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Protein structure
BCL2L10
BCL2 like 10BCL-B, Boo, Diva
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Invitrogen Antibodies |  MA5-31647 |
Monoclonal |
WB
EL
ICC
IHC
FC
|
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| antibodies-online | ABIN5683076 |
Monoclonal |
WB
EL
ICC
IHC
FC
|
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| Novus Biologicals | NBP2-61703 |
Monoclonal |
WB
EL
ICC
IHC
FC
|
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| OriGene | TA308442 |
1 references | Polyclonal |
WB
ICC
IHC
|
|
| Proteintech Group | 18114-1-AP |
1 references | Polyclonal |
WB
EL
IHC
|
|
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