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- References [24]
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- Product number
- 25537-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- YTHDF3-specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated YTHDF3-specific antibody (Cat. #25537-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Differential roles of YTHDF1 and YTHDF3 in embryonic stem cell-derived cardiomyocyte differentiation.
METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression.
Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
MYC promotes cancer progression by modulating m6 A modifications to suppress target gene translation.
METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding.
Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.
GR-mediated transcriptional regulation of m6A metabolic genes contributes to diet-induced fatty liver in hens.
m6A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation.
KDM5B promotes self-renewal of hepatocellular carcinoma cells through the microRNA-448-mediated YTHDF3/ITGA6 axis.
Enterovirus 2Apro Cleavage of the YTHDF m6A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.
m6A-binding YTHDF proteins promote stress granule formation.
Modulation of circRNA Metabolism by m6A Modification.
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation.
HIV protease cleaves the antiviral m6A reader protein YTHDF3 in the viral particle.
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1.
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
Dynamic m6A mRNA methylation reveals the role of METTL3-m6A-CDCP1 signaling axis in chemical carcinogenesis.
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.
m6A facilitates hippocampus-dependent learning and memory through YTHDF1.
RNA m6 A modification enzymes shape innate responses to DNA by regulating interferon β.
Wang S, Zhang J, Wu X, Lin X, Liu XM, Zhou J
RNA biology 2021 Sep;18(9):1354-1363
RNA biology 2021 Sep;18(9):1354-1363
METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.
Zhao F, Xu Y, Gao S, Qin L, Austria Q, Siedlak SL, Pajdzik K, Dai Q, He C, Wang W, O'Donnell JM, Tang B, Zhu X
Molecular neurodegeneration 2021 Sep 30;16(1):70
Molecular neurodegeneration 2021 Sep 30;16(1):70
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2021 Nov 26;:e24019
Journal of clinical laboratory analysis 2021 Nov 26;:e24019
Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression.
He RZ, Jiang J, Hu X, Lei M, Li J, Luo W, Duan L, Hu Z, Mo YY, Luo DX, Peng WX
Cancer cell international 2021 Nov 22;21(1):616
Cancer cell international 2021 Nov 22;21(1):616
Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
Peng F, Xu J, Cui B, Liang Q, Zeng S, He B, Zou H, Li M, Zhao H, Meng Y, Chen J, Liu B, Lv S, Chu P, An F, Wang Z, Huang J, Zhan Y, Liao Y, Lu J, Xu L, Zhang J, Sun Z, Li Z, Wang F, Lam EW, Liu Q
Cell research 2021 Mar;31(3):345-361
Cell research 2021 Mar;31(3):345-361
MYC promotes cancer progression by modulating m6 A modifications to suppress target gene translation.
Wu G, Suo C, Yang Y, Shen S, Sun L, Li ST, Zhou Y, Yang D, Wang Y, Cai Y, Wang N, Zhang H, Yang YG, Cao J, Gao P
EMBO reports 2021 Mar 3;22(3):e51519
EMBO reports 2021 Mar 3;22(3):e51519
METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding.
Wang W, Shao F, Yang X, Wang J, Zhu R, Yang Y, Zhao G, Guo D, Sun Y, Wang J, Xue Q, Gao S, Gao Y, He J, Lu Z
Nature communications 2021 Jun 21;12(1):3803
Nature communications 2021 Jun 21;12(1):3803
Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.
Xia Z, Tang M, Ma J, Zhang H, Gimple RC, Prager BC, Tang H, Sun C, Liu F, Lin P, Mei Y, Du R, Rich JN, Xie Q
Nucleic acids research 2021 Jul 21;49(13):7361-7374
Nucleic acids research 2021 Jul 21;49(13):7361-7374
GR-mediated transcriptional regulation of m6A metabolic genes contributes to diet-induced fatty liver in hens.
Feng Y, Li Y, Jiang W, Hu Y, Jia Y, Zhao R
Journal of animal science and biotechnology 2021 Dec 7;12(1):117
Journal of animal science and biotechnology 2021 Dec 7;12(1):117
m6A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation.
Zhang JX, Huang PJ, Wang DP, Yang WY, Lu J, Zhu Y, Meng XX, Wu X, Lin QH, Lv H, Xie H, Wang RL
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Dec 1;29(12):3436-3448
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Dec 1;29(12):3436-3448
KDM5B promotes self-renewal of hepatocellular carcinoma cells through the microRNA-448-mediated YTHDF3/ITGA6 axis.
Guo JC, Liu Z, Yang YJ, Guo M, Zhang JQ, Zheng JF
Journal of cellular and molecular medicine 2021 Apr 7;
Journal of cellular and molecular medicine 2021 Apr 7;
Enterovirus 2Apro Cleavage of the YTHDF m6A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.
Kastan JP, Tremblay MW, Brown MC, Trimarco JD, Dobrikova EY, Dobrikov MI, Gromeier M
mBio 2021 Apr 13;12(2)
mBio 2021 Apr 13;12(2)
m6A-binding YTHDF proteins promote stress granule formation.
Fu Y, Zhuang X
Nature chemical biology 2020 Sep;16(9):955-963
Nature chemical biology 2020 Sep;16(9):955-963
Modulation of circRNA Metabolism by m6A Modification.
Di Timoteo G, Dattilo D, Centrón-Broco A, Colantoni A, Guarnacci M, Rossi F, Incarnato D, Oliviero S, Fatica A, Morlando M, Bozzoni I
Cell reports 2020 May 12;31(6):107641
Cell reports 2020 May 12;31(6):107641
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
Sheng H, Li Z, Su S, Sun W, Zhang X, Li L, Li J, Liu S, Lu B, Zhang S, Shan C
Carcinogenesis 2020 Jul 10;41(5):541-550
Carcinogenesis 2020 Jul 10;41(5):541-550
Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation.
Brocard M, Iadevaia V, Klein P, Hall B, Lewis G, Lu J, Burke J, Willcocks MM, Parker R, Goodfellow IG, Ruggieri A, Locker N
PLoS pathogens 2020 Jan;16(1):e1008250
PLoS pathogens 2020 Jan;16(1):e1008250
HIV protease cleaves the antiviral m6A reader protein YTHDF3 in the viral particle.
Jurczyszak D, Zhang W, Terry SN, Kehrer T, Bermúdez González MC, McGregor E, Mulder LCF, Eckwahl MJ, Pan T, Simon V
PLoS pathogens 2020 Feb;16(2):e1008305
PLoS pathogens 2020 Feb;16(2):e1008305
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
Zhang Y, Liu X, Liu L, Li J, Hu Q, Sun R
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1.
Yarmishyn AA, Yang YP, Lu KH, Chen YC, Chien Y, Chou SJ, Tsai PH, Ma HI, Chien CS, Chen MT, Wang ML
Cancer cell international 2020 Dec 14;20(1):597
Cancer cell international 2020 Dec 14;20(1):597
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
Wang Y, Gao M, Zhu F, Li X, Yang Y, Yan Q, Jia L, Xie L, Chen Z
Nature communications 2020 Apr 3;11(1):1648
Nature communications 2020 Apr 3;11(1):1648
Dynamic m6A mRNA methylation reveals the role of METTL3-m6A-CDCP1 signaling axis in chemical carcinogenesis.
Yang F, Jin H, Que B, Chao Y, Zhang H, Ying X, Zhou Z, Yuan Z, Su J, Wu B, Zhang W, Qi D, Chen D, Min W, Lin S, Ji W
Oncogene 2019 Jun;38(24):4755-4772
Oncogene 2019 Jun;38(24):4755-4772
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.
Hao H, Hao S, Chen H, Chen Z, Zhang Y, Wang J, Wang H, Zhang B, Qiu J, Deng F, Guan W
Nucleic acids research 2019 Jan 10;47(1):362-374
Nucleic acids research 2019 Jan 10;47(1):362-374
m6A facilitates hippocampus-dependent learning and memory through YTHDF1.
Shi H, Zhang X, Weng YL, Lu Z, Liu Y, Lu Z, Li J, Hao P, Zhang Y, Zhang F, Wu Y, Delgado JY, Su Y, Patel MJ, Cao X, Shen B, Huang X, Ming GL, Zhuang X, Song H, He C, Zhou T
Nature 2018 Nov;563(7730):249-253
Nature 2018 Nov;563(7730):249-253
RNA m6 A modification enzymes shape innate responses to DNA by regulating interferon β.
Rubio RM, Depledge DP, Bianco C, Thompson L, Mohr I
Genes & development 2018 Dec 1;32(23-24):1472-1484
Genes & development 2018 Dec 1;32(23-24):1472-1484
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The YTHDF3 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human YTHDF3. This antibody recognizes human antigen. The YTHDF3 antibody has been validated for the following applications: ELISA, WB analysis.
