SULF1

This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Description

Sulfatase 1

Tissue specificity

Tissue enhanced (choroid plexus)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8 (69466624 - 69660915)

Ensembl ID

ENSG00000137573  (ver. 103.38)

Orthologs

Mouse Sulf1: ENSMUSG00000016918

UniProt

Q8IWU6

neXtProt

NX_Q8IWU6

Human splice variants
Mouse splice variants

Protein structure