CABT-B1894

antibody from Creative Diagnostics

Targeting: SPPL2A IMP3, PSL2

Western blot (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-B1894

Provider

Creative Diagnostics

Product name

Anti-SPPL2a (Cytoplasmic domain) polyclonal antibody

Antibody type

Polyclonal

Description

Signal-peptide-peptidase-like 2A (SPPL2a), a member of aspartic protease family, is an ubiquitously expressed intramembrane protease that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. It has been implicated in the proteolysis of TNF-a, Fas Ligand, and Bri2. SPPL2a exhibits about 7-0% homology with SPPL2b, however, the later is expressed primarily in adrenal cortex and mammary gland. Over-expressed SPPL2a is observed in late endosomal compartments where it co-localizes with Rab7. Its lysosomal/late endosomal sorting is dependent on a single tyrosine-based motif (Tyr498) in its cytoplasmic tail.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 _g

Concentration

Please refer to lot specific datasheet.

Storage

Stable for 1 year at 2-8°C from date of receipt.