Antibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations [0]
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- Product number
- AF1109 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse Netrin-1 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse Netrin-1 in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant chicken (rch) Netrin-1 and recombinant human Netrin-1 is observed and less than 1% cross-reactivity with recombinant mouse (rm) Netrin-G1a and rmNetrin-4 is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
AAC52971
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Netrin 1 mediates protective effects exerted by insulin-like growth factor 1 on cochlear hair cells.
Netrin-1 Protects Hepatocytes Against Cell Death Through Sustained Translation During the Unfolded Protein Response.
Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.
Endothelial expression of guidance cues in vessel wall homeostasis dysregulation under proatherosclerotic conditions.
Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.
Interfering with multimerization of netrin-1 receptors triggers tumor cell death.
Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1.
Yamahara K, Nakagawa T, Ito J, Kinoshita K, Omori K, Yamamoto N
Neuropharmacology 2017 Jun;119:26-39
Neuropharmacology 2017 Jun;119:26-39
Netrin-1 Protects Hepatocytes Against Cell Death Through Sustained Translation During the Unfolded Protein Response.
Lahlali T, Plissonnier ML, Romero-López C, Michelet M, Ducarouge B, Berzal-Herranz A, Zoulim F, Mehlen P, Parent R
Cellular and molecular gastroenterology and hepatology 2016 May;2(3):281-301.e9
Cellular and molecular gastroenterology and hepatology 2016 May;2(3):281-301.e9
Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.
Ramkhelawon B, Hennessy EJ, Ménager M, Ray TD, Sheedy FJ, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner KJ, Moore KJ
Nature medicine 2014 Apr;20(4):377-84
Nature medicine 2014 Apr;20(4):377-84
Endothelial expression of guidance cues in vessel wall homeostasis dysregulation under proatherosclerotic conditions.
van Gils JM, Ramkhelawon B, Fernandes L, Stewart MC, Guo L, Seibert T, Menezes GB, Cara DC, Chow C, Kinane TB, Fisher EA, Balcells M, Alvarez-Leite J, Lacy-Hulbert A, Moore KJ
Arteriosclerosis, thrombosis, and vascular biology 2013 May;33(5):911-9
Arteriosclerosis, thrombosis, and vascular biology 2013 May;33(5):911-9
Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.
Shimizu A, Nakayama H, Wang P, König C, Akino T, Sandlund J, Coma S, Italiano JE Jr, Mammoto A, Bielenberg DR, Klagsbrun M
The Journal of biological chemistry 2013 Jan 25;288(4):2210-22
The Journal of biological chemistry 2013 Jan 25;288(4):2210-22
Interfering with multimerization of netrin-1 receptors triggers tumor cell death.
Mille F, Llambi F, Guix C, Delloye-Bourgeois C, Guenebeaud C, Castro-Obregon S, Bredesen DE, Thibert C, Mehlen P
Cell death and differentiation 2009 Oct;16(10):1344-51
Cell death and differentiation 2009 Oct;16(10):1344-51
Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1.
Causeret F, Hidalgo-Sanchez M, Fort P, Backer S, Popoff MR, Gauthier-Rouvière C, Bloch-Gallego E
Development (Cambridge, England) 2004 Jun;131(12):2841-52
Development (Cambridge, England) 2004 Jun;131(12):2841-52
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