BS8413

antibody from Bioworld Technology, Inc

Targeting: ST8SIA4 PST, PST1, SIAT8D

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS8413

Provider

Bioworld Technology, Inc

Product name

ST8SIA4 polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human ST8SIA4.

Description

ST8Sia IV (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase IV), also known as PST, PST1 or SIAT8D, is a 359 amino acid single-pass type II membrane protein that localizes to the membrane of the Golgi apparatus. Highly expressed in heart, thymus and spleen, as well as fetal lung, brain and kidney, ST8Sia IV functions to catalyze the polycondensation of alpha-2,8-linked sialic acid, an event that is required for the synthesis of polysialic acid (PSA). PSA is an important regulator of neuronal plasticity and is present in embryonic brain tissue, where it interacts with NCAM (neural cell adhesion molecule) and plays a crucial role in fetal brain development. Defects in the gene encoding ST8Sia IV are associated with idiopathic pancreatitis, schizophrenia and tumor formation/metastasis. ST8Sia IV exists as multiple isoforms produced by alternative splicing events.

Reactivity

Human, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.