antibody (Cat. #12580-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Del-1, an Endogenous Inhibitor of TGF-β Activation, Attenuates Fibrosis.
The secreted protein DEL-1 activates a β3 integrin-FAK-ERK1/2-RUNX2 pathway and promotes osteogenic differentiation and bone regeneration.
Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1.
Serum developmental endothelial locus-1 is associated with severity of sepsis in animals and humans.
EDIL3 depletion suppress epithelial-mesenchymal transition of lens epithelial cells via transforming growth factor β pathway.
The extracellular matrix protein Edil3 stimulates osteoblast differentiation through the integrin α5β1/ERK/Runx2 pathway.
EDIL3 knockdown inhibits retinal angiogenesis through the induction of cell cycle arrest in vitro.
Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche.
Endogenous developmental endothelial locus-1 limits ischaemia-related angiogenesis by blocking inflammation.
Overexpressed EDIL3 predicts poor prognosis and promotes anchorage-independent tumor growth in human pancreatic cancer.
Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis.
Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway.
DL-2-hydroxyisocaproic acid attenuates inflammatory responses in a murine Candida albicans biofilm model.
Elevated autocrine EDIL3 protects hepatocellular carcinoma from anoikis through RGD-mediated integrin activation.
Developmental endothelial locus-1 attenuates complement-dependent phagocytosis through inhibition of Mac-1-integrin.
Integrative analysis of congenital muscular torticollis: from gene expression to clinical significance.
Kim DY, Lee SH, Fu Y, Jing F, Kim WY, Hong SB, Song JA, Choe H, Ryu HJ, Kim M, Lim D, Kim MS, Yun CO, Lee T, Hyun H, Choi EY
Frontiers in immunology 2020;11:68
Frontiers in immunology 2020;11:68
The secreted protein DEL-1 activates a β3 integrin-FAK-ERK1/2-RUNX2 pathway and promotes osteogenic differentiation and bone regeneration.
Yuh DY, Maekawa T, Li X, Kajikawa T, Bdeir K, Chavakis T, Hajishengallis G
The Journal of biological chemistry 2020 May 22;295(21):7261-7273
The Journal of biological chemistry 2020 May 22;295(21):7261-7273
Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1.
Maekawa T, Tamura H, Domon H, Hiyoshi T, Isono T, Yonezawa D, Hayashi N, Takahashi N, Tabeta K, Maeda T, Oda M, Ziogas A, Alexaki VI, Chavakis T, Terao Y, Hajishengallis G
JCI insight 2020 Aug 6;5(15)
JCI insight 2020 Aug 6;5(15)
Serum developmental endothelial locus-1 is associated with severity of sepsis in animals and humans.
Kim WY, Lee SH, Kim DY, Ryu HJ, Chon GR, Park YY, Fu Y, Huh JW, Lim CM, Koh Y, Choi EY, Hong SB
Scientific reports 2019 Sep 10;9(1):13005
Scientific reports 2019 Sep 10;9(1):13005
EDIL3 depletion suppress epithelial-mesenchymal transition of lens epithelial cells via transforming growth factor β pathway.
Zhang R, Wei YH, Zhao CY, Song HY, Shen N, Cui X, Gao X, Qi ZT, Zhong M, Shen W
International journal of ophthalmology 2018;11(1):18-24
International journal of ophthalmology 2018;11(1):18-24
The extracellular matrix protein Edil3 stimulates osteoblast differentiation through the integrin α5β1/ERK/Runx2 pathway.
Oh SH, Kim JW, Kim Y, Lee MN, Kook MS, Choi EY, Im SY, Koh JT
PloS one 2017;12(11):e0188749
PloS one 2017;12(11):e0188749
EDIL3 knockdown inhibits retinal angiogenesis through the induction of cell cycle arrest in vitro.
Shen W, Zhu S, Qin H, Zhong M, Wu J, Zhang R, Song H
Molecular medicine reports 2017 Oct;16(4):4054-4060
Molecular medicine reports 2017 Oct;16(4):4054-4060
Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche.
Mitroulis I, Chen LS, Singh RP, Kourtzelis I, Economopoulou M, Kajikawa T, Troullinaki M, Ziogas A, Ruppova K, Hosur K, Maekawa T, Wang B, Subramanian P, Tonn T, Verginis P, von Bonin M, Wobus M, Bornhäuser M, Grinenko T, Di Scala M, Hidalgo A, Wielockx B, Hajishengallis G, Chavakis T
The Journal of clinical investigation 2017 Oct 2;127(10):3624-3639
The Journal of clinical investigation 2017 Oct 2;127(10):3624-3639
Endogenous developmental endothelial locus-1 limits ischaemia-related angiogenesis by blocking inflammation.
Klotzsche-von Ameln A, Cremer S, Hoffmann J, Schuster P, Khedr S, Korovina I, Troullinaki M, Neuwirth A, Sprott D, Chatzigeorgiou A, Economopoulou M, Orlandi A, Hain A, Zeiher AM, Deussen A, Hajishengallis G, Dimmeler S, Chavakis T, Chavakis E
Thrombosis and haemostasis 2017 Jun 2;117(6):1150-1163
Thrombosis and haemostasis 2017 Jun 2;117(6):1150-1163
Overexpressed EDIL3 predicts poor prognosis and promotes anchorage-independent tumor growth in human pancreatic cancer.
Jiang SH, Wang Y, Yang JY, Li J, Feng MX, Wang YH, Yang XM, He P, Tian GA, Zhang XX, Li Q, Cao XY, Huo YM, Yang MW, Fu XL, Li J, Liu DJ, Dai M, Wen SY, Gu JR, Hong J, Hua R, Zhang ZG, Sun YW
Oncotarget 2016 Jan 26;7(4):4226-40
Oncotarget 2016 Jan 26;7(4):4226-40
Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis.
Hellvard A, Zeitlmann L, Heiser U, Kehlen A, Niestroj A, Demuth HU, Koziel J, Delaleu N, Jan Potempa, Mydel P
Scientific reports 2016 Aug 11;6:31441
Scientific reports 2016 Aug 11;6:31441
Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway.
Maekawa T, Hosur K, Abe T, Kantarci A, Ziogas A, Wang B, Van Dyke TE, Chavakis T, Hajishengallis G
Nature communications 2015 Sep 16;6:8272
Nature communications 2015 Sep 16;6:8272
DL-2-hydroxyisocaproic acid attenuates inflammatory responses in a murine Candida albicans biofilm model.
Nieminen MT, Hernandez M, Novak-Frazer L, Kuula H, Ramage G, Bowyer P, Warn P, Sorsa T, Rautemaa R
Clinical and vaccine immunology : CVI 2014 Sep;21(9):1240-5
Clinical and vaccine immunology : CVI 2014 Sep;21(9):1240-5
Elevated autocrine EDIL3 protects hepatocellular carcinoma from anoikis through RGD-mediated integrin activation.
Feng MX, Ma MZ, Fu Y, Li J, Wang T, Xue F, Zhang JJ, Qin WX, Gu JR, Zhang ZG, Xia Q
Molecular cancer 2014 Oct 1;13:226
Molecular cancer 2014 Oct 1;13:226
Developmental endothelial locus-1 attenuates complement-dependent phagocytosis through inhibition of Mac-1-integrin.
Mitroulis I, Kang YY, Gahmberg CG, Siegert G, Hajishengallis G, Chavakis T, Choi EY
Thrombosis and haemostasis 2014 May 5;111(5):1004-6
Thrombosis and haemostasis 2014 May 5;111(5):1004-6
Integrative analysis of congenital muscular torticollis: from gene expression to clinical significance.
Yim SY, Yoon D, Park MC, Lee IJ, Kim JH, Lee MA, Kwack KS, Lee JD, Lee JH, Soh EY, Na YI, Park RW, Lee K, Jun JB
BMC medical genomics 2013;6 Suppl 2:S10
BMC medical genomics 2013;6 Suppl 2:S10
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human lung tissue were subjected to SDS PAGE followed by western blot with 12580-1-AP(EDIL3 antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 12580-1-AP(EDIL3 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The EDIL3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human EDIL3. This antibody recognizes human,mouse,rat antigen. The EDIL3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.