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- References [17]
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- Product number
- 21698-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21698-1-AP, RRID:AB_10858626
- Product name
- NEDD4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NEDD4 antibody (Cat. #21698-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, monkey and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Samotolisib Attenuates Acute Liver Injury Through Inhibiting Caspase-11-Mediated Pyroptosis Via Regulating E3 Ubiquitin Ligase Nedd4.
Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis.
Tumor-derived exosomal miR-19b-3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway.
Human cytomegalovirus UL42 protein inhibits the degradation of glycoprotein B through inhibition of Nedd4 family ubiquitin E3 ligases.
HECT E3 Ubiquitin Ligase Nedd4 Is Required for Antifungal Innate Immunity.
JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling.
Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer.
Multivesicular body sorting and the exosomal pathway are required for the release of rat hepatitis E virus from infected cells.
Promotion of liver growth by CAR is accompanied by Akt pathway activation and FoxM1-Nedd4-mediated repression of PTEN.
NEDD4 protects vascular endothelial cells against Angiotensin II-induced cell death via enhancement of XPO1-mediated nuclear export.
YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein.
N-myc downstream-regulated gene 1 inhibits the proliferation of colorectal cancer through emulative antagonizing NEDD4-mediated ubiquitylation of p21.
Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies.
Inhibition of ubiquitin proteasome function prevents monocrotaline-induced pulmonary arterial remodeling.
Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer.
Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis.
O-GlcNAc regulates NEDD4-1 stability via caspase-mediated pathway.
Zhao YY, Wu DM, He M, Zhang F, Zhang T, Liu T, Li J, Li L, Xu Y
Frontiers in pharmacology 2021;12:726198
Frontiers in pharmacology 2021;12:726198
Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis.
Wang H, Wang J, Zhang S, Jia J, Liu X, Zhang J, Wang P, Song X, Che L, Liu K, Ribback S, Cigliano A, Evert M, Wu H, Calvisi DF, Zeng Y, Chen X
Cellular and molecular gastroenterology and hepatology 2021;11(4):1095-1117
Cellular and molecular gastroenterology and hepatology 2021;11(4):1095-1117
Tumor-derived exosomal miR-19b-3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway.
Chen J, Zhang K, Zhi Y, Wu Y, Chen B, Bai J, Wang X
Clinical and translational medicine 2021 Sep;11(9):e478
Clinical and translational medicine 2021 Sep;11(9):e478
Human cytomegalovirus UL42 protein inhibits the degradation of glycoprotein B through inhibition of Nedd4 family ubiquitin E3 ligases.
Koshizuka T, Kondo H, Kato H, Takahashi K
Microbiology and immunology 2021 Nov;65(11):472-480
Microbiology and immunology 2021 Nov;65(11):472-480
HECT E3 Ubiquitin Ligase Nedd4 Is Required for Antifungal Innate Immunity.
Nuro-Gyina PK, Tang N, Guo H, Yan C, Zeng Q, Waldschmidt TJ, Zhang J
Journal of immunology (Baltimore, Md. : 1950) 2021 Aug 1;207(3):868-877
Journal of immunology (Baltimore, Md. : 1950) 2021 Aug 1;207(3):868-877
JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling.
Ren Y, Chen D, Zhai Z, Chen J, Li A, Liang Y, Zhou J
Cell death discovery 2021 Apr 19;7(1):85
Cell death discovery 2021 Apr 19;7(1):85
Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer.
Zhang P, Li C, Li H, Yuan L, Dai H, Peng Z, Deng Z, Chang Z, Cui CP, Zhang L
Cell death and differentiation 2020 Nov;27(11):3177-3195
Cell death and differentiation 2020 Nov;27(11):3177-3195
Multivesicular body sorting and the exosomal pathway are required for the release of rat hepatitis E virus from infected cells.
Primadharsini PP, Nagashima S, Takahashi M, Kobayashi T, Nishiyama T, Nishizawa T, Yasuda J, Mulyanto, Okamoto H
Virus research 2020 Mar;278:197868
Virus research 2020 Mar;278:197868
Promotion of liver growth by CAR is accompanied by Akt pathway activation and FoxM1-Nedd4-mediated repression of PTEN.
Yarushkin AA, Mazin ME, Pustylnyak YA, Prokopyeva EA, Pustylnyak VO
Archives of biochemistry and biophysics 2019 Sep 15;672:108065
Archives of biochemistry and biophysics 2019 Sep 15;672:108065
NEDD4 protects vascular endothelial cells against Angiotensin II-induced cell death via enhancement of XPO1-mediated nuclear export.
Xu J, Sheng Z, Li F, Wang S, Yuan Y, Wang M, Yu Z
Experimental cell research 2019 Oct 1;383(1):111505
Experimental cell research 2019 Oct 1;383(1):111505
YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein.
Shen X, Zhong J, Yu P, Zhao Q, Huang T
Biochemical and biophysical research communications 2019 Feb 5;509(2):448-454
Biochemical and biophysical research communications 2019 Feb 5;509(2):448-454
N-myc downstream-regulated gene 1 inhibits the proliferation of colorectal cancer through emulative antagonizing NEDD4-mediated ubiquitylation of p21.
Zhang S, Yu C, Yang X, Hong H, Lu J, Hu W, Hao X, Li S, Aikemu B, Yang G, He Z, Zhang L, Xue P, Cai Z, Ma J, Zang L, Feng B, Yuan F, Sun J, Zheng M
Journal of experimental & clinical cancer research : CR 2019 Dec 12;38(1):490
Journal of experimental & clinical cancer research : CR 2019 Dec 12;38(1):490
Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies.
Juenemann K, Jansen AHP, van Riel L, Merkx R, Mulder MPC, An H, Statsyuk A, Kirstein J, Ovaa H, Reits EA
Scientific reports 2018 Jan 23;8(1):1405
Scientific reports 2018 Jan 23;8(1):1405
Inhibition of ubiquitin proteasome function prevents monocrotaline-induced pulmonary arterial remodeling.
Zhu Y, Wu Y, Shi W, Wang J, Yan X, Wang Q, Liu Y, Yang L, Gao L, Li M
Life sciences 2017 Mar 15;173:36-42
Life sciences 2017 Mar 15;173:36-42
Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer.
Sun H, Ma H, Wang J, Xia L, Zhu G, Wang Z, Sun J, Chen Z
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317709639
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317709639
Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis.
Li S, Mi L, Yu L, Yu Q, Liu T, Wang GX, Zhao XY, Wu J, Lin JD
Proceedings of the National Academy of Sciences of the United States of America 2017 Aug 22;114(34):E7111-E7120
Proceedings of the National Academy of Sciences of the United States of America 2017 Aug 22;114(34):E7111-E7120
O-GlcNAc regulates NEDD4-1 stability via caspase-mediated pathway.
Jiang K, Bai B, Ta Y, Zhang T, Xiao Z, Wang PG, Zhang L
Biochemical and biophysical research communications 2016 Mar 18;471(4):539-44
Biochemical and biophysical research communications 2016 Mar 18;471(4):539-44
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- C6 cells were subjected to SDS PAGE followed by western blot with 21698-1-AP(NEDD4 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NEDD4 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human NEDD4. This antibody recognizes human,mouse,rat, monkey antigen. The NEDD4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
