Antibody data
- Antibody Data
- Antigen structure
- References [78]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 25537-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- YTHDF3-specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated YTHDF3-specific antibody (Cat. #25537-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Epstein-Barr virus suppresses N(6)-methyladenosine modification of TLR9 to promote immune evasion.
METTL3 enhances E. coli F18 resistance by targeting IKBKG/NF-κB signaling via an m(6)A-YTHDF1-dependent manner in IPEC-J2 cells.
Dynamics of N6-methyladenosine modification during Alzheimer's disease development.
miR615-3p inhibited FBLN1 and osteogenic differentiation of umbilical cord mesenchymal stem cells by associated with YTHDF2 in a m(6)A-miRNA interaction manner.
METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence.
m6A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB.
BIRC5 facilitates cisplatin-chemoresistance in a m(6)A-dependent manner in ovarian cancer.
YTHDF3 modulates the Cbln1 level by recruiting BTG2 and is implicated in the impaired cognition of prenatal hypoxia offspring.
RBMS1 Coordinates with the m(6)A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation.
Geniposide reduced oxidative stress-induced apoptosis in HK-2 cell through PI3K/AKT3/FOXO1 by m6A modification.
Pseudorabies virus exploits N(6)-methyladenosine modification to promote viral replication.
FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA.
YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules.
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins.
RNA m(6)A methylation modulates airway inflammation in allergic asthma via PTX3-dependent macrophage homeostasis.
m(6)A-modification of cyclin D1 and c-myc IRESs in glioblastoma controls ITAF activity and resistance to mTOR inhibition.
N6-methyladenosine modified LINC00901 promotes pancreatic cancer progression through IGF2BP2/MYC axis.
YTHDF2 Is Downregulated in Response to Host Shutoff Induced by DNA Virus Infection and Regulates Interferon-Stimulated Gene Expression.
Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice.
Comprehensive analysis of m6A methylation modification in chronic spinal cord injury in mice.
Newcastle disease virus activates methylation-related enzymes to reprogram m(6)A methylation in infected cells.
METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression.
N(6)-methyladenosine reader YTHDF3 contributes to the aerobic glycolysis of osteosarcoma through stabilizing PGK1 stability.
Circular RNA encoded MET variant promotes glioblastoma tumorigenesis.
Involvement of METTL3 in arsenite-induced skin lesions by targeting the SOCS3/STAT3/Krt signaling pathway.
Polychlorinated biphenyls alter hepatic m6A mRNA methylation in a mouse model of environmental liver disease.
Regulators of proteostasis are translationally repressed in fibroblasts from patients with sporadic and LRRK2-G2019S Parkinson's disease.
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
Early enterovirus translation deficits extend viral RNA replication and elicit sustained MDA5-directed innate signaling.
Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer.
A positive feedback circuit driven by m(6)A-modified circular RNA facilitates colorectal cancer liver metastasis.
m(6)A reader YTHDF3 is associated with clinical prognosis, related RNA signatures and immunosuppression in gastric cancer.
Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions.
Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts.
Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.
N(6)-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis.
Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N(6)-Methyladenosine-Modified Yap Expression.
N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments.
Integrated Clinical and Prognostic Analysis of the m(6)A RNA Methylation Regulator YTHDF3 in Pan-Cancer and its Correlation with Cancer Cell Proliferation.
m(6)A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress.
m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.
Combination of high-fat diet and cadmium impairs testicular spermatogenesis in an m6A-YTHDF2-dependent manner.
MiR-30e-3p inhibits gastric cancer development by negatively regulating THO complex 2 and PI3K/AKT/mTOR signaling.
Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.
YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer.
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity.
RNA m(6)A Alterations Induced by Biomineralization Nanoparticles: A Proof-of-Concept Study of Epitranscriptomics for Nanotoxicity Evaluation.
The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.
Novel stress granule-like structures are induced via a paracrine mechanism during viral infection.
Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.
Dynamic Alteration Profile and New Role of RNA m6A Methylation in Replicative and H(2)O(2)-Induced Premature Senescence of Human Embryonic Lung Fibroblasts.
N6-methyladenosine regulates ATM expression and downstream signaling.
Differential roles of YTHDF1 and YTHDF3 in embryonic stem cell-derived cardiomyocyte differentiation.
METTL3-dependent RNA m(6)A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.
Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression.
Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
MYC promotes cancer progression by modulating m(6) A modifications to suppress target gene translation.
METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding.
KDM5B promotes self-renewal of hepatocellular carcinoma cells through the microRNA-448-mediated YTHDF3/ITGA6 axis.
Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.
GR-mediated transcriptional regulation of m(6)A metabolic genes contributes to diet-induced fatty liver in hens.
TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
m(6)A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation.
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.
Enterovirus 2A(pro) Cleavage of the YTHDF m(6)A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.
m(6)A-binding YTHDF proteins promote stress granule formation.
Modulation of circRNA Metabolism by m(6)A Modification.
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation.
HIV protease cleaves the antiviral m6A reader protein YTHDF3 in the viral particle.
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1.
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
Dynamic m(6)A mRNA methylation reveals the role of METTL3-m(6)A-CDCP1 signaling axis in chemical carcinogenesis.
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.
m(6)A facilitates hippocampus-dependent learning and memory through YTHDF1.
RNA m(6) A modification enzymes shape innate responses to DNA by regulating interferon β.
Zhang X, Li Z, Peng Q, Liu C, Wu Y, Wen Y, Zheng R, Xu C, Tian J, Zheng X, Yan Q, Wang J, Ma J
The Journal of biological chemistry 2024 May;300(5):107226
The Journal of biological chemistry 2024 May;300(5):107226
METTL3 enhances E. coli F18 resistance by targeting IKBKG/NF-κB signaling via an m(6)A-YTHDF1-dependent manner in IPEC-J2 cells.
Jin J, Liu M, Yu F, Sun MA, Wu Z
International journal of biological macromolecules 2024 Mar;262(Pt 2):130101
International journal of biological macromolecules 2024 Mar;262(Pt 2):130101
Dynamics of N6-methyladenosine modification during Alzheimer's disease development.
Gao S, Wang Y, Li X, Liang Y, Jin Z, Yang B, Yuan TF, Tian H, Peng B, Rao Y
Heliyon 2024 Mar 30;10(6):e26911
Heliyon 2024 Mar 30;10(6):e26911
miR615-3p inhibited FBLN1 and osteogenic differentiation of umbilical cord mesenchymal stem cells by associated with YTHDF2 in a m(6)A-miRNA interaction manner.
Yang H, Wang W, Liu H, Zhang C, Cao Y, Long L, Han X, Wang Y, Yan F, Li G, Zhu M, Jin L, Fan Z
Cell proliferation 2024 Jun;57(6):e13607
Cell proliferation 2024 Jun;57(6):e13607
METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence.
Wang C, Tanizawa H, Hill C, Havas A, Zhang Q, Liao L, Hao X, Lei X, Wang L, Nie H, Qi Y, Tian B, Gardini A, Kossenkov AV, Goldman A, Berger SL, Noma KI, Adams PD, Zhang R
Nature communications 2024 Jun 26;15(1):5410
Nature communications 2024 Jun 26;15(1):5410
m6A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB.
Shu F, Liu H, Chen X, Liu Y, Zhou J, Tang L, Cao W, Yang S, Long Y, Li R, Wang H, Wang H, Jiang G
Cancer research 2024 Jun 14;84(12):1947-1962
Cancer research 2024 Jun 14;84(12):1947-1962
BIRC5 facilitates cisplatin-chemoresistance in a m(6)A-dependent manner in ovarian cancer.
Fan Y, Pan Y, Jia L, Gu S, Liu B, Mei Z, Lv C, Huang H, Zhu G, Deng Q
Cancer medicine 2024 Jan;13(1):e6811
Cancer medicine 2024 Jan;13(1):e6811
YTHDF3 modulates the Cbln1 level by recruiting BTG2 and is implicated in the impaired cognition of prenatal hypoxia offspring.
Lu L, Shi Y, Wei B, Li W, Yu X, Zhao Y, Yu D, Sun M
iScience 2024 Jan 19;27(1):108703
iScience 2024 Jan 19;27(1):108703
RBMS1 Coordinates with the m(6)A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation.
Sun Y, Chen D, Sun S, Ren M, Zhou L, Chen C, Zhao J, Wei H, Zhao Q, Qi Y, Zhang J, Zhang G, Liu H, Yang Q, Liu Q, Wang Y, Zhang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(15):e2307122
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(15):e2307122
Geniposide reduced oxidative stress-induced apoptosis in HK-2 cell through PI3K/AKT3/FOXO1 by m6A modification.
Cheng W, Tan L, Yu S, Song J, Li Z, Peng X, Wei Q, He Z, Zhang W, Yang X
International immunopharmacology 2024 Apr 20;131:111820
International immunopharmacology 2024 Apr 20;131:111820
Pseudorabies virus exploits N(6)-methyladenosine modification to promote viral replication.
Yu PL, Wu R, Cao SJ, Wen YP, Huang XB, Zhao S, Lang YF, Zhao Q, Lin JC, Du SY, Yu SM, Yan QG
Frontiers in microbiology 2023;14:1087484
Frontiers in microbiology 2023;14:1087484
FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA.
Geng Y, Long X, Zhang Y, Wang Y, You G, Guo W, Zhuang G, Zhang Y, Cheng X, Yuan Z, Zan J
Journal of translational medicine 2023 Sep 22;21(1):652
Journal of translational medicine 2023 Sep 22;21(1):652
YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules.
Yang W, Zhang M, Li J, Qu S, Zhou F, Liu M, Li L, Liu Z, Zen K
Redox biology 2023 Nov;67:102921
Redox biology 2023 Nov;67:102921
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins.
Chen Y, Wan R, Zou Z, Lao L, Shao G, Zheng Y, Tang L, Yuan Y, Ge Y, He C, Lin S
Nature cell biology 2023 Nov;25(11):1676-1690
Nature cell biology 2023 Nov;25(11):1676-1690
RNA m(6)A methylation modulates airway inflammation in allergic asthma via PTX3-dependent macrophage homeostasis.
Han X, Liu L, Huang S, Xiao W, Gao Y, Zhou W, Zhang C, Zheng H, Yang L, Xie X, Liang Q, Tu Z, Yu H, Fu J, Wang L, Zhang X, Qian L, Zhou Y
Nature communications 2023 Nov 13;14(1):7328
Nature communications 2023 Nov 13;14(1):7328
m(6)A-modification of cyclin D1 and c-myc IRESs in glioblastoma controls ITAF activity and resistance to mTOR inhibition.
Benavides-Serrato A, Saunders JT, Kumar S, Holmes B, Benavides KE, Bashir MT, Nishimura RN, Gera J
Cancer letters 2023 May 28;562:216178
Cancer letters 2023 May 28;562:216178
N6-methyladenosine modified LINC00901 promotes pancreatic cancer progression through IGF2BP2/MYC axis.
Peng WX, Liu F, Jiang JH, Yuan H, Zhang Z, Yang L, Mo YY
Genes & diseases 2023 Mar;10(2):554-567
Genes & diseases 2023 Mar;10(2):554-567
YTHDF2 Is Downregulated in Response to Host Shutoff Induced by DNA Virus Infection and Regulates Interferon-Stimulated Gene Expression.
Hesser CR, Walsh D
Journal of virology 2023 Mar 30;97(3):e0175822
Journal of virology 2023 Mar 30;97(3):e0175822
Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice.
Yan S, Zhou X, Wu C, Gao Y, Qian Y, Hou J, Xie R, Han B, Chen Z, Wei S, Gao X
Nature communications 2023 Mar 13;14(1):1379
Nature communications 2023 Mar 13;14(1):1379
Comprehensive analysis of m6A methylation modification in chronic spinal cord injury in mice.
Li C, Zhao J, Qin T, Jin Y, Duan C, Wu T, Romani MD, Cao Y, Lu H, Hu J
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2023 Jun;41(6):1320-1334
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2023 Jun;41(6):1320-1334
Newcastle disease virus activates methylation-related enzymes to reprogram m(6)A methylation in infected cells.
Yuan W, Hou Y, Wang Q, Lv T, Ren J, Fan L, Cai J, Xiang B, Lin Q, Liao M, Ding C, Chen L, Ren T
Veterinary microbiology 2023 Jun;281:109747
Veterinary microbiology 2023 Jun;281:109747
METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression.
Wei W, Zhang ZY, Shi B, Cai Y, Zhang HS, Sun CL, Fei YF, Zhong W, Zhang S, Wang C, He B, Jiang GM, Wang H
Journal of experimental & clinical cancer research : CR 2023 Jun 20;42(1):151
Journal of experimental & clinical cancer research : CR 2023 Jun 20;42(1):151
N(6)-methyladenosine reader YTHDF3 contributes to the aerobic glycolysis of osteosarcoma through stabilizing PGK1 stability.
Liu D, Li Z, Zhang K, Lu D, Zhou D, Meng Y
Journal of cancer research and clinical oncology 2023 Jul;149(8):4601-4610
Journal of cancer research and clinical oncology 2023 Jul;149(8):4601-4610
Circular RNA encoded MET variant promotes glioblastoma tumorigenesis.
Zhong J, Wu X, Gao Y, Chen J, Zhang M, Zhou H, Yang J, Xiao F, Yang X, Huang N, Qi H, Wang X, Bai F, Shi Y, Zhang N
Nature communications 2023 Jul 25;14(1):4467
Nature communications 2023 Jul 25;14(1):4467
Involvement of METTL3 in arsenite-induced skin lesions by targeting the SOCS3/STAT3/Krt signaling pathway.
Yang F, Zhang A
Environmental pollution (Barking, Essex : 1987) 2023 Jan 1;316(Pt 2):120634
Environmental pollution (Barking, Essex : 1987) 2023 Jan 1;316(Pt 2):120634
Polychlorinated biphenyls alter hepatic m6A mRNA methylation in a mouse model of environmental liver disease.
Petri BJ, Piell KM, Wahlang B, Head KZ, Andreeva K, Rouchka EC, Cave MC, Klinge CM
Environmental research 2023 Jan 1;216(Pt 3):114686
Environmental research 2023 Jan 1;216(Pt 3):114686
Regulators of proteostasis are translationally repressed in fibroblasts from patients with sporadic and LRRK2-G2019S Parkinson's disease.
Flinkman D, Hong Y, Gnjatovic J, Deshpande P, Ortutay Z, Peltonen S, Kaasinen V, James P, Coffey E
NPJ Parkinson's disease 2023 Feb 6;9(1):20
NPJ Parkinson's disease 2023 Feb 6;9(1):20
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
Sun L, Suo C, Zhang T, Shen S, Gu X, Qiu S, Zhang P, Wei H, Ma W, Yan R, Chen R, Jia W, Cao J, Zhang H, Gao P
Nature chemical biology 2023 Dec;19(12):1492-1503
Nature chemical biology 2023 Dec;19(12):1492-1503
Early enterovirus translation deficits extend viral RNA replication and elicit sustained MDA5-directed innate signaling.
Dobrikov MI, Dobrikova EY, Nardone-White DT, McKay ZP, Brown MC, Gromeier M
mBio 2023 Dec 19;14(6):e0191523
mBio 2023 Dec 19;14(6):e0191523
Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer.
Zhang G, Mi W, Wang C, Li J, Zhang Y, Liu N, Jiang M, Jia G, Wang F, Yang G, Zhang L, Wang J, Fu Y, Zhang Y
Cell death discovery 2023 Dec 15;9(1):457
Cell death discovery 2023 Dec 15;9(1):457
A positive feedback circuit driven by m(6)A-modified circular RNA facilitates colorectal cancer liver metastasis.
Zeng K, Peng J, Xing Y, Zhang L, Zeng P, Li W, Zhang W, Pan Z, Zhou C, Lin J
Molecular cancer 2023 Dec 13;22(1):202
Molecular cancer 2023 Dec 13;22(1):202
m(6)A reader YTHDF3 is associated with clinical prognosis, related RNA signatures and immunosuppression in gastric cancer.
Yu Y, Meng LL, Chen XY, Fan HN, Chen M, Zhang J, Zhu JS
Cellular signalling 2023 Aug;108:110699
Cellular signalling 2023 Aug;108:110699
Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions.
Park J, Wu Y, Shao W, Gendron TF, van der Spek SJF, Sultanakhmetov G, Basu A, Castellanos Otero P, Jones CJ, Jansen-West K, Daughrity LM, Phanse S, Del Rosso G, Tong J, Castanedes-Casey M, Jiang L, Libera J, Oskarsson B, Dickson DW, Sanders DW, Brangwynne CP, Emili A, Wolozin B, Petrucelli L, Zhang YJ
Cell reports 2023 Aug 29;42(8):112822
Cell reports 2023 Aug 29;42(8):112822
Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts.
Jansens RJJ, Olarerin-George A, Verhamme R, Mirza A, Jaffrey S, Favoreel HW
iScience 2023 Aug 18;26(8):107310
iScience 2023 Aug 18;26(8):107310
Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.
Pan Y, Gu Y, Liu T, Zhang Q, Yang F, Duan L, Cheng S, Zhu X, Xi Y, Chang X, Ye Q, Gao S
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120
N(6)-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis.
Ji D, Hu C, Ning J, Ying X, Zhang H, Zhang B, Liu B, Liu Q, Ji W, Zhang R
Ecotoxicology and environmental safety 2023 Apr 1;254:114755
Ecotoxicology and environmental safety 2023 Apr 1;254:114755
Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N(6)-Methyladenosine-Modified Yap Expression.
Wang L, Yu P, Wang J, Xu G, Wang T, Feng J, Bei Y, Xu J, Wang H, Das S, Xiao J
Research (Washington, D.C.) 2022;2022:9825916
Research (Washington, D.C.) 2022;2022:9825916
N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments.
Hu Z, Li Y, Yuan W, Jin L, Leung WK, Zhang C, Yang Y
International journal of biological sciences 2022;18(15):5753-5769
International journal of biological sciences 2022;18(15):5753-5769
Integrated Clinical and Prognostic Analysis of the m(6)A RNA Methylation Regulator YTHDF3 in Pan-Cancer and its Correlation with Cancer Cell Proliferation.
Cao L, Zeng B, Wang Y, Wang X, Qin Y, Zhang C, Wu M, Wang J, Zhang X, Ma L
Journal of Cancer 2022;13(15):3623-3639
Journal of Cancer 2022;13(15):3623-3639
m(6)A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress.
Wang L, Zhan G, Maimaitiyiming Y, Su Y, Lin S, Liu J, Su K, Lin J, Shen S, He W, Wang F, Chen J, Sun S, Xue Y, Gu J, Chen X, Zhang J, Zhang L, Wang Q, Chang KJ, Chiou SH, Björklund M, Naranmandura H, Cheng X, Hsu CH
Cell reports 2022 Oct 25;41(4):111546
Cell reports 2022 Oct 25;41(4):111546
m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.
Suphakhong K, Terashima M, Wanna-Udom S, Takatsuka R, Ishimura A, Takino T, Suzuki T
The Journal of biological chemistry 2022 Nov;298(11):102554
The Journal of biological chemistry 2022 Nov;298(11):102554
Combination of high-fat diet and cadmium impairs testicular spermatogenesis in an m6A-YTHDF2-dependent manner.
Xiong YW, Tan LL, Zhang J, Zhu HL, Zheng XM, Chang W, Gao L, Wei T, Xu DX, Wang H
Environmental pollution (Barking, Essex : 1987) 2022 Nov 15;313:120112
Environmental pollution (Barking, Essex : 1987) 2022 Nov 15;313:120112
MiR-30e-3p inhibits gastric cancer development by negatively regulating THO complex 2 and PI3K/AKT/mTOR signaling.
Gu XJ, Li YJ, Wang F, Ye T
World journal of gastrointestinal oncology 2022 Nov 15;14(11):2170-2182
World journal of gastrointestinal oncology 2022 Nov 15;14(11):2170-2182
Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.
Chen S, Zhang L, Li M, Zhang Y, Sun M, Wang L, Lin J, Cui Y, Chen Q, Jin C, Li X, Wang B, Chen H, Zhou T, Wang L, Hsu CH, Zhuo W
Nature communications 2022 Mar 10;13(1):1248
Nature communications 2022 Mar 10;13(1):1248
YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer.
Zhao Y, Zhao H, Zhang D, Quan Q, Ge Y, Li L, Guo L
ACS chemical biology 2022 Jul 15;17(7):1778-1788
ACS chemical biology 2022 Jul 15;17(7):1778-1788
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity.
N'Da Konan S, Ségéral E, Bejjani F, Bendoumou M, Ait Said M, Gallois-Montbrun S, Emiliani S
Retrovirology 2022 Jan 31;19(1):4
Retrovirology 2022 Jan 31;19(1):4
RNA m(6)A Alterations Induced by Biomineralization Nanoparticles: A Proof-of-Concept Study of Epitranscriptomics for Nanotoxicity Evaluation.
Pan J, Wang J, Fang K, Hou W, Li B, Zhao J, Ma X
Nanoscale research letters 2022 Feb 5;17(1):23
Nanoscale research letters 2022 Feb 5;17(1):23
The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.
Li M, Zhong X, Zhao Z, Zeng Z, Yuan Q, Xiao X, Zu X, Liu J
Brain research 2022 Feb 15;1777:147766
Brain research 2022 Feb 15;1777:147766
Novel stress granule-like structures are induced via a paracrine mechanism during viral infection.
Iadevaia V, Burke JM, Eke L, Moller-Levet C, Parker R, Locker N
Journal of cell science 2022 Feb 15;135(4)
Journal of cell science 2022 Feb 15;135(4)
Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.
Sun Z, Chen W, Wang Z, Wang S, Zan J, Zheng L, Zhao W
Clinical immunology (Orlando, Fla.) 2022 Dec;245:109176
Clinical immunology (Orlando, Fla.) 2022 Dec;245:109176
Dynamic Alteration Profile and New Role of RNA m6A Methylation in Replicative and H(2)O(2)-Induced Premature Senescence of Human Embryonic Lung Fibroblasts.
Wu F, Zhang L, Lai C, Peng X, Yu S, Zhou C, Zhang B, Zhang W
International journal of molecular sciences 2022 Aug 17;23(16)
International journal of molecular sciences 2022 Aug 17;23(16)
N6-methyladenosine regulates ATM expression and downstream signaling.
Zhang X, Liu P, Zheng X, Wang J, Peng Q, Li Z, Wei L, Liu C, Wu Y, Wen Y, Yan Q, Ma J
Journal of Cancer 2021;12(23):7041-7051
Journal of Cancer 2021;12(23):7041-7051
Differential roles of YTHDF1 and YTHDF3 in embryonic stem cell-derived cardiomyocyte differentiation.
Wang S, Zhang J, Wu X, Lin X, Liu XM, Zhou J
RNA biology 2021 Sep;18(9):1354-1363
RNA biology 2021 Sep;18(9):1354-1363
METTL3-dependent RNA m(6)A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.
Zhao F, Xu Y, Gao S, Qin L, Austria Q, Siedlak SL, Pajdzik K, Dai Q, He C, Wang W, O'Donnell JM, Tang B, Zhu X
Molecular neurodegeneration 2021 Sep 30;16(1):70
Molecular neurodegeneration 2021 Sep 30;16(1):70
Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression.
He RZ, Jiang J, Hu X, Lei M, Li J, Luo W, Duan L, Hu Z, Mo YY, Luo DX, Peng WX
Cancer cell international 2021 Nov 22;21(1):616
Cancer cell international 2021 Nov 22;21(1):616
Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
Peng F, Xu J, Cui B, Liang Q, Zeng S, He B, Zou H, Li M, Zhao H, Meng Y, Chen J, Liu B, Lv S, Chu P, An F, Wang Z, Huang J, Zhan Y, Liao Y, Lu J, Xu L, Zhang J, Sun Z, Li Z, Wang F, Lam EW, Liu Q
Cell research 2021 Mar;31(3):345-361
Cell research 2021 Mar;31(3):345-361
MYC promotes cancer progression by modulating m(6) A modifications to suppress target gene translation.
Wu G, Suo C, Yang Y, Shen S, Sun L, Li ST, Zhou Y, Yang D, Wang Y, Cai Y, Wang N, Zhang H, Yang YG, Cao J, Gao P
EMBO reports 2021 Mar 3;22(3):e51519
EMBO reports 2021 Mar 3;22(3):e51519
METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding.
Wang W, Shao F, Yang X, Wang J, Zhu R, Yang Y, Zhao G, Guo D, Sun Y, Wang J, Xue Q, Gao S, Gao Y, He J, Lu Z
Nature communications 2021 Jun 21;12(1):3803
Nature communications 2021 Jun 21;12(1):3803
KDM5B promotes self-renewal of hepatocellular carcinoma cells through the microRNA-448-mediated YTHDF3/ITGA6 axis.
Guo JC, Liu Z, Yang YJ, Guo M, Zhang JQ, Zheng JF
Journal of cellular and molecular medicine 2021 Jul;25(13):5949-5962
Journal of cellular and molecular medicine 2021 Jul;25(13):5949-5962
Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.
Xia Z, Tang M, Ma J, Zhang H, Gimple RC, Prager BC, Tang H, Sun C, Liu F, Lin P, Mei Y, Du R, Rich JN, Xie Q
Nucleic acids research 2021 Jul 21;49(13):7361-7374
Nucleic acids research 2021 Jul 21;49(13):7361-7374
GR-mediated transcriptional regulation of m(6)A metabolic genes contributes to diet-induced fatty liver in hens.
Feng Y, Li Y, Jiang W, Hu Y, Jia Y, Zhao R
Journal of animal science and biotechnology 2021 Dec 7;12(1):117
Journal of animal science and biotechnology 2021 Dec 7;12(1):117
TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
Wang H, Wei W, Zhang ZY, Liu Y, Shi B, Zhong W, Zhang HS, Fang X, Sun CL, Wang JB, Liu LX
Cell death & disease 2021 Dec 17;13(1):3
Cell death & disease 2021 Dec 17;13(1):3
m(6)A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation.
Zhang JX, Huang PJ, Wang DP, Yang WY, Lu J, Zhu Y, Meng XX, Wu X, Lin QH, Lv H, Xie H, Wang RL
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Dec 1;29(12):3436-3448
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Dec 1;29(12):3436-3448
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.
Ma S, Yan J, Barr T, Zhang J, Chen Z, Wang LS, Sun JC, Chen J, Caligiuri MA, Yu J
The Journal of experimental medicine 2021 Aug 2;218(8)
The Journal of experimental medicine 2021 Aug 2;218(8)
Enterovirus 2A(pro) Cleavage of the YTHDF m(6)A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.
Kastan JP, Tremblay MW, Brown MC, Trimarco JD, Dobrikova EY, Dobrikov MI, Gromeier M
mBio 2021 Apr 13;12(2)
mBio 2021 Apr 13;12(2)
m(6)A-binding YTHDF proteins promote stress granule formation.
Fu Y, Zhuang X
Nature chemical biology 2020 Sep;16(9):955-963
Nature chemical biology 2020 Sep;16(9):955-963
Modulation of circRNA Metabolism by m(6)A Modification.
Di Timoteo G, Dattilo D, Centrón-Broco A, Colantoni A, Guarnacci M, Rossi F, Incarnato D, Oliviero S, Fatica A, Morlando M, Bozzoni I
Cell reports 2020 May 12;31(6):107641
Cell reports 2020 May 12;31(6):107641
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
Sheng H, Li Z, Su S, Sun W, Zhang X, Li L, Li J, Liu S, Lu B, Zhang S, Shan C
Carcinogenesis 2020 Jul 10;41(5):541-550
Carcinogenesis 2020 Jul 10;41(5):541-550
Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation.
Brocard M, Iadevaia V, Klein P, Hall B, Lewis G, Lu J, Burke J, Willcocks MM, Parker R, Goodfellow IG, Ruggieri A, Locker N
PLoS pathogens 2020 Jan;16(1):e1008250
PLoS pathogens 2020 Jan;16(1):e1008250
HIV protease cleaves the antiviral m6A reader protein YTHDF3 in the viral particle.
Jurczyszak D, Zhang W, Terry SN, Kehrer T, Bermúdez González MC, McGregor E, Mulder LCF, Eckwahl MJ, Pan T, Simon V
PLoS pathogens 2020 Feb;16(2):e1008305
PLoS pathogens 2020 Feb;16(2):e1008305
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
Zhang Y, Liu X, Liu L, Li J, Hu Q, Sun R
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1.
Yarmishyn AA, Yang YP, Lu KH, Chen YC, Chien Y, Chou SJ, Tsai PH, Ma HI, Chien CS, Chen MT, Wang ML
Cancer cell international 2020 Dec 14;20(1):597
Cancer cell international 2020 Dec 14;20(1):597
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
Wang Y, Gao M, Zhu F, Li X, Yang Y, Yan Q, Jia L, Xie L, Chen Z
Nature communications 2020 Apr 3;11(1):1648
Nature communications 2020 Apr 3;11(1):1648
Dynamic m(6)A mRNA methylation reveals the role of METTL3-m(6)A-CDCP1 signaling axis in chemical carcinogenesis.
Yang F, Jin H, Que B, Chao Y, Zhang H, Ying X, Zhou Z, Yuan Z, Su J, Wu B, Zhang W, Qi D, Chen D, Min W, Lin S, Ji W
Oncogene 2019 Jun;38(24):4755-4772
Oncogene 2019 Jun;38(24):4755-4772
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.
Hao H, Hao S, Chen H, Chen Z, Zhang Y, Wang J, Wang H, Zhang B, Qiu J, Deng F, Guan W
Nucleic acids research 2019 Jan 10;47(1):362-374
Nucleic acids research 2019 Jan 10;47(1):362-374
m(6)A facilitates hippocampus-dependent learning and memory through YTHDF1.
Shi H, Zhang X, Weng YL, Lu Z, Liu Y, Lu Z, Li J, Hao P, Zhang Y, Zhang F, Wu Y, Delgado JY, Su Y, Patel MJ, Cao X, Shen B, Huang X, Ming GL, Zhuang X, Song H, He C, Zhou T
Nature 2018 Nov;563(7730):249-253
Nature 2018 Nov;563(7730):249-253
RNA m(6) A modification enzymes shape innate responses to DNA by regulating interferon β.
Rubio RM, Depledge DP, Bianco C, Thompson L, Mohr I
Genes & development 2018 Dec 1;32(23-24):1472-1484
Genes & development 2018 Dec 1;32(23-24):1472-1484
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The YTHDF3 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human YTHDF3. This antibody recognizes human antigen. The YTHDF3 antibody has been validated for the following applications: ELISA, WB analysis.