BS8081

antibody from Bioworld Technology, Inc
Targeting: MTDH 3D3, AEG-1, LYRIC
Provider product page for BS8081
Western blot
Immunohistochemistry

Antibody data

Product number
BS8081 - Provider product page
Provider
Bioworld Technology, Inc
Product name
MTDH polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human MTDH.
Description
MTDH (metastasis adhesion protein), also known as astrocyte elevated gene-1 protein (AEG1) or lysine-rich CEACAM1 co-isolated protein (LYRIC), is a 582 amino acid single-pass membrane protein. Overexpressed in various cancers, MTDH activates the transcription factor NF°ÙB and promotes anchorage-independent growth of immortalized astrocytes and melanocytes, which are key components of tumor growth. MTDH is also thought to enhance the seeding of tumor cells to the target organ endothelium. Localized mainly to the endoplasmic reticulum membrane, MTDH also translocates from the cytoplasm to the nucleus when induced by TNFÏ«. MTDH also localizes to tight junctions (TJ) during the maturation of TJ complexes in epithelial cells. MTDH is found at highest levels in heart, skeletal muscle, tongue and small intestine.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
MTDH protein structure - BS8081 shown in red.